A prion accelerates proliferation at the expense of lifespan

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase

(2020) Sandra Catania et al.   CELL

Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae

(2019) Christopher M. Jakobson et al.   Nature Communications

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

(2019) Gabriel E. Neurohr et al.   CELL

Molecular Origins of Complex Heritability in Natural Genotype-to-Phenotype Relationships

(2019) Christopher M. Jakobson et al.   Cell Systems

Sensitive and quantitative probing of pseudouridine modification in mRNA and long non-coding RNA

(2019) Wen Zhang et al.   RNA

Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae

(2019) Alan K. Itakura et al.   MOLECULAR CELL

A Non-amyloid Prion Particle that Activates a Heritable Gene Expression Program

(2019) Anupam K. Chakravarty et al.   MOLECULAR CELL

Mapping Causal Variants with Single-Nucleotide Resolution Reveals Biochemical Drivers of Phenotypic Change

(2018) Richard She et al.   CELL

Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals

(2018) Shira Anzi et al.   DEVELOPMENTAL CELL

Protein-Based Inheritance: Epigenetics beyond the Chromosome

(2018) Zachary H. Harvey et al.   MOLECULAR CELL

Genome-wide SWAp-Tag yeast libraries for proteome exploration

(2018) Uri Weill et al.   NATURE METHODS

Codon usage of highly expressed genes affects proteome-wide translation efficiency

(2018) Idan Frumkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Control in Cancer

(2018) Nathaniel Robichaud et al.   Cold Spring Harbor Perspectives in Biology

Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing

(2018) Eilon Sharon et al.   CELL

Feedback regulation of TORC1 by its downstream effectors Npr1 and Par32

(2018) Natalia V. Varlakhanova et al.   MOLECULAR BIOLOGY OF THE CELL

Saccharomyces cerevisiae adapted to grow in the presence of low-dose rapamycin exhibit altered amino acid metabolism

(2018) Duygu Dikicioglu et al.   Cell Communication and Signaling

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code

(2017) Modi Safra et al.   GENOME RESEARCH

Differential analysis of RNA-seq incorporating quantification uncertainty

(2017) Harold Pimentel et al.   NATURE METHODS

A bacterial global regulator forms a prion

(2017) Andy H. Yuan et al.   SCIENCE

Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits

(2016) Sohini Chakrabortee et al.   CELL

A Ribosomal Perspective on Proteostasis and Aging

(2016) Kristan K. Steffen et al.   Cell Metabolism

A Deafness- and Diabetes-associated tRNA Mutation Causes Deficient Pseudouridinylation at Position 55 in tRNAGluand Mitochondrial Dysfunction

(2016) Meng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pseudouridylation meets next-generation sequencing

(2016) Maryam Zaringhalam et al.   METHODS

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

(2016) Ido Yofe et al.   NATURE METHODS

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Luminidependens (LD) is an Arabidopsis protein with prion behavior

(2016) Sohini Chakrabortee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fitness landscape of a tRNA gene

(2016) C. Li et al.   SCIENCE

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Cost of Protein Production

(2016) Moshe Kafri et al.   Cell Reports

A common bacterial metabolite elicits prion-based bypass of glucose repression

(2016) David M Garcia et al.   eLife

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Longevity GWAS Using theDrosophilaGenetic Reference Panel

(2015) Dobril K. Ivanov et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1.

(2015) Alessandro Bitto et al.   Cold Spring Harbor Perspectives in Medicine

Why Is Aging Conserved and What Can We Do about It?

(2015) Jason N. Pitt et al.   PLOS BIOLOGY

Regulation of mRNA translation during mitosis

(2015) Marvin E Tanenbaum et al.   eLife

Protein biogenesis machinery is a driver of replicative aging in yeast

(2015) Georges E Janssens et al.   eLife

An Evolutionarily Conserved Prion-like Element Converts Wild Fungi from Metabolic Specialists to Generalists

(2014) Daniel F. Jarosz et al.   CELL

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

(2014) Schraga Schwartz et al.   CELL

Stress-dependent Proteolytic Processing of the Actin Assembly Protein Lsb1 Modulates a Yeast Prion

(2014) Moiez Ali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for the proteasome in the turnover of Sup35p and in [PSI+] prion propagation

(2014) Mehdi Kabani et al.   MOLECULAR MICROBIOLOGY

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

(2014) Thomas M. Carlile et al.   NATURE

Transcriptome-Wide Mapping of Pseudouridines: Pseudouridine Synthases Modify Specific mRNAs in S. cerevisiae

(2014) Alexander F. Lovejoy et al.   PLoS One

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Genome-wide Translational Changes Induced by the Prion [PSI+]

(2014) Agnès Baudin-Baillieu et al.   Cell Reports

Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

(2014) Chong He et al.   PLoS Genetics

High-Resolution Profiling of Stationary-Phase Survival Reveals Yeast Longevity Factors and Their Genetic Interactions

(2014) Erika Garay et al.   PLoS Genetics

Pernicious Pathogens or Expedient Elements of Inheritance: The Significance of Yeast Prions

(2014) James S. Byers et al.   PLoS Pathogens

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

Translation elongation can control translation initiation on eukaryotic mRNAs

(2013) Dominique Chu et al.   EMBO JOURNAL

RESTRICTED PLEIOTROPY FACILITATES MUTATIONAL EROSION OF MAJOR LIFE-HISTORY TRAITS

(2013) Agnieszka Marek et al.   EVOLUTION

Rebels with a cause: molecular features and physiological consequences of yeast prions

(2013) David M. Garcia et al.   FEMS YEAST RESEARCH

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Cell Size Control in Yeast

(2012) Jonathan J. Turner et al.   CURRENT BIOLOGY

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

Prions are a common mechanism for phenotypic inheritance in wild yeasts

(2012) Randal Halfmann et al.   NATURE

NCBI GEO: archive for functional genomics data sets—update

(2012) Tanya Barrett et al.   NUCLEIC ACIDS RESEARCH

A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress

(2012) G. Suzuki et al.   SCIENCE

Environmental Regulation of Prions in Yeast

(2012) Liming Li et al.   PLoS Pathogens

Mechanisms for the Inheritance of Chromatin States

(2011) Danesh Moazed   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cell size and growth rate are major determinants of replicative lifespan

(2011) Jingye Yang et al.   CELL CYCLE

Determinants of translation efficiency and accuracy

(2011) H. Gingold et al.   Molecular Systems Biology

Composition and Acidification of the Culture Medium Influences Chronological Aging Similarly in Vineyard and Laboratory Yeast

(2011) Christopher J. Murakami et al.   PLoS One

Natural Polymorphism in BUL2 Links Cellular Amino Acid Availability with Chronological Aging and Telomere Maintenance in Yeast

(2011) Elizabeth X. Kwan et al.   PLoS Genetics

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

(2010) Tamir Tuller et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

(2010) Laura Kapitzky et al.   Molecular Systems Biology

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

Genome-wide measurement of RNA secondary structure in yeast

(2010) Michael Kertesz et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Generation of a large set of genetically tractable haploid and diploidSaccharomyces strains

(2009) Francisco A. Cubillos et al.   FEMS YEAST RESEARCH

A heritable switch in carbon source utilization driven by an unusual yeast prion

(2009) J. C.S. Brown et al.   GENES & DEVELOPMENT

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

DRYGIN: a database of quantitative genetic interaction networks in yeast

(2009) Judice L. Y. Koh et al.   NUCLEIC ACIDS RESEARCH

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Measuring Replicative Life Span in the Budding Yeast

(2009) Kristan K. Steffen et al.   Jove-Journal of Visualized Experiments

The discovery of polyribosomes

(2008) Hans Noll   BIOESSAYS

Cell volume as a factor limiting the replicative lifespan of the yeast Saccharomyces cerevisiae

(2008) Renata Zadrag-Tecza et al.   BIOGERONTOLOGY

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome

(2008) David K Breslow et al.   NATURE METHODS