Article
Plant Sciences
Pan Su, Mengdi Wu, Xiaoting Yin, Mengyuan Li, Yucheng Li, Ming Bai, Baoying Wang, Erping Xu
Summary: This study aimed to investigate the antidepressant efficacy of Modified Xiaoyao San (MXYS) and its underlying mechanisms. The results showed that MXYS reversed depression-like behaviors and reduced neuronal damage in LPS-induced depressive mice. MXYS suppressed microglia M1 polarization and promoted autophagy in both the prefrontal cortex and LPS-stimulated N9 cells. These findings suggest that the antidepressant effect of MXYS may be mediated through the alleviation of neuroinflammation via suppression of microglia M1 polarization and enhancement of autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Medicinal
Yue Xu, Weiyin Chen, Zeran Chen, Mengyuan Huang, Fang Yang, Yang Zhang
Summary: This study explored the material basis and molecular mechanism of the traditional Chinese medicine formulation Xiaoyao San (XYS) in the treatment of ischemic stroke (IS) using network pharmacology, in vitro experiments, and molecular docking. XYS was found to target 175 proteins through 136 chemical components, with its main signaling pathways involving apoptosis and the phosphoinositide 3-kinase/protein kinase B (PI3K-Akt) pathway. In vitro experiments demonstrated that XYS could improve PC12-cell activity and inhibit apoptosis by regulating oxidative stress and apoptosis-related gene expression.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Junhua Pan, Shunlian Fu, Qian Zhou, Dajun Lin, Qiu Chen
Summary: This study comprehensively evaluated the efficacy and safety of modified Xiaoyao san (XYS) in combination with chemotherapy in treating breast cancer through systematic review and meta-analysis. The results showed that modified XYS combined with chemotherapy could lead to significant improvements compared to chemotherapy alone, including enhanced short-term efficacy, improved quality of life, reduced clinical symptoms, alleviated depression, increased leukocytes and platelets, reduced nausea and vomiting, mitigated cardiotoxicity, and prolonged survival time.
FRONTIERS IN ONCOLOGY
(2023)
Review
Plant Sciences
Zhiqiang Xie, Hongxiao Xie, Xi Peng, Jingwen Hu, Li Chen, Xiangyu Li, Hu Qi, Jiuseng Zeng, Nan Zeng
Summary: This study summarizes clinical and preclinical research on the antidepressant-like effects of Danzhi Xiaoyao San (DXS) and its active ingredients. DXS has been found to have therapeutic effects on depression patients with few side effects. It is believed that DXS and its active ingredients modulate monoamine neurotransmitter levels, inhibit hypothalamic-pituitary-adrenal (HPA) axis hyperfunction, reduce neuroinflammation, and increase neurotrophic factors, thereby exerting neuroprotective antidepressant-like effects.
Review
Medical Laboratory Technology
Masoomeh Dadkhah, Mohsen Jafarzadehgharehziaaddin, Soheila Molaei, Morteza Akbari, Negin Gholizadeh, Farzaneh Fathi
Summary: Depressive disorders, characterized by loss of interest in previously enjoyed activities and a depressed mood, are highly heterogeneous psychiatric diseases. Diagnosis and treatment of major depressive disorder (MDD) remain challenging due to significant clinical presentation heterogeneity and lack of applicable biomarkers. Identification of relevant biomarkers would enhance disease classification and personalized treatment strategies. In this review, we discuss the current state of these biomarkers and diagnostic techniques specifically targeting these analytes using state-of-the-art biosensor technology.
CLINICA CHIMICA ACTA
(2023)
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Tiffany C. Ho, Boris Gutman, Elena Pozzi, Hans J. Grabe, Norbert Hosten, Katharina Wittfeld, Henry Voelzke, Bernhard Baune, Udo Dannlowski, Katharina Foerster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J. Veltman, Knut Schnell, Ilya Veer, Henrik Walter, Ian H. Gotlib, Matthew D. Sacchet, Andre Aleman, Nynke A. Groenewold, Dan J. Stein, Meng Li, Martin Walter, Christopher R. K. Ching, Neda Jahanshad, Anjanibhargavi Ragothaman, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Philipp G. Saemann, Lianne Schmaal
Summary: This study investigated the differences in subcortical shape between patients with major depressive disorder (MDD) and healthy controls. The results showed that both adolescent-onset MDD and recurrent MDD patients had lower thickness and surface area in certain subcortical regions compared to healthy controls.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Joseigla Pinto de Oliveira, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: The study aimed to assess the role of childhood trauma in differentiating MDD and BD, as well as to describe the conversion rate from MDD to BD and its predictors. Findings indicated that predictors of conversion to BD included lower education, substance abuse, younger age of onset, and family history, while childhood trauma was not a significant risk factor for conversion.
PSYCHIATRY RESEARCH
(2021)
Review
Endocrinology & Metabolism
Wenxin Ma, Xiaowen Zhang, Ruotong Zhao, Yang Tang, Xiaoyun Zhu, Longkun Liu, Mingyuan Xu, Ge Wang, Peiyue Peng, Jianping Liu, Zhaolan Liu
Summary: This study evaluates the effectiveness and potential mechanism of traditional Chinese medicine Jiawei-Xiaoyao-San (JWXYS) as an adjunct or mono-therapy for antithyroid drugs (ATDs) in the treatment of hyperthyroidism. The findings suggest that JWXYS plus ATDs can lower FT3 and FT4 levels, increase TSH levels, reduce goiter score and thyrotrophin receptor antibody levels, and have fewer adverse events compared to ATDs alone.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: This study characterized the common and specific alterations in the dynamic local functional connectivity pattern in patients with bipolar depressive disorder (BDD) and major depressive disorder (MDD) using a newly developed method called dynamic regional phase synchrony (DRePS). The findings provided new insight into the neural mechanism of BDD and MDD patients and could potentially inform the diagnosis and treatment of these disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
J. Lumikukka Socada, John J. Soderholm, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: This study investigated the prevalence, severity, co-occurrence, and overlap of manic symptoms and borderline personality features in unipolar and bipolar major depressive episodes. The results showed that the presence of mixed and borderline features in MDEs is common, with differences in diagnosis-specific features among different subcohorts. The study highlighted the impact of hypomania on perceived BPD features and the correlation between manic symptoms and borderline features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Pharmacology & Pharmacy
Mimi Tang, Ting Liu, Pei Jiang, Ruili Dang
Summary: Neuroinflammation has been identified as an important mechanism of major depressive disorder, with the NLRP3 inflammasome playing a critical role in its pathogenesis. The autophagy signaling pathway is essential for regulating NLRP3 inflammasome activity, preventing excessive activation and release of inflammatory cytokines.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Mengmeng Wang, Weiliang Huang, Tingting Gao, Xiaoshan Zhao, Zhiping Lv
BRAIN RESEARCH BULLETIN
(2018)
Article
Chemistry, Medicinal
Yuan Liu, Yanmeng Bi, Chan Mo, Ting Zeng, Sha Huang, Lei Gao, Xuegang Sun, Zhiping Lv
JOURNAL OF NATURAL MEDICINES
(2019)
Article
Biochemistry & Molecular Biology
Qinrui Han, Lijun Xu, Weihao Lin, Xueqing Yao, Muhong Jiang, Rui Zhou, Xuegang Sun, Liang Zhao
Article
Biochemistry & Molecular Biology
Xiao-Lan Zhong, Xiao-Ming Liao, Fei Shen, Hai-Jian Yu, Wen-Sheng Yan, Yun-Fang Zhang, Jia-Jun Ye, Zhi-Ping Lv
Article
Clinical Neurology
Yanmeng Bi, Peng Huang, Zhaoyang Dong, Tingting Gao, Shaohui Huang, Lei Gao, Zhiping Lv
Article
Cell Biology
Xiaoting Chen, Hung Chan, Lin Zhang, Xiaodong Liu, Idy H. T. Ho, Xiang Zhang, Jeffery Ho, Wei Hu, Yuanyuan Tian, Shanglong Kou, Chee Sam Chan, Jun Yu, Sunny H. Wong, Tony Gin, Matthew T. V. Chan, Xuegang Sun, William K. K. Wu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Ting Zeng, Guanghui Deng, Weichao Zhong, Zhuowei Gao, Shuoyi Ma, Chan Mo, Yunjia Li, Sha Huang, Chuying Zhou, Yuqi Lai, Shuwen Xie, Zeping Xie, Yuyao Chen, Songqi He, Zhiping Lv, Lei Gao
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Sha Huang, Chuying Zhou, Ting Zeng, Yujia Li, Yuqi Lai, Chan Mo, Yuyao Chen, Shaohui Huang, Zhiping Lv, Lei Gao
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Chan Mo, Shuwen Xie, Weichao Zhong, Ting Zeng, Sha Huang, Yuqi Lai, Guanghui Deng, Chuying Zhou, Weixin Yan, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Neurosciences
Shanmei Zeng, Kai Liu, Jingyu Zhang, Chunhui Chen, Yihua Xu, Yulan Wu, Yanjia Deng, Xuegang Sun, Ge Wen, Linlin Jing
Article
Pharmacology & Pharmacy
Qinrui Han, Chun Zhang, Yongbin Zhang, Yuan Li, Liyi Wu, Xuegang Sun
Summary: The study demonstrated that bufarenogin inhibits the growth and metastasis of colorectal cancer by inducing intrinsic apoptosis, suggesting its potential therapeutic effect.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Biochemistry & Molecular Biology
Yu Dai, Bo Ai, Ying Liu, Laura E. Pascal, Zhou Wang, Rajiv Dhir, Xuegang Sun, Yu Jiang
Summary: The overexpression of Rab27B in prostatic epithelial cells in BPH was found to enhance cell proliferation by increasing signaling activities of the PI3K/AKT and ERK1/2 pathways. Additionally, Rab27B was observed to increase the cell surface presentation of growth factor receptors while also possessing an inhibitory activity against mTORC1. This small GTPase plays a pivotal role in autocrine and paracrine signaling and may contribute to the dysregulated stromal-epithelial interactions in BPH.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Plant Sciences
Min Zheng, Zhengyang Hu, Yibin Wang, Chunyan Wang, Chao Zhong, Weiwei Cui, Junxiong You, Baogui Gao, Xuegang Sun, Lei La
Summary: This study demonstrates that Zhen Wu Decoction (ZWD) reduces renal interstitial fibrosis in chronic kidney disease (CKD) by activating mitochondrial transcription factor A (TFAM) dependent on nuclear factor (erythmid-derived 2)-related factor 2 (NRF2), thereby improving renal function.