Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway

Transcriptional outcome of telomere signalling

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IGF1 promotes osteogenic differentiation of mesenchymal stem cells derived from rat bone marrow by increasing TAZ expression

(2013) Peng Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

(2011) Bruno Bernardes de Jesus et al.   AGING CELL

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment

(2011) Hamid Saeed et al.   JOURNAL OF BONE AND MINERAL RESEARCH

EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis

(2010) Steffen Heeg et al.   CANCER SCIENCE

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Tumor Necrosis Factor Receptor Superfamily Member 19 (TNFRSF19) Regulates Differentiation Fate of Human Mesenchymal (Stromal) Stem Cells through Canonical Wnt Signaling and C/EBP

(2010) Weimin Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1,25-dihydroxyvitamin D3 potentiates fluoride-stimulated collagen type I production in cultures of human bone marrow stromal osteoblast-like cells

(2010) Moustapha Kassem et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Older men with low serum IGF-1 have an increased risk of incident fractures: The MrOS Sweden study

(2010) Claes Ohlsson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

(2010) Sebastio Perrini et al.   JOURNAL OF ENDOCRINOLOGY

Akt promotes BMP2-mediated osteoblast differentiation and bone development

(2009) A. Mukherjee et al.   JOURNAL OF CELL SCIENCE

Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans

(2008) Luigi Laviola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells

(2008) M. Bellon et al.   BLOOD

Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells

(2008) S. Post et al.   BONE

Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms

(2008) L Xia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Growth Hormone, Insulin-Like Growth Factors, and the Skeleton

(2008) Andrea Giustina et al.   ENDOCRINE REVIEWS

IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women

(2008) Jian-min Liu et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Role of Insulin-Like Growth Factor Binding Protein-3 in Human Umbilical Vein Endothelial Cell Senescence

(2008) Christoph Muck et al.   REJUVENATION RESEARCH

Insulin-like growth factor-binding proteins and bone metabolism

(2007) Cheryl A. Conover   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Abnormalities of Insulin-Like Growth Factor-I Signaling and Impaired Cell Proliferation in Osteoblasts from Subjects with Osteoporosis

(2007) Sebastio Perrini et al.   ENDOCRINOLOGY

Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways

(2007) Angela Raucci et al.   JOURNAL OF CELLULAR PHYSIOLOGY