Acidosis and cancer: from mechanism to neutralization

Hypoxia and acidosis: immune suppressors and therapeutic targets

(2018) Sultan Damgaci et al.   IMMUNOLOGY

Intratumoral Spatial Heterogeneity at Perfusion MR Imaging Predicts Recurrence-free Survival in Locally Advanced Breast Cancer Treated with Neoadjuvant Chemotherapy

(2018) Jia Wu et al.   RADIOLOGY

Systems analysis of intracellular pH vulnerabilities for cancer therapy

(2018) Erez Persi et al.   Nature Communications

Perinodular and Intranodular Radiomic Features on Lung CT Images Distinguish Adenocarcinomas from Granulomas

(2018) Niha Beig et al.   RADIOLOGY

A unifying mathematical model of lipid droplet metabolism reveals key molecular players in the development of hepatic steatosis

(2017) Christin Wallstab et al.   FEBS Journal

Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation

(2017) Sofia Avnet et al.   INTERNATIONAL JOURNAL OF CANCER

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

(2017) T H Dovmark et al.   ONCOGENE

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

(2017) L. Tirinato et al.   Stem Cells International

Tris-base buffer: a promising new inhibitor for cancer progression and metastasis

(2017) Arig Ibrahim-Hashim et al.   Cancer Medicine

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Pathophysiology of lipid droplet proteins in liver diseases

(2016) Rotonya M. Carr et al.   EXPERIMENTAL CELL RESEARCH

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Acidic tumor microenvironment in human melanoma

(2016) Ines Böhme et al.   Pigment Cell & Melanoma Research

Radiomics: Images Are More than Pictures, They Are Data

(2016) Robert J. Gillies et al.   RADIOLOGY

Association of multiparametric MRI quantitative imaging features with prostate cancer gene expression in MRI-targeted prostate biopsies

(2016) Radka Stoyanova et al.   Oncotarget

Production and Characterization of a Camelid Single Domain Antibody–Urease Enzyme Conjugate for the Treatment of Cancer

(2015) Baomin Tian et al.   BIOCONJUGATE CHEMISTRY

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane

(2015) Mehdi Damaghi et al.   Nature Communications

Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma

(2015) Olya Grove et al.   PLoS One

Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins

(2015) Jennifer M Rothberg et al.   NEOPLASIA

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

(2014) Paola Pellegrini et al.   Autophagy

Vascular measurements correlate with estrogen receptor status

(2014) Mark C Lloyd et al.   BMC CANCER

Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome

(2014) J. P. B. O'Connor et al.   CLINICAL CANCER RESEARCH

Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

(2014) Hugo J. W. L. Aerts et al.   Nature Communications

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Balancing the fat: lipid droplets and human disease

(2013) Natalie Krahmer et al.   EMBO Molecular Medicine

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Quantitative Imaging in Cancer Evolution and Ecology

(2013) Robert A. Gatenby et al.   RADIOLOGY

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

Autophagy on acid

(2012) Jonathan W. Wojtkowiak et al.   Autophagy

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

(2012) Jonathan W. Wojtkowiak et al.   CANCER RESEARCH

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

(2012) Maria Lucia Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Buffers Inhibit Carcinogenesis in TRAMP Mice

(2012) Arig Ibrahim-Hashim et al.   JOURNAL OF UROLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduction of metastasis using a non-volatile buffer

(2011) Arig Ibrahim Hashim et al.   CLINICAL & EXPERIMENTAL METASTASIS

Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification

(2011) Caryl J. Antalis et al.   CLINICAL & EXPERIMENTAL METASTASIS

Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes

(2011) N. K. Tafreshi et al.   CLINICAL CANCER RESEARCH

Acid-Sensing Ion Channels Contribute to the Effect of Acidosis on the Function of Dendritic Cells

(2011) J. Tong et al.   JOURNAL OF IMMUNOLOGY

Imaging pH and metastasis

(2011) Arig Ibrahim Hashim et al.   NMR IN BIOMEDICINE

MR-visible lipids and the tumor microenvironment

(2011) E. James Delikatny et al.   NMR IN BIOMEDICINE

Tumor pH and Its Measurement

(2010) X. Zhang et al.   JOURNAL OF NUCLEAR MEDICINE

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH