Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes

S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease

(2015) Maite Martínez-Uña et al.   JOURNAL OF HEPATOLOGY

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Characterization and Detection of a Widely Distributed Gene Cluster That Predicts Anaerobic Choline Utilization by Human Gut Bacteria

(2015) Ana Martínez-del Campo et al.   mBio

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study

(2014) Carolyn A Miller et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Non-alcoholic fatty liver disease associated with gallstones in females rather than males: a longitudinal cohort study in Chinese urban population

(2014) Jia Liu et al.   BMC GASTROENTEROLOGY

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups

(2014) Kerry-Ann da Costa et al.   FASEB JOURNAL

Higher Dietary Choline Intake Is Associated with Lower Risk of Nonalcoholic Fatty Liver in Normal-Weight Chinese Women

(2014) Danxia Yu et al.   JOURNAL OF NUTRITION

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease

(2014) F. Payne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental models of non-alcoholic fatty liver disease in rats

(2014) Otto Kucera   WORLD JOURNAL OF GASTROENTEROLOGY

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Finding the balance: The role ofS-adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease

(2013) René L. Jacobs et al.   HEPATOLOGY

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Outer Surface Lipoprotein VolA Mediates Utilization of Exogenous Lipids by Vibrio cholerae

(2013) A. C. Pride et al.   mBio

Choline intake in a large cohort of patients with nonalcoholic fatty liver disease

(2012) Anthony L Guerrerio et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

The Membrane Lipid Phosphatidylcholine Is an Unexpected Source of Triacylglycerol in the Liver

(2012) Jelske N. van der Veen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation

(2012) Xuanhe Li et al.   JOURNAL OF LIPID RESEARCH

A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

(2011) Amy K. Walker et al.   CELL

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

(2011) Karen D. Corbin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Lipid droplets: size matters

(2011) M. Suzuki et al.   Microscopy

Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes

(2010) Giovanni Musso et al.   Annual Review of Medicine

Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline

(2010) Wei Sha et al.   FASEB JOURNAL

Splanchnic Balance of Free Fatty Acids, Endocannabinoids, and Lipids in Subjects With Nonalcoholic Fatty Liver Disease

(2010) Jukka Westerbacka et al.   GASTROENTEROLOGY

Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

(2010) Melanie D. Spencer et al.   GASTROENTEROLOGY

Aberrant Estrogen Regulation ofPEMTResults in Choline Deficiency-associated Liver Dysfunction

(2010) Mary E. Resseguie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Choline: an essential nutrient for public health

(2009) Steven H Zeisel et al.   NUTRITION REVIEWS

Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis

(2008) Dennis E Vance   CURRENT OPINION IN LIPIDOLOGY

Thematic Review Series: Glycerolipids.Phosphatidylcholine and choline homeostasis

(2008) Zhaoyu Li et al.   JOURNAL OF LIPID RESEARCH