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Biology
Alaattin Kaya, Cheryl Zi Jin Phua, Mitchell Lee, Lu Wang, Alexander Tyshkovskiy, Siming Ma, Benjamin Barre, Weiqiang Liu, Benjamin R. Harrison, Xiaqing Zhao, Xuming Zhou, Brian M. Wasko, Theo K. Bammler, Daniel E. L. Promislow, Matt Kaeberlein, Vadim N. Gladyshev
Summary: This study explored replicative lifespan diversity among diverse wild yeast isolates, identifying genetic networks and novel genes, metabolites, and pathways associated with natural variation in lifespan. Furthermore, it revealed unique adaptations in long-lived strains to interconnected amino acid biosynthesis, glutamate metabolism, and mitochondrial function. Overall, the research demonstrates how gene-environment interactions shape cellular processes involved in phenotypic variation such as lifespan.
Review
Cell Biology
Mario G. Mirisola, Valter D. Longo
Summary: S. cerevisiae plays a crucial role as a model organism in understanding mammalian biochemistry and molecular biology. The study of its chronological lifespan provides insights into age-related damage and longevity extension. It also serves as a model system to study macromolecular and cellular damage leading to diseases and investigate the effects of nutrients and dietary regimens on stress resistance and longevity.
Article
Biology
David M. Garcia, Edgar A. Campbell, Christopher M. Jakobson, Mitsuhiro Tsuchiya, Ethan A. Shaw, Acadia L. DiNardo, Matt Kaeberlein, Daniel F. Jarosz
Summary: This study reveals a natural example of how the interplay between growth and lifespan can be epigenetically controlled through a RNA-modifying enzyme acting as a prion in yeast cells, leading to increased proliferation rates but shortened lifespan. The epigenetic state, [B/G(+)], allows cells to heritably alter their translational program, resulting in differential synthesis of proteins that regulate proliferation and aging.
Review
Cell Biology
Zheng Zhou, Bao Sun, Dongsheng Yu, Meng Bian
Summary: tRNAs, traditionally seen as housekeepers, are now known to play important roles in various physiological and pathological processes, including aging and lifespan regulation.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Richard Campion, Leanne Bloxam, Kimberley Burrow, Philip J. Brownridge, Daniel R. Pentland, Patricia Thomas, Campbell W. Gourlay, Claire E. Eyers, Jeff W. Barclay, Alan Morgan
Summary: Dietary restriction (DR) can increase replicative lifespan in yeast by enhancing mitochondrial respiration and affecting the expression of certain proteins, while also inhibiting mating in yeast. These changes may be related to proteins associated with the heat shock protein (HSP) family.
BIOCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Mrinal Sharma, Prranshu Yadav, Ankita Doshi, Hemang D. Brahmbhatt, C. Ratna Prabha
Summary: The study examined the effects of six double mutants derived from the ubiquitin mutant UbEP42 on cell functions, finding that the double mutation L50P-I61T had the most detrimental impact. Overall, these double mutations made cells more sensitive, and the negative effects under certain conditions could be compensated for by each other.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Manuel Hotz, Nathaniel H. Thayer, David G. Hendrickson, Elizabeth L. Schinski, Jun Xu, Daniel E. Gottschling
Summary: This study discovered a previously unappreciated relationship between the number of copies of the ribosomal RNA gene and the replicative lifespan in budding yeast. The data suggest that regulatory mechanisms involving ribosomal DNA copy number limit lifespan and changes in rDNA copy number might explain the effects of lifespan-enhancing mutations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Water Resources
Mohaddeseh Zahmatkesh Anbarani, Afsaneh Esmaeili Nasrabadi, Ziaeddin Bonyadi
Summary: The aim of this study was to evaluate the efficiency of S. cerevisiae in removing PS from aqueous solutions. BBD was used to determine the optimal removal conditions. The maximum PS removal efficiency was 98.81% under optimized conditions. Based on the results, it can be concluded that S. cerevisiae can be used as a natural and environmentally friendly biocoagulant to remove PS.
APPLIED WATER SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Yingying Wang, Zhen Zhu, Ke Liu, Qin Xiao, Yangye Geng, Feng Xu, Shuiping Ouyang, Ke Zheng, Yimin Fan, Nan Jin, Xiangwei Zhao, Mario A. Marchisio, Dejing Pan, Qing-An Huang
Summary: In this study, a high-throughput microfluidic chip for diploid yeast long-term culturing, optical inspection, and cell-aging analysis was developed. The chip features delicate microstructures to ensure cell stability and alleviate stress. Using this chip, the researchers were able to track the replicative lifespan and budding time interval of diploid yeast cells and observe cell desynchronization during aging.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
C. K. Odoh, R. Kamal, H. Xue, L. Lyu, J. T. Arnone, Z. K. Zhao
Summary: Glucosylglycerol (GG) is an osmolyte that protects cells from extreme conditions. This study confirms that moderate doses of GG can extend the lifespan of yeast by increasing the osmolarity of the culture medium. The mechanism underlying this longevity promotion involves the modulation of reactive oxygen species (ROS) generation.
INDIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Food Science & Technology
Jitka Laurent, Nore Struyf, An Bautil, Albina Bakeeva, Mikolaj Chmielarz, Marika Lyly, Beatriz Herrera-Malaver, Volkmar Passoth, Kevin J. Verstrepen, Christophe M. Courtin
Summary: A diet low in FODMAPs can help reduce symptoms in patients with irritable bowel syndrome, but avoiding cereal grain products may lead to nutritional deficiencies. Developing low-FODMAP, high-fiber cereal grain products using K. marxianus in bread production can effectively reduce fructan levels and maintain fructan and fructose levels below the threshold for low-FODMAP products.
FOOD AND BIOPROCESS TECHNOLOGY
(2021)
Article
Genetics & Heredity
Raquel Sorribes-Dauden, Maria Teresa Martinez-Pastor, Sergi Puig
Summary: Iron is essential for eukaryotic organisms, and its deficiency can lead to anemia. Yeast cells use the Ccc1 transporter to detoxify and store excess iron. Deletion of the Nt domain of Ccc1 can increase iron accumulation in cells.
Article
Immunology
Francesca Soutter, Dirk Werling, Matthew Nolan, Tatiana Kuster, Elizabeth Attree, Virginia Marugan-Hernandez, Sungwon Kim, Fiona M. Tomley, Damer P. Blake
Summary: A cheap and easy-to-produce oral vaccine has been developed using Saccharomyces cerevisiae yeast expressing Eimeria tenella antigens. The vaccine effectively reduces the replication of Eimeria tenella and improves the growth of chickens, making it an important tool for controlling coccidiosis in chickens, particularly in low- and middle-income countries.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Bazile Ravoityte, Juliana Luksa, Ralf Erik Wellinger, Saulius Serva, Elena Serviene
Summary: This study analyzed the impact of L-A virus on gene expression in yeast hosts using high-throughput RNA sequencing data. It was found that the presence of L-A virus resulted in moderate alterations in gene expression, particularly in genes involved in ribosome biogenesis. Additionally, the transcriptional responses to L-A maintenance were similar to those induced by stress or nutrient availability. The study also identified yeast transcriptional regulators that modulate the levels of L-A dsRNA in cells.
Review
Biotechnology & Applied Microbiology
R. Sahaya Glingston, Jyoti Yadav, Jitika Rajpoot, Neha Joshi, Shirisha Nagotu
Summary: Yeast has been proven to be a valuable model system for studying viral infection and expression of viral proteins, advancing our understanding of important viruses. Through high-throughput analysis, genetic manipulation, and its compact genome, yeast provides insights into various aspects related to virus replication.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leszek Wawiorka, Eliza Molestak, Monika Szajwaj, Barbara Michalec-Wawiorka, Mateusz Molon, Lidia Borkiewicz, Przemyslaw Grela, Aleksandra Boguszewska, Marek Tchorzewski
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Cell Biology
Mateusz Molon, Anita Panek, Eliza Molestak, Marek Skoneczny, Marek Tchorzewski, Maciej Wnuk
Article
Behavioral Sciences
Roma Durak, Mateusz Molon, Tomasz Durak, Grzegorz Chrzanowski
ETHOLOGY ECOLOGY & EVOLUTION
(2018)
Article
Biochemical Research Methods
Roman Maslanka, Magdalena Kwolek-Mirek, Renata Zadrag-Tecza
JOURNAL OF MICROBIOLOGICAL METHODS
(2018)
Article
Cell Biology
Renata Zadrag-Tecza, Magdalena Kwolek-Mirek, Malgorzata Alabrudzinska, Adrianna Skoneczna
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Biochemistry & Molecular Biology
Magdalena Kwolek-Mirek, Roman Maslanka, Mateusz Molon
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Roman Maslanka, Renata Zadrag-Tecza
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Lidia Borkiewicz, Mateusz Molon, Eliza Molestak, Przemyslaw Grela, Patrycja Horbowicz-Drozdzal, Leszek Wawiorka, Marek Tchorzewski
Article
Biochemistry & Molecular Biology
Roman Maslanka, Renata Zadrag-Tecza
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Multidisciplinary Sciences
Tomasz Bilinski, Aneta Bylak, Krzysztof Kukula, Renata Zadrag-Tecza
Summary: Most common terrestrial animal clades, such as insects, mammals, and birds, exhibit senescence despite evolving from ancestors that did not show signs of aging. Additionally, secondarily aquatic animals show a lower rate of senescence compared to terrestrial counterparts. Aging has evolved as a correlated response of selection on developmental strategies within each clade, and specific life history strategies can have significant effects on senescence and lifespan. The emergence of senescence may have been a side effect of the evolution of adaptive features that allowed the colonization of land, with potential implications for understanding the evolution of aging in different animal clades.
Article
Geriatrics & Gerontology
Mateusz Molon, Olga Woznicka, Jacek Zebrowski
Article
Biotechnology & Applied Microbiology
Roman Maslanka, Magdalena Kwolek-Mirek, Renata Zadrag-Tecza
FEMS YEAST RESEARCH
(2017)
Article
Biotechnology & Applied Microbiology
Mateusz Molon, Jacek Zebrowski
FEMS YEAST RESEARCH
(2017)
Article
Geriatrics & Gerontology
Tomasz Bilinski, Aneta Bylak, Renata Zadrag-Tecza