Article
Geriatrics & Gerontology
Carina O. Walowski, Catrin Herpich, Janna Enderle, Wiebke Braun, Marcus Both, Mario Hasler, Manfred J. Mueller, Kristina Norman, Anja Bosy-Westphal
Summary: This study found that higher levels of adiponectin in older adults are associated with lower muscle or bone mass, which may be explained by a decrease in IGF-1 levels.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Marcos Antonio Lopes, Silvia Modesto Nassar, Ricardo Barcelos-Ferreira, Jefferson Cunha Folquitto, Julio Litvoc
Summary: This study estimated the incidence of dementia in a community-dwelling older population from Sao Paulo, Brazil. The research found high incidence rates of dementia, with higher risk of developing Alzheimer's disease for women compared to men. Factors such as age, diabetes, and amnestic Mild Cognitive Impairment (MCI) were identified as increasing the risk of developing dementia.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Nutrition & Dietetics
Moustapha Drame, Lidvine Godaert
Summary: The obesity paradox refers to the counterintuitive finding that older adults who are overweight or obese may have better outcomes in certain diseases compared to those with normal weight or underweight. This systematic review aims to summarize publications on the obesity paradox in older adults and gain a deeper understanding of this phenomenon.
Article
Chemistry, Multidisciplinary
Angel Denche-Zamorano, Diana Salas-Gomez, Jorge Carlos-Vivas, Sabina Barrios-Fernandez, Eugenio Merellano-Navarro, Daniel Collado-Mateo, Pedro R. Olivares, Jose Carmelo Adsuar
Summary: Population growth and physical inactivity have led to negative health and social consequences in the elderly. Research suggests that overweight may not have negative effects on health indicators in older people. This study analysed the associations between Self-Perceived Health, Depression status, Pain Level, and BMI in elderly residents in Spain.
APPLIED SCIENCES-BASEL
(2023)
Article
Geriatrics & Gerontology
Sanne S. Mooldijk, Mohammad Kamran Ikram, Mohammad Arfan Ikram
Summary: This study examined the association between plasma levels of adiponectin, leptin, and resistin with the risk of dementia. The results showed that higher levels of leptin and resistin were associated with a decreased risk of dementia, while adiponectin levels were not associated.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xinhui Wang, Diana Younan, Joshua Millstein, Andrew J. Petkus, Erika Garcia, Daniel P. Beavers, Mark A. Espeland, Helena C. Chui, Susan M. Resnick, Margaret Gatz, Joel D. Kaufman, Gregory A. Wellenius, Eric A. Whitsel, JoAnn E. Manson, Stephen R. Rapp, Jiu-Chiuan Chen
Summary: Improving air quality in old age is associated with a lower risk of dementia in older women.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Geriatrics & Gerontology
Nafisseh S. Warner, Andrew C. Hanson, Phillip J. Schulte, Elizabeth B. Habermann, David O. Warner, Michelle M. Mielke
Summary: The study found that the use of prescription opioids in older adults is associated with small but statistically significant declines in long-term cognitive function. This may represent the effects of opioids themselves or other related factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Critical Care Medicine
Julien Cobert, Sun Young Jeon, John Boscardin, Allyson C. Chapman, Lauren E. Ferrante, Sei Lee, Alexander K. Smith
Summary: The rates of pre-existing disability, frailty, and multimorbidity in older adults admitted to ICUs have increased over time, while the rate of dementia has not significantly changed.
Article
Biochemistry & Molecular Biology
Teresa Pardo-Moreno, Himan Mohamed-Mohamed, Antonio Rivas-Dominguez, Victoria Garcia-Morales, Ruben A. Garcia-Lara, Sami Suleiman-Martos, Beatriz Bermudez-Pulgarin, Juan Jose Ramos-Rodriguez
Summary: Life expectancy has increased but age-associated diseases, especially dementia, have become more prevalent. The development of dementia is influenced by various risk factors, including metabolic pathologies such as obesity and diabetes. However, a high level of education and moderate physical activity are protective factors against cognitive impairment and dementia. In this study, we assessed the metabolic composition of mentally healthy individuals aged 60-90 with high academic degrees. The results indicated that excess body fat was associated with poorer cognitive maintenance, while higher muscle mass percentage was associated with better cognitive abilities.
Article
Dentistry, Oral Surgery & Medicine
Leandro Machado Oliveira, Thayna Regina Pelissari, Carlos Heitor Cunha Moreira, Thiago Machado Ardenghi, Flavio Fernando Demarco, Fabricio Batistin Zanatta
Summary: This study investigated whether the association between alcohol consumption and tooth loss is influenced by socioeconomic positions in Brazilian older adults. The results showed that heavy drinkers with low socioeconomic status and low educational attainment had a higher prevalence of tooth loss compared to their counterparts. This association was confirmed in sensitivity analyses.
Article
Neurosciences
Linda Gjora, Bjorn Heine Strand, Sverre Bergh, Tom Borza, Anne Braekhus, Knut Engedal, Aud Johannessen, Marte Kvello-Alme, Steinar Krokstad, Gill Livingston, Fiona E. Matthews, Christian Myrstad, Havard Skjellegrind, Pernille Thingstad, Eivind Aakhus, Stina Aam, Geir Selbaek
Summary: A large population-based study in Norway found a higher prevalence of dementia and MCI than previous studies. The standardized prevalence of dementia and MCI in individuals aged 70 and above were 14.6% and 35.3% respectively, with dementia being more prevalent in women and MCI more prevalent in men. The most common subtype of dementia identified was Alzheimer's disease. The study projected a significant increase in the number of individuals with dementia in Norway by 2050 and 2100.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Francine Grodstein, Tianhao Wang, Sue E. Leurgans, Robert S. Wilson, David A. Bennett
Summary: This study aimed to investigate the associations between modifiable psychosocial risk factors and the age of onset of Alzheimer's dementia (AD). The results showed that depressive symptoms and neuroticism were associated with an earlier onset of AD, while higher cognitive activity was associated with a delayed onset of AD.
Article
Medicine, General & Internal
Yasuhiro Miyaguni, Takahiro Tabuchi, Jun Aida, Masashige Saito, Taishi Tsuji, Yuri Sasaki, Katsunori Kondo
Summary: The study found that receiving emotional support at the community level is associated with a lower risk of developing incident dementia among older adults. The results showed that a 1% increase in community-level social support was linked to approximately a 4% reduction in the risk of developing dementia. This conclusion has important implications for research and prevention of dementia in older adults.
Article
Nutrition & Dietetics
Bokun Kim, Gwonmin Kim, Yongkook Lee, Keisuke Taniguchi, Tomonori Isobe, Sechang Oh
Summary: This study aimed to investigate the association between the triglyceride-glucose index (TyG index) and sarcopenic obesity (SO), and whether the TyG index could serve as an indicator for SO. The results showed a positive correlation between the TyG index and SO in both genders. Male and female participants in the middle and highest tertiles of the TyG index were 1.775 and 3.369 times more likely to have SO, respectively. The cut-off values for the TyG index to predict SO were >= 8.72 for males and 8.67 for females. In conclusion, the TyG index may be a potential indicator for SO.
Article
Medicine, General & Internal
Minghui Li, Isaac K. Donkor, Rongjie Shao, Stephanie Hsieh, Xiangxiang Jiang, Liang Hong, Z. Kevin Lu
Summary: Distinct subtypes of Alzheimer's disease and related dementias have different effects on dental care usage and costs. Patients with RD were less likely to have treatment visits, while patients with AD had higher total and out-of-pocket costs.
Article
Geriatrics & Gerontology
Luke C. Pilling, Lindsay C. Jones, Jane A. H. Masoli, Joao Delgado, Janice L. Atkins, Jack Bowden, Richard H. Fortinsky, George A. Kuchel, David Melzer
Summary: The study found that low vitamin D levels are associated with an increased risk of hospital-diagnosed delirium in older adults. Both vitamin D deficiency (<25 nmol/L) and insufficiency (25-50 nmol/L) were linked to higher delirium risks, independent of other relevant factors. Genetic analysis also supported a shared causal pathway between vitamin D levels and delirium.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Chia-Ling Kuo, Luke C. Pilling, Janice L. Atkins, Jane A. H. Masoli, Joao Delgado, Christopher Tignanelli, George A. Kuchel, David Melzer, Kenneth B. Beckman, Morgan E. Levine
Summary: The study found that increased biological age, beyond chronological age, is associated with COVID-19 disease severity. More specifically, past estimates of biological age were correlated with increased risk of inpatient test positivity and COVID-19-related mortality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Cara C. Hardy, Iman M. Al-Naggar, Chia-Ling Kuo, George A. Kuchel, Phillip P. Smith
Summary: The study using a lifespan mouse model and related experiments found an increase in heterogeneity of HCN expression in bladder control with aging, which may lead to a decrease in response precision to neuroendocrine control. The results support the role of HCN in neuroendocrine/paracrine integration and suggest a loss of precision in neuroendocrine control associated with aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian'an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellstrom, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Voelker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguez-Manas, Francisco J. Garcia, Jose A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Summary: Low muscle strength is a heritable indicator of poor health in older people, with genetic loci associated with muscle weakness identified through genome-wide meta-analysis. Possible causal relationships with diabetes susceptibility, hematological parameters, and the immune system were also discovered using Mendelian randomization. The distinct mechanisms of muscle weakness from continuous strength were highlighted, shedding light on potential pathways involved in ageing.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Yueying Zhou, Iman M. A. Al-Naggar, Po-Jung Chen, Nathan S. Gasek, Ke Wang, Shivam Mehta, George A. Kuchel, Sumit Yadav, Ming Xu
Summary: Aging is a major risk factor for joint disorders, and TMJ degeneration in older age can significantly impact quality of life without effective treatment options. This study demonstrates that pharmaceutical intervention targeting cellular senescence can alleviate age-related TMJ degeneration, suggesting potential for future clinical trials with senolytics proven to be relatively safe in human studies.
Article
Geriatrics & Gerontology
Emi Ampo, Ana Paula Mendes-Silva, Vanessa Goncalves, Jenna M. Bartley, George A. Kuchel, Breno S. Diniz
Summary: This study evaluated the levels of circulating cell-free mitochondrial DNA (ccf-mtDNA), a marker of cellular stress and damage, in older adults with late-life depression (LLD) and frailty. The coexistence of LLD and frailty was associated with higher levels of ccf-mtDNA, suggesting a common biological mechanism of cellular stress and mitochondrial dysfunction. This finding offers potential opportunities for future interventions guided by geroscience.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Loren M. DeVito, Nir Barzilai, Ana Maria Cuervo, Laura J. Niedernhofer, Sofiya Milman, Morgan Levine, Daniel Promislow, Luigi Ferrucci, George A. Kuchel, Joan Mannick, Jamie Justice, Mitzi M. Gonzales, James L. Kirkland, Pinchas Cohen, Judith Campisi
Summary: Geroscience posits that aging is malleable and by targeting the hallmarks of biological aging, age-related diseases can be alleviated and longevity extended. Experts have made significant advancements in understanding the mechanisms underlying biological aging and identified ways to target aging pathways. Proof-of-concept studies and early-stage clinical trials are underway to assess the feasibility of drug evaluation in geroscience.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Geriatrics & Gerontology
Candace Parker-Autry, Rebecca H. Neiberg, Iris Leng, Lisa Colombo, George A. Kuchel, Stephen B. Kritchevsky
Summary: This study aimed to characterize geriatric incontinence syndrome in older women, finding that women with severe urinary incontinence generally had impaired physical performance, including slower chair stand pace and gait speed.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Felipe Sierra, Avshalom Caspi, Richard H. Fortinsky, Laura Haynes, Gordon J. Lithgow, Terrie E. Moffitt, S. Jay Olshansky, Daniel Perry, Eric Verdin, George A. Kuchel
Summary: Geriatricians and others need to embrace the emerging field of geroscience, which focuses on the modifiability of biological aging and its potential impact on delaying or preventing diseases and disorders. The importance of involving experts from various disciplines to translate geroscience discoveries into clinical care and health policy is emphasized, especially in the context of the current COVID-19 pandemic where biological aging has been identified as one of the key factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Geriatrics & Gerontology
Mina S. Sedrak, James L. Kirkland, Tamar Tchkonia, George A. Kuchel
Summary: The editorial provides commentary on the article written by Siddique and colleagues.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Letter
Geriatrics & Gerontology
Chia-Ling Kuo, Luke C. Pilling, Janice L. Atkins, Richard H. Fortinsky, George A. Kuchel, David Melzer
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cell Biology
Lichao Wang, Binsheng Wang, Nathan S. Gasek, Yueying Zhou, Rachel L. Cohn, Dominique E. Martin, Wulin Zuo, William F. Flynn, Chun Guo, Evan R. Jellison, Taewan Kim, Larissa G. P. Langhi Prata, Allyson K. Palmer, Ming Li, Christina L. Inman, Lauren S. Barber, Iman M. A. Al-Naggar, Yanjiao Zhou, Wenqiang Du, Kshitiz, George A. Kuchel, Alexander Meves, Tamar Tchkonia, James L. Kirkland, Paul Robson, Ming Xu
Summary: This study identifies a small population of p21 high-expressing cells that accumulate in adipose tissue with obesity and shows that intermittent clearance of these cells can prevent and alleviate insulin resistance. Inactivation of the NF-kB pathway within these cells attenuates insulin resistance. Additionally, a drug combination of dasatinib and quercetin can eliminate p21 high-expressing cells in human fat and mitigate insulin resistance.
Article
Nutrition & Dietetics
Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. C. Pilling, George A. A. Kuchel, Richard Kremer, Gustavo Duque
Summary: This study examined the relationship between vitamin D levels and leukocyte telomere length (LTL) in older participants. It found that low or extremely low vitamin D levels were associated with shorter LTL, as well as high vitamin D levels. However, these associations may be influenced by unmeasured confounders.
Review
Cell Biology
Nathan S. Gasek, George A. Kuchel, James L. Kirkland, Ming Xu
Summary: Cellular senescence is a unique cell fate that plays a role in development and wound healing, while also limiting tumor formation. However, the pathologic accumulation of senescent cells is associated with various diseases and age-related morbidities. Research shows that treatments targeting senescent cells through apoptosis induction or inhibition of senescence-related secretory phenotype are beneficial for geriatric decline and chronic diseases.
Article
Biotechnology & Applied Microbiology
Asa Thibodeau, Alper Eroglu, Christopher S. McGinnis, Nathan Lawlor, Djamel Nehar-Belaid, Romy Kursawe, Radu Marches, Daniel N. Conrad, George A. Kuchel, Zev J. Gartner, Jacques Banchereau, Michael L. Stitzel, A. Ercument Cicek, Duygu Ucar
Summary: Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging, but AMULET shows high precision and recall compared to alternatives, especially when a certain read depth of 25K median valid reads per nucleus is achieved.