期刊
BIOESSAYS
卷 38, 期 2, 页码 129-139出版社
WILEY
DOI: 10.1002/bies.201500150
关键词
lipids; membrane heterogeneity; membrane proteins; membrane rafts; phase separation; plasma membrane; raft hypothesis
资金
- Austrian Science Fund (FWF) [P26337-B21, P25730-B21]
- Austrian Research Promotion Agency FFG [842379]
- Austrian Science Fund (FWF) [P26337] Funding Source: Austrian Science Fund (FWF)
The fundamental mechanisms of protein and lipid organization at the plasma membrane have continued to engage researchers for decades. Among proposed models, one idea has been particularly successful which assumes that sterol-dependent nanoscopic phases of different lipid chain order compartmentalize proteins, thereby modulating protein functionality. This model of membrane rafts has sustainably sparked the fields of membrane biophysics and biology, and shifted membrane lipids into the spotlight of research; by now, rafts have become an integral part of our terminology to describe a variety of cell biological processes. But is the evidence clear enough to continue supporting a theoretical concept which has resisted direct proof by observation for nearly twenty years? In this essay, we revisit findings that gave rise to and substantiated the raft hypothesis, discuss its impact on recent studies, and present alternative mechanisms to account for plasma membrane heterogeneity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据