Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

The gut microbiota and metabolic disease: current understanding and future perspectives

(2016) T. Arora et al.   JOURNAL OF INTERNAL MEDICINE

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes

(2016) Jill L Sherriff et al.   Advances in Nutrition

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Biochemical Characterization of a Pseudomonas aeruginosa Phospholipase D

(2015) Cierra Spencer et al.   BIOCHEMISTRY

The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides

(2015) Konstantinos D. Tsirigos et al.   NUCLEIC ACIDS RESEARCH

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Discovery of Desketoraloxifene Analogues as Inhibitors of Mammalian, Pseudomonas aeruginosa, and NAPE Phospholipase D Enzymes

(2014) Sarah A. Scott et al.   ACS Chemical Biology

Characterization of Choline Trimethylamine-Lyase Expands the Chemistry of Glycyl Radical Enzymes

(2014) Smaranda Craciun et al.   ACS Chemical Biology

First Multicenter Study of Modified Release Phosphatidylcholine “LT-02” in Ulcerative Colitis: A Randomized, Placebo-Controlled Trial in Mesalazine-Refractory Courses

(2014) Max Karner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor

(2014) Letícia MS Lery et al.   BMC BIOLOGY

A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells

(2014) Feng Jiang et al.   Cell Host & Microbe

Finding the balance: The role ofS-adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease

(2013) René L. Jacobs et al.   HEPATOLOGY

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

(2012) S. Craciun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

(2011) Karen D. Corbin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Gut microbiome-host interactions in health and disease

(2011) James M Kinross et al.   Genome Medicine

Inactivation of Phospholipase D Diminishes Acinetobacter baumannii Pathogenesis

(2010) A. C. Jacobs et al.   INFECTION AND IMMUNITY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Dietary Phospholipids and Intestinal Cholesterol Absorption

(2010) Jeffrey Cohn et al.   Nutrients

Phospholipase D mechanism using Streptomyces PLD

(2009) Yoshiko Uesugi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Directed Mutagenesis of the Rickettsia prowazekii pld Gene Encoding Phospholipase D

(2009) L. O. Driskell et al.   INFECTION AND IMMUNITY

Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: A clue to pathogenesis

(2009) Annika Braun et al.   INFLAMMATORY BOWEL DISEASES

Choline: an essential nutrient for public health

(2009) Steven H Zeisel et al.   NUTRITION REVIEWS

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

(2008) W. Su et al.   MOLECULAR PHARMACOLOGY

Transmembrane Topology and Signal Peptide Prediction Using Dynamic Bayesian Networks

(2008) Sheila M. Reynolds et al.   PLoS Computational Biology

Cloning, overexpression, and characterization of a bacterial Ca2+-dependent phospholipase D

(2002) Hongying Yang et al.   PROTEIN SCIENCE