期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 2, 页码 195-200出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500862
关键词
azalactones; dihydrocoumarins; lactonization; Michael addition; ortho-nitrovinylphenols
资金
- National Natural Science Foundation of China [21421062]
- Key Laboratory of Elemento-Organic Chemistry
- Collaborative Innovation Center of Chemical Science and Engineering
An asymmetric tandem Michael addition-lactonization between ortho-nitrovinylphenols and azalactones was investigated for constructing 3,4-dihydrocoumarin backbones with a quaternary amino acid moiety. Under the catalysis of the chiral squaramide derived from l-tert-leucine, a wide range of substituted (E)-2-(2-nitrovinyl)phenols and azalactones were well tolerated in this tandem reaction to provide the corresponding biologically significant 3,4-dihydrocoumarin derivatives in excellent yields with high levels of diastereo- and enantioselectivity.
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