Article
Gastroenterology & Hepatology
Jakob Ronnow Sand, Frederikke Schonfeldt Troelsen, Erzsebet Horvath-Puho, Victor W. Henderson, Henrik Toft Sorensen, Rune Erichsen
Summary: Inflammatory bowel disease (IBD) is associated with a slightly increased risk of dementia, particularly frontotemporal dementia in patients with Crohn's disease (CD). Frequent healthcare system contacts by IBD patients may play a role in this association.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Neurosciences
Antonios Douros, Christina Santella, Sophie Dell'Aniello, Laurent Azoulay, Christel Renoux, Samy Suissa, Paul Brassard
Summary: The study found that infectious disease burden was associated with an increased risk of Alzheimer's disease (AD), with the risk gradually increasing with longer time since first infection. However, the risk did not increase with cumulative number of infections.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Klodian Dhana, Todd Beck, Pankaja Desai, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study estimates the prevalence and number of people living with Alzheimer's disease (AD) dementia in the US. The results show higher prevalence in the east and southeastern regions, with Maryland, New York, and Mississippi having the highest rates. California, Florida, and Texas have the highest number of AD patients. The state- and county-specific estimates can help develop region-specific strategies for care.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Wonjae Sung, Hyuk Sung Kwon, Yeonjae Park, Seung Hyun Kim, Sojeong Park, Dae Ryong Kang, Hojin Choi
Summary: This study analyzed the prevalence of dementia among patients diagnosed with gout in South Korea and found a relatively low prevalence of dementia in patients with gout. The study also found that patients with both gout and dementia were more likely to be women, have a wide range of comorbidities, and be prescribed gout-related medications.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Tosca O. E. de Crom, Marinka Steur, M. Kamran Ikram, M. Arfan Ikram, Trudy Voortman
Summary: This study evaluated the association between plant-based dietary patterns and the risk of dementia. The overall results showed no strong evidence for a relationship between plant-based eating and the risk of dementia. However, stratified analyses revealed a linear association between a healthy plant-based diet and a lower risk of dementia in men and APOE ε4 carriers, while a U-shaped association was found in APOE ε4 non-carriers.
Article
Geriatrics & Gerontology
Nicolas Kerckhove, Nadege Bornier, Aurelien Mulliez, Antoine Elyn, Sarah Teixeira, Nicolas Authier, Celian Bertin, Chouki Chenaf
Summary: The prevalence of chronic pain among individuals with Alzheimer's disease or related dementia is at least the same as or better than individuals without the disease, highlighting the need for effective pain assessment and management in this population.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Tung-Min Yu, Ya-Wen Chuang, Shih-Ting Huang, Jin-An Huang, Cheng-Hsu Chen, Mu-Chi Chung, Chun-Yi Wu, Pi-Yi Chang, Chih-Cheng Hsu, Ming-Ju Wu
Summary: Exposure to contrast media is significantly associated with the risk of dementia, with a particularly high risk of Alzheimer's disease in younger patients without underlying comorbidities.
Article
Clinical Neurology
Dan-Dan Zhang, Ya-Nan Ou, Liu Yang, Ya-Hui Ma, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used data from the UK Biobank to investigate the association between cancer status and the risk of dementia. The results showed that cancer patients had a lower risk of dementia, especially in those with cancers in the male genital system. Non-melanoma skin cancer and prostate cancer were also associated with a reduced risk of dementia.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Cecilia H. Fuglsang, David Nagy, Frederikke S. Troelsen, Dora K. Farkas, Victor W. Henderson, Henrik T. Sorensen
Summary: Patients with dementia have an increased risk of cancer diagnosis during the first year following VTE, possibly due to increased surveillance, with a lower risk thereafter. The overall risk is similar to that of the general population.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Article
Clinical Neurology
Anisa Dhana, Charles S. S. DeCarli, Klodian Dhana, Pankaja Desai, Thomas M. M. Holland, Denis A. A. Evans, Kumar B. B. Rajan
Summary: The aim of this study was to evaluate the association between cardiovascular health (CVH) and cognitive outcomes, including incident Alzheimer's dementia, rate of cognitive decline, and measures of brain injury and structure. The results showed that CVH was associated with a lower risk of Alzheimer's dementia, slower rate of cognitive decline, and less volume (injury) in white matter hyperintensities.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Oscar Hou In Chou, Jiandong Zhou, Lifang Li, Jeffrey Shi Kai Chan, Danish Iltaf Satti, Vanessa Hou Cheng Chou, Wing Tak Wong, Sharen Lee, Bernard Man Yung Cheung, Gary Tse, Carlin Chang, Tong Liu
Summary: This retrospective population-based cohort study aimed to explore the association between neutrophil-to-lymphocyte ratio (NLR) and dementia. The results showed that patients with NLR >5.44 had an increased risk of developing Alzheimer's disease and related dementia, but not non-Alzheimer's dementia. Utilizing baseline NLR during family medicine consultation may help predict the risks of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Jet M. J. Vonk, Jacoba P. Greving, Vilmundur Gudnason, Lenore J. Launer, Mirjam I. Geerlings
Summary: The study aimed to evaluate the external performance of prediction models for dementia or AD in the general population. Models with cognitive testing as a predictor showed better predictive performance, while calibration across all models ranged from good to poor, indicating potential risk overestimation for some models. Updating existing models or developing new ones for accurately identifying high-risk individuals is needed, along with more external validation studies on dementia prediction models.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Clinical Neurology
Le Zhang, Ebba Du Rietz, Ralf Kuja-Halkola, Maja Dobrosavljevic, Kristina Johnell, Nancy L. Pedersen, Henrik Larsson, Zheng Chang
Summary: The study found an intergenerational association between attention-deficit/hyperactivity disorder (ADHD) and Alzheimer's disease (AD) and other forms of dementia and neurodegenerative diseases, with the association weakening with decreasing genetic relatedness.
ALZHEIMERS & DEMENTIA
(2022)
Article
Gerontology
Serena Sabatini, Anthony Martyr, Laura D. Gamble, Rachel Collins, Fiona E. Matthews, Robin G. Morris, Jennifer M. Rusted, Claire Pentecost, Catherine Quinn, Linda Clare
Summary: This study examines the involvement of people with dementia in everyday decision-making and the factors that explain the variability in their involvement. The results show that female, single, and younger people with dementia tend to have greater involvement in everyday decision-making. Factors such as better cognition, fewer functional difficulties, fewer neuropsychiatric symptoms, less caregiver stress, and better relationship quality are associated with higher involvement in everyday decision-making.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Review
Neurosciences
Hamidul Huque, Ranmalee Eramudugolla, Benjamin Chidiac, Nicole Ee, Lauren Ehrenfeld, Fiona E. Matthews, Ruth Peters, Kaarin J. Anstey
Summary: This study examines sex differences in the incidence and prevalence of dementia globally, and evaluates whether country-level indicators of gender inequality account for these differences. The results show that there are no sex differences in the incidence of dementia, Alzheimer's disease, and vascular dementia, except in the 90+ age group. However, the prevalence of Alzheimer's disease is higher in women, and this difference is associated with gender differences in life expectancy and education.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Vilde Hatlevoll Stensrud, Lise Tuset Gustad, Jan Kristian Damas, Erik Solligard, Steinar Krokstad, Tom Ivar Lund Nilsen
Summary: This study finds that socioeconomic status is inversely associated with sepsis risk and mortality. Approximately 80% of the effect of education on sepsis risk can be explained by modifiable lifestyle and health-related factors, such as smoking, alcohol consumption, and risk factors of cardiovascular disease and chronic diseases.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Geriatrics & Gerontology
Connor D. Richardson, Hannah Roscoe, Emma Green, Racheal Brooks, Linda Barnes, Fiona E. Matthews, Carol Brayne
Summary: The prevalence of loneliness among older people has increased during the COVID-19 pandemic compared to before. Factors associated with prevalent loneliness include prior loneliness, living alone, being female, living in a deprived area, separation from family during the pandemic, and frequent pre-pandemic social contact at community groups. Weekly technology-mediated contact using telephone or video calls is associated with lower odds of loneliness.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Asri Maharani, David R. Sinclair, Tarani Chandola, Peter Bower, Andrew Clegg, Barbara Hanratty, James Nazroo, Neil Pendleton, Gindo Tampubolon, Chris Todd, Raphael Wittenberg, Terence W. O'Neill, Fiona E. Matthews
Summary: This study investigated the relationship between household wealth and neighborhood deprivation with frailty status, and found that individuals with lower wealth and living in deprived neighborhoods are at a higher risk of frailty.
Article
Clinical Neurology
Richard Merrick, Fiona E. Matthews
Summary: A new study on neuropathology trends in autopsy results from two large US cohorts reveals the declining incidence of dementia. While the prevalence of neurodegenerative pathologies remained similar, a reduction in vascular pathologies suggests that improvements in cardiovascular health and cognitive reserve contribute to reducing dementia risk. This study on postmortem neuropathology trends over the past 25 years provides important insights into secular trends in dementia risk, highlighting the role of cardiovascular health and cognitive reserve in the reduced risk.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Chemistry, Analytical
Astrid Ustad, Aleksej Logacjov, Stine Overengen Trollebo, Pernille Thingstad, Beatrix Vereijken, Kerstin Bach, Nina Skjaeret Maroni
Summary: Activity monitoring combined with machine learning can provide detailed knowledge about daily physical behavior in older adults. This study evaluated the performance of two machine learning models in classifying daily physical behavior in older adults, and found that overall accuracy was high for both models.
Article
Clinical Neurology
Heidi Vihovde Sandvig, Stina Aam, Katinka Nordheim Alme, Torunn Askim, Mona K. Beyer, Hanne Ellekjaer, Hege Ihle-Hansen, Stian Lydersen, Tom Eirik Mollnes, Ragnhild Munthe-Kaas, Halvor Naess, Ingvild Saltvedt, Yngve Muller Seljeseth, Pernille Thingstad, Torgeir Wethal, Anne-Brita Knapskog
Summary: This study investigated the association between concentrations of systemic inflammatory biomarkers after ischemic stroke and poststroke cognitive impairment. The results showed that higher concentrations of plasma inflammatory biomarkers, especially those measured in the acute phase following stroke, were significantly associated with lower MoCA scores up to 36 months poststroke.
Article
Clinical Neurology
Mohammed D. Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E. Matthews, Li Su, Paul G. Ince, Stephen B. Wharton, Dennis Wang
Summary: This study applies machine learning approaches to identify critical features of Alzheimer-related pathologies associated with dementia. Results show that Braak neurofibrillary tangle stage, beta-amyloid, and cerebral amyloid angiopathy are the most important features for dementia classification. The best-performing dementia classifier achieved 79% sensitivity, 69% specificity, and 75% precision using the top eight neuropathological features.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Geriatrics & Gerontology
Anum Iqbal, Charlotte Richardson, Zain Iqbal, Hannah O'Keefe, Barbara Hanratty, Fiona E. Matthews, Adam Todd
Summary: This article conducted a systematic review and meta-analysis to investigate the association between polypharmacy and an individual's socioeconomic status. It found that older people with lower socioeconomic status are more likely to use multiple medications. Future research should further explore the reasons for these inequalities and the interplay between polypharmacy and multimorbidity.
Editorial Material
Medicine, General & Internal
Gill Livingston, Sergi G. Costafreda
Article
Public, Environmental & Occupational Health
Bodil Elisabeth Valstad Aasan, Monica Lillefjell, Steinar Krokstad, Erik R. Sund
Summary: The study finds increasing socioeconomic inequalities in psychological distress and loneliness among Norwegian adolescents. Regardless of parental education level, the family appears to be an important arena for preventing psychological distress and loneliness among adolescents.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Bente Irene Lokken, Erik R. Sund, Steinar Krokstad, Ottar Bjerkeset, Vegar Rangul
Summary: This study found that engagement in creative or combined receptive and creative cultural activities was associated with lower numbers of GP consultations among men. This suggests that promoting a culturally engaged lifestyle, especially in men, may impact their use of primary healthcare. However, the study design does not provide evidence of a causal relationship between cultural engagement and GP consultations.
Article
Nutrition & Dietetics
Marit Kolberg, Ingvild Paur, Yi-Qian Sun, Linda Gjora, Harvard Kjesbu Skjellegrind, Pernille Thingstad, Bjorn Heine Strand, Geir Selbaek, Tone Natland Fagerhaug, Lene Thoresen
Summary: The aim of this study is to describe the prevalence of malnutrition in older adults, based on low BMI, involuntary weight loss, and reduced food intake. The study found that the prevalence of malnutrition is high in the older population, particularly among women and the oldest age groups. Malnutrition was also associated with low BMI, weight loss, and reduced food intake.
CLINICAL NUTRITION ESPEN
(2023)
Review
Neurosciences
Ruan-Ching Yu, Jen-Chieh Lai, Esther K. Hui, Naaheed Mukadam, Narinder Kapur, Joshua Stott, Gill Livingston
Summary: This study conducted a systematic review and meta-analysis of brief cognitive tests adapted for Chinese-speaking populations with suspected dementia. The results showed that ACE-R and ACE-III are the best brief cognitive assessments for dementia and mild cognitive impairment in Chinese-speaking populations.
JOURNAL OF ALZHEIMERS DISEASE REPORTS
(2023)