The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy
出版年份 2019 全文链接
标题
The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy
作者
关键词
-
出版物
Autophagy
Volume -, Issue -, Pages 1-16
出版商
Informa UK Limited
发表日期
2019-01-24
DOI
10.1080/15548627.2019.1569441
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
- (2017) Fiona M. Menzies et al. NEURON
- Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
- (2017) Jennifer Jung et al. eLife
- C9orf72 isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
- (2016) Shangxi Xiao et al. BRAIN RESEARCH
- Structure and function of the ULK1 complex in autophagy
- (2016) Mary G Lin et al. CURRENT OPINION IN CELL BIOLOGY
- Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
- (2016) Chantal Sellier et al. EMBO JOURNAL
- The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
- (2016) Christopher P Webster et al. EMBO JOURNAL
- Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation
- (2016) Francesca Nazio et al. JOURNAL OF CELL BIOLOGY
- Genetics of FTLD: overview and what else we can expect from genetic studies
- (2016) Cyril Pottier et al. JOURNAL OF NEUROCHEMISTRY
- Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions
- (2016) Tiffany W. Todd et al. JOURNAL OF NEUROCHEMISTRY
- Autophagy inhibition in endogenous and nutrient-deprived conditions reduces dorsal root ganglia neuron survival and neurite growth in vitro
- (2016) Joseph-Patrick Clarke et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis
- (2016) Joung Hyuck Joo et al. MOLECULAR CELL
- Decoding ALS: from genes to mechanism
- (2016) J. Paul Taylor et al. NATURE
- C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons
- (2016) Rajeeve Sivadasan et al. NATURE NEUROSCIENCE
- Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
- (2016) Jie Jiang et al. NEURON
- C9orf72 is required for proper macrophage and microglial function in mice
- (2016) J. G. ORourke et al. SCIENCE
- Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
- (2016) Aaron Burberry et al. Science Translational Medicine
- Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
- (2016) Janet Ugolino et al. PLoS Genetics
- A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
- (2016) M. Yang et al. Science Advances
- C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice
- (2016) Amanda Atanasio et al. Scientific Reports
- Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis
- (2015) Shangxi Xiao et al. ANNALS OF NEUROLOGY
- C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits
- (2015) Max Koppers et al. ANNALS OF NEUROLOGY
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
- (2015) Daniel F. Egan et al. MOLECULAR CELL
- Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
- (2015) Axel Freischmidt et al. NATURE NEUROSCIENCE
- Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
- (2015) E. T. Cirulli et al. SCIENCE
- ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP
- (2015) Shuying Sun et al. Nature Communications
- AMPK—Sensing Energy while Talking to Other Signaling Pathways
- (2014) D. Grahame Hardie Cell Metabolism
- C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
- (2014) Manal A. Farg et al. HUMAN MOLECULAR GENETICS
- Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
- (2014) Guomei Tang et al. NEURON
- The ULK1 complex
- (2013) Pui-Mun Wong et al. Autophagy
- The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
- (2013) Timothy P. Levine et al. BIOINFORMATICS
- Autophagy Negatively Regulates Early Axon Growth in Cortical Neurons
- (2013) B.-K. Ban et al. MOLECULAR AND CELLULAR BIOLOGY
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
- (2013) C. Lagier-Tourenne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy
- (2013) Han-Ming Shen et al. TRENDS IN BIOCHEMICAL SCIENCES
- Current insights into the C9orf72 repeat expansion diseases of the FTLD/ALS spectrum
- (2013) Marc Cruts et al. TRENDS IN NEUROSCIENCES
- Amyloid precursor protein (APP) regulates synaptic structure and function
- (2012) Sheue-Houy Tyan et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2011) Faisal Fecto ARCHIVES OF NEUROLOGY
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13
- (2011) Junli Liu et al. CELL
- DENN Domain Proteins: Regulators of Rab GTPases
- (2011) Andrea L. Marat et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study
- (2011) Ilse Gijselinck et al. LANCET NEUROLOGY
- Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
- (2011) S. Alers et al. MOLECULAR AND CELLULAR BIOLOGY
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- Unc-51/ATG1 Controls Axonal and Dendritic Development via Kinesin-Mediated Vesicle Transport in the Drosophila Brain
- (2011) Hiroaki Mochizuki et al. PLoS One
- Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
- (2010) Shin-ichiro Yoshimura et al. JOURNAL OF CELL BIOLOGY
- Mutations of optineurin in amyotrophic lateral sclerosis
- (2010) Hirofumi Maruyama et al. NATURE
- Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
- (2010) Janel O. Johnson et al. NEURON
- ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
- (2010) S.-C. Ling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atg101, a novel mammalian autophagy protein interacting with Atg13
- (2009) Nao Hosokawa et al. Autophagy
- UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly
- (2008) H. Toda et al. GENES & DEVELOPMENT
- Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes
- (2008) Laura Trinkle-Mulcahy et al. JOURNAL OF CELL BIOLOGY
- The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice
- (2008) Yu-shin Sou et al. MOLECULAR BIOLOGY OF THE CELL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now