Article
Biology
Lilya Andrianova, Steliana Yanakieva, Gabriella Margetts-Smith, Shivali Kohli, Erica S. Brady, John P. Aggleton, Michael T. Craig
Summary: The connectivity and interplay between the prefrontal cortex and hippocampus are important for cognitive processes, but the existence of a direct glutamatergic projection from the anterior cingulate cortex to the hippocampus has been questioned. In this study, multiple methods were used to validate a recent finding of this projection, but no evidence of such a projection was found.
Article
Psychiatry
Dorien Vandael, Keimpe Wierda, Katlijn Vints, Pieter Baatsen, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia Gounko
Summary: CRF plays a central role in regulating physiological responses to stress by rapidly enhancing synaptic communication in the hippocampus. This process involves changes in both functional and structural aspects of synapses, leading to improvements in synaptic strength and plasticity, which may contribute to enhanced memory consolidation under acute stress.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Isabel Baron-Mendoza, Emely Maqueda-Martinez, Monica Martinez-Marcial, Marisol De la Fuente-granada, Margarita Gomez-Chavarin, Aliesha Gonzalez-Arenas
Summary: This study evaluated dendritic spine differences in the hippocampus and prefrontal cortex of the ASD animal model C58/J, finding changes in spine number and morphology in a brain region-dependent manner. Additionally, genetic analysis suggested a likely association between genes involved in regulating structural plasticity and ASD, supporting a relationship between the C58/J strain genome, autistic-like behavior, and observed dendritic spine anomalies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Sonja Chu, Cendri Hutcherson, Rutsuko Ito, Andy C. H. Lee
Summary: The prefrontal cortex (PFC) and medial temporal lobe (MTL) contribute differently to resolving conflict information and uncertainty during approach-avoidance decisions. The PFC may adjust response caution and evidence strength towards each choice, involving the anterior cingulate cortex and dorsolateral prefrontal cortex, while the MTL contributes to evidence generation, particularly through the hippocampus. These findings suggest unique contributions of MTL and PFC regions in arbitrating approach-avoidance conflict.
Article
Behavioral Sciences
Marisela Hernandez-Gonzalez, Francisco Javier Barrera-Cobos, Enrique Hernandez-Arteaga, Ignacio Gonzalez-Burgos, Mario Flores-Soto, Miguel Angel Guevara, Pedro Manuel Cortes
Summary: Sexual experience improves copulatory performance in male rats by promoting changes in the density of dendritic spines in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAcc). Specifically, sexually experienced rats exhibited higher total dendritic density and increased numerical density of certain types of dendritic spines in the mPFC and NAcc. Furthermore, there was a shift in the proportional density of different types of dendritic spines towards a higher proportion of mushroom spines. These findings suggest that sexual experience can lead to consolidation of synaptic information in the brain regions involved in sexual behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biology
Geoffrey W. Diehl, A. David Redish
Summary: Decision-making requires different aspects of information and involves multiple cognitive processes. The rodent medial prefrontal cortex (mPFC) is believed to play a central role in these abilities. Previous studies on mPFC function have yielded controversial results, but this study with rats performing an economic decision task revealed four distinct functional domains within mPFC, closely related to anatomical subregions. Dorsal mPFC regions were more involved in processing active decisions, while ventral regions were more engaged in motivational factors.
Article
Chemistry, Multidisciplinary
Shu-jian Chen, Cong-cong Gao, Qun-yu Lv, Meng-qi Zhao, Xiao-ying Qin, Hong Liao
Summary: Knocking down sortilin in the prefrontal cortex and hippocampus can alleviate depressive-like behaviors induced by chronic unpredictable mild stress, mainly by decreasing ASM trafficking of ceramide.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Liping Xu, Yue Liu, Jingyi Long, Xiulan He, Fanbing Xie, Qiao Yin, Michael Chen, Dahong Long, Yuncai Chen
Summary: Adverse experiences in early life can lead to deficits in cognitive functions in later life by shaping neuronal structures and synaptic function in multiple brain regions. This study focuses on the impact of early-life adversity (ELA) on the dendritic spines of pyramidal cells in the prelimbic cortex (PrL), revealing enduring detrimental effects of ELA on the PrL dendritic spines. ELA mice show a selective loss of spines in specific dendritic segments of PrL pyramidal cells, which contributes to the poor spatial working memory observed in these mice.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Marcos Domic-Siede, Martin Irani, Joaquin Valdes, Marcela Perrone-Bertolotti, Tomas Ossandon
Summary: The study reveals the importance of cognitive planning in human goal-directed behavior, with different brain regions playing specific roles in the planning process. Activity in the prefrontal cortex is associated with increased time needed for plan elaboration, while activity in the frontopolar cortex is negatively correlated with execution time, indicating its role in efficiency and accuracy in plan execution. Theta activity in different brain regions reflects high cognitive demand and the successful generation of self-made plans.
Article
Neurosciences
Billy Kim, Dowon Kim, Anton Schulmann, Yash Patel, Carolina Caban-Rivera, Paul Kim, Ananya Jambhale, Kory R. Johnson, Ningping Feng, Qing Xu, Sun Jung Kang, Ajeet Mandal, Michael Kelly, Nirmala Akula, Francis J. McMahon, Barbara Lipska, Stefano Marenco, Pavan K. Auluck
Summary: Regional cellular heterogeneity in human neocortex is still unclear. This study uses single-nucleus RNA-sequencing to examine cell-specific transcriptional features in DLPFC and sgACC, finding more inhibitory cells in sgACC and considerable variability in excitatory neuron subclusters across brain regions. In addition, genetic signals of psychiatric disorders are mainly enriched in neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Nestor I. Martinez-Torres, Nallely Vazquez-Hernandez, Fabiola L. Martin-Amaya-Barajas, Mario Flores-Soto, Ignacio Gonzalez-Burgos
Summary: The study found that lesions induced by Ibotenic acid (IA) affect social behavior and working memory in rats, leading to decreased dendritic spine density and reduced protein content. Plastic changes in the proportion of dendritic spine types suggest the activation of compensatory processes in response to the adverse effects of the lesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Yuefeng Huang, Anusha Mohan, S. Lauren McLeod, Alison M. Luckey, John Hart Jr, Sven Vanneste
Summary: The study demonstrates that modulating activity in the aDMN and pDMN causally affect memory retrieval performance. Anodal stimulation of the pDMN and cathodal stimulation of the aDMN equally improve the percentage of word-associations recalled 7 days after learning, suggesting a possible functional dissociation between the aDMN and pDMN in episodic memory retrieval.
Article
Behavioral Sciences
Ekaterina Pershina, Tatyana P. Kulagina, Tatyana A. Savina, Alexander Aripovsky, Sergey G. Levin, Vladimir Arkhipov
Summary: The study found significant changes in fatty acid levels in the prefrontal cortex and hippocampus of rats trained for a task with food reinforcement. These changes returned to control levels 72 hours after training. The reversible increase in fatty acid levels may support and protect cellular processes involved in memory acquisition.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yuqing Lu, Xiangzan Wei, Wei Li, Xujun Wu, Chao Chen, Ge Li, Zhongqiang Huang, Yunfeng Li, Yu Zhang, Wen-Biao Gan
Summary: In this study, we developed a method combining a thin-wall quartz capillary with a GRIN lens to perform large-volume imaging of neurons located 2mm below the surface of rabbit and monkey brains. By rotating and changing the depth of the imaging probe, we greatly expanded the field of view. We found differential activity of layer 5/6 neurons in the rabbit motor cortex between quiet wakefulness and slow wave sleep.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Zhongzheng Fu, Danielle Beam, Jeffrey M. Chung, Chrystal M. Reed, Adam N. Mamelak, Ralph Adolphs, Ueli Rutishauser
Summary: Monitoring one's own performance is crucial for flexibly achieving desired goals. In this study, single neurons in the human medial frontal cortex were recorded while subjects performed two tasks involving cognitive conflict. The findings suggest that neuronal representations of evaluative signals can be both abstract and task-specific, providing insights into the neuronal mechanism for estimating control demand.
Editorial Material
Medicine, General & Internal
Anne-Laurence Boutillier, Laura Tzeplaeff, Luc Dupuis
Article
Cell Biology
Thomas H. Hutson, Claudia Kathe, Ilaria Palmisano, Kay Bartholdi, Arnau Hervera, Francesco De Virgiliis, Eilidh Mclachlan, Luming Zhou, Guiping Kong, Quentin Barraud, Matt C. Danzi, Alejandro Medrano-Fernandez, Jose P. Lopez-Atalaya, Anne L. Boutillier, Sarmistha H. Sinha, Akash K. Singh, Piyush Chaturbedy, Lawrence D. F. Moon, Tapas K. Kundu, John L. Bixby, Vance P. Lemmon, Angel Barco, Gregoire Courtine, Simone Di Giovanni
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Neurosciences
Gina Picchiarelli, Maria Demestre, Amila Zuko, Marije Been, Julia Higelin, Stephane Dieterle, Marc-Antoine Goy, Moushami Mallik, Chantal Sellier, Jelena Scekic-Zahirovic, Li Zhang, Angela Rosenbohm, Celine Sijlmans, Amr Aly, Sina Mersmann, Inmaculada Sanjuan-Ruiz, Annemarie Huebers, Nadia Messaddeq, Marina Wagner, Nick van Bakel, Anne-Laurence Boutillier, Albert Ludolph, Clotilde Lagier-Tourenne, Tobias M. Boeckers, Luc Dupuis, Erik Storkebaum
NATURE NEUROSCIENCE
(2019)
Article
Clinical Neurology
Estelle Schueller, Isabel Paiva, Frederic Blanc, Xiao-Lan Wang, Jean-Christophe Cassel, Anne-Laurence Boutillier, Olivier Bousiges
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Behavioral Sciences
Julien Gasser, Anne Pereira de Vasconcelos, Brigitte Cosquer, Anne-Laurence Boutillier, Jean-Christophe Cassel
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Review
Neurosciences
Rafael Alcala-Vida, Ali Awada, Anne-Laurence Boutillier, Karine Merienne
Summary: Neurodegenerative diseases are characterized by selective loss of neuronal regions and glial cell changes. Alterations in transcriptional enhancers play a critical role in HD and AD, highlighting the challenging task of deciphering the epigenetic code of these diseases.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Rafael Alcala-Vida, Jonathan Seguin, Caroline Lotz, Anne M. Molitor, Ibai Irastorza-Azcarate, Ali Awada, Nezih Karasu, Aurelie Bombardier, Brigitte Cosquer, Jose Luis Gomez Skarmeta, Jean-Christophe Cassel, Anne-Laurence Boutillier, Thomas Sexton, Karine Merienne
Summary: This study utilizes a Huntington's mouse model to analyze the chromatin landscape in the striatum, revealing that the Huntington's mutation accelerates age-related epigenetic and transcriptional changes, and affects 3D chromatin organization locally.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Xiao-Lan Wang, Samantha E. C. Wolff, Nikita Korpel, Irina Milanova, Cristina Sandu, Patrick C. N. Rensen, Sander Kooijman, Jean-Christophe Cassel, Andries Kalsbeek, Anne-Laurence Boutillier, Chun-Xia Yi
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Nour El Houda Mimouni, Isabel Paiva, Anne-Laure Barbotin, Fatima Ezzahra Timzoura, Damien Plassard, Stephanie Le Gras, Gaetan Ternier, Pascal Pigny, Sophie Catteau-Jonard, Virginie Simon, Vincent Prevot, Anne-Laurence Boutillier, Paolo Giacobini
Summary: The study revealed that DNA hypomethylation regulates key genes associated with PCOS, and treatment of PCOS mouse models with a methyl donor corrected their defects. Methylome markers may serve as a possible diagnostic landmark for the condition.
Article
Biochemistry & Molecular Biology
Xiao-Lan Wang, Sander Kooijman, Yuanqing Gao, Laura Tzeplaeff, Brigitte Cosquer, Irina Milanova, Samantha E. C. Wolff, Nikita Korpel, Marie-France Champy, Benoit Petit-Demouliere, Isabelle Goncalves Da Cruz, Tania Sorg-Guss, Patrick C. N. Rensen, Jean-Christophe Cassel, Andries Kalsbeek, Anne-Laurence Boutillier, Chun-Xia Yi
Summary: The study found that microglial Bmal1 plays a crucial role in metabolic stress and memory formation, as knocking it down led to enhanced phagocytosis activity and positive effects on neuronal activity in the brain, helping to combat obesity and improve memory test performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Jelena Scekic-Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa Kan, Salim Megat, Pierre De Rossi, Stephane Dieterle, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valerie Demais, Sonu Sahadevan, Katharina M. Hembach, Hans-Peter Muller, Gina Picchiarelli, Nibha Mishra, Stefano Antonucci, Sylvie Dirrig-Grosch, Jan Kassubek, Volker Rasche, Albert Ludolph, Anne-Laurence Boutillier, Francesco Roselli, Magdalini Polymenidou, Clotilde Lagier-Tourenne, Sabine Liebscher, Luc Dupuis
Summary: Mutations in the RNA binding protein FUS are associated with ALS. Here the authors show that in FUS knock-in mice there is a progressive increase in neuronal activity in the frontal cortex which is associated with altered synaptic gene expression.
NATURE COMMUNICATIONS
(2021)
Review
Clinical Neurology
Morgane Linard, Alix Ravier, Louisa Mougue, Iris Grgurina, Anne-Laurence Boutillier, Alexandra Foubert-Samier, Frederic Blanc, Catherine Helmer
Summary: This article reviews the ongoing research on the role of infectious agents in the onset of alpha-synucleinopathies, discussing factors such as the potential antimicrobial role of alpha-synuclein, entry points of pathogens, and the associations between infectious agents and different diseases.
MOVEMENT DISORDERS
(2022)
Article
Medicine, Research & Experimental
Isabel Paiva, Lucrezia Cellai, Celine Meriaux, Lauranne Poncelet, Ouada Nebie, Jean-Michel Saliou, Anne-Sophie Lacoste, Anthony Papegaey, Herve Drobecq, Stephanie Le Gras, Marion Schneider, Enas M. Malik, Christa E. Mueller, Emilie Faivre, Kevin Carvalho, Victoria Gomez-Murcia, Didier Vieau, Bryan Thiroux, Sabiha Eddarkaoui, Thibaud Lebouvier, Estelle Schueller, Laura Tzeplaeff, Iris Grgurina, Jonathan Seguin, Jonathan Stauber, Luisa V. Lopes, Luc Buee, Valerie Buee-Scherrer, Rodrigo A. Cunha, Rima Ait-Belkacem, Nicolas Sergeant, Jean-Sebastien Annicotte, Anne-Laurence Boutillier, David Blum
Summary: Chronic caffeine intake in mice has been found to exert various effects in the hippocampus, improving information encoding by fine-tuning metabolic genes and enhancing the salience of information processing.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Clinical Neurology
Laetitia Degiorgis, Meltem Karatas, Marion Sourty, Emilie Faivre, Julien Lamy, Vincent Noblet, Thomas Bienert, Marco Reisert, Dominik von Elverfeldt, Luc Buee, David Blum, Anne-Laurence Boutillier, Jean-Paul Armspach, Frederic Blanc, Laura-Adela Harsan
Article
Biology
Snehajyoti Chatterjee, Christopher C. Angelakos, Ethan Bahl, Joshua D. Hawk, Marie E. Gaine, Shane G. Poplawski, Anne Schneider-Anthony, Manish Yadav, Giulia S. Porcari, Jean-Christophe Cassel, K. Peter Giese, Jacob J. Michaelson, Lisa C. Lyons, Anne-Laurence Boutillier, Ted Abel