Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging inCaenorhabditis elegans

Lifespan and healthspan extension by resveratrol

(2015) Khushwant S. Bhullar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

(2015) Claire E. Schaar et al.   PLoS Genetics

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

(2015) Naïg Gueguen et al.   PLoS One

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Metabolic effects of resveratrol: addressing the controversies

(2014) Jacob L. Bitterman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Promise and Perils of Antioxidants for Cancer Patients

(2014) Navdeep S. Chandel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity inCaenorhabditis elegans

(2014) Ara B. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

Quantification ofin vivooxidative damage inCaenorhabditis elegansduring aging by endogenous F3-isoprostane measurement

(2012) Christiaan F. Labuschagne et al.   AGING CELL

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol and life extension

(2011) Beamon Agarwal et al.   Annals of the New York Academy of Sciences

FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1

(2011) Jeremy Michael Van Raamsdonk et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?

(2010) Jeremy Michael Van Raamsdonk et al.   ANTIOXIDANTS & REDOX SIGNALING

Differential Effects of Resveratrol and SRT1720 on Lifespan of AdultCaenorhabditis elegans

(2010) K. Zarse et al.   HORMONE AND METABOLIC RESEARCH

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan

(2009) Ayumi Shibamura et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Resveratrol opposite effects on rat tissue lipoperoxidation: pro-oxidant during day-time and antioxidant at night

(2009) Wafa Gadacha et al.   REDOX REPORT

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

The C. elegans glycosyltransferase BUS-8 has two distinct and essential roles in epidermal morphogenesis

(2008) Frederick A. Partridge et al.   DEVELOPMENTAL BIOLOGY

A theoretical antioxidant pharmacophore for resveratrol

(2008) Auriekson N. Queiroz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY