期刊
ONCOTARGET
卷 8, 期 3, 页码 5619-5628出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13639
关键词
metformin; therapeutic targets; metabolism; epigenetic modifications
资金
- National Nature Science Foundation of China [31671335, 31600046, 31672561]
Metformin has been used to treat type 2 diabetes for over 50 years. Epidemiological, preclinical and clinical studies suggest that metformin treatment reduces cancer incidence in diabetes patients. Due to its potential as an anti-cancer agent and its low cost, metformin has gained intense research interest. Its traditional anti-cancer mechanisms involve both indirect and direct insulin-dependent pathways. Here, we discussed the anti-tumor mechanism of metformin from the aspects of cell metabolism and epigenetic modifications. The effects of metformin on anti-cancer immunity and apoptosis were also described. Understanding these mechanisms will shed lights on application of metformin in clinical trials and development of anticancer therapy.
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