Article
Cell Biology
Liang Peng, Wei Sun, Fanqin Wei, Lin Chen, Weiping Wen
Summary: The study investigated the role of IL-33 in human cutaneous melanoma, revealing its association with better prognosis and more active immune responses in metastasis sub-cohorts, while not serving as a prognostic factor in the primary melanoma sub-cohort. Moreover, the cellular sources of IL-33 may determine its distinct effects.
Review
Biochemistry & Molecular Biology
Bojan Stojanovic, Nevena Gajovic, Milena Jurisevic, Milica Dimitrijevic Stojanovic, Marina Jovanovic, Ivan Jovanovic, Bojana S. Stojanovic, Bojan Milosevic
Summary: IL-33 plays a critical role in breast cancer biology, influencing cancer progression and immune response, and may serve as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Dandan Fu, Shuting Zheng, Jialin Li, Hua Hu, Qingqing Wang, Xiuyu Fu, Min Li, Dong Yan, Zishan Yang, Zhongwei Tian, Xiangfeng Song
Summary: In this study, the effect of anti-IL-33 antibody was evaluated in a mouse model of psoriatic dermatitis. The results showed that anti-IL-33 antibody improved the symptoms of the disease and reduced the expression of psoriasis-related cytokines. Furthermore, treatment with anti-IL-33 antibody inhibited the activation of STAT3 and reduced lymphocyte infiltration in the skin lesions, suggesting IL-33 as a potential therapeutic target for psoriasis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Veronika Lutz, Veronique M. Hellmund, Felix S. R. Picard, Hartmann Raifer, Teresa Ruckenbrod, Matthias Klein, Tobias Bopp, Rajkumar Savai, Peter Duewell, Corinna U. Keber, Andreas Weigert, Ho-Ryun Chung, Malte Buchholz, Andre Menke, Thomas M. Gress, Magdalena Huber, Christian Bauer
Summary: Signaling through IL18R induces exhaustion of CD8(+) T cells, characterized by expression of coinhibitory receptors and loss of effector function. This exhaustion is mediated by an NLRP3-expressing tumor microenvironment that releases IL18. These findings suggest that NLRP3-mediated IL18R signaling could be a potential target for immunotherapy in pancreatic carcinoma.
CANCER IMMUNOLOGY RESEARCH
(2023)
Review
Immunology
Changfa Sun, Bochu Wang, Shilei Hao
Summary: The adenosine-A2AR pathway plays a crucial role in regulating immune responses and tumor progression. Blocking this pathway can inhibit tumor growth and has potential synergistic effects with CAR T cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tanglin Ouyang, Liyu Song, Huiling Fang, Ji Tan, Yue Zheng, Jinping Yi
Summary: Rheumatoid arthritis is a chronic autoimmune disease that primarily affects synovial joints, leading to synovial inflammation and joint damage. Timely and effective treatment is crucial for disease control, but misdiagnosis or delayed treatment often results in worsened condition and poor prognosis, significantly impacting patients' quality of life.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Lujun Chen, Hao Huang, Xiao Zheng, Yuan Li, Junjun Chen, Bo Tan, Yingting Liu, Runzi Sun, Bin Xu, Min Yang, Bin Li, Changping Wu, Binfeng Lu, Jingting Jiang
Summary: This study reveals the critical role of IL1 signaling in inhibiting Treg-mediated tumor immune suppression by modulating the interaction between Tregs and CAFs. These findings provide a theoretical basis for developing new anti-tumor immunotherapy strategies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Mahmoud S. Alghamri, Brandon L. McClellan, Margaret S. Hartlage, Santiago Haase, Syed Mohd Faisal, Rohit Thalla, Ali Dabaja, Kaushik Banerjee, Stephen V. Carney, Anzar A. Mujeeb, Michael R. Olin, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro
Summary: Gliomas, particularly glioblastomas, are highly aggressive and lethal cancers with unique molecular characteristics and genetic signatures. The interactions between tumor cells and immune cells in the tumor microenvironment play a critical role in glioma progression. Understanding the impact of inflammation and potential pharmacological interventions targeting neuro-inflammation are important for improving outcomes in glioma patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Vittoria Palmieri, Jana-Fabienne Ebel, Nhi Ngo Thi Phuong, Robert Klopfleisch, Vivian Pham Vu, Alexandra Adamczyk, Julia Zoller, Christian Riedel, Jan Buer, Philippe Krebs, Wiebke Hansen, Eva Pastille, Astrid M. Westendorf
Summary: IL-33 signaling pathway plays a critical role in regulating the immune response to enteric pathogens, affecting the colitis caused by microbial invasion. Deficiency of IL-33 can attenuate bacterial-induced colitis, while boosting its pathway can exacerbate the inflammatory response.
MUCOSAL IMMUNOLOGY
(2021)
Article
Oncology
Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, Hangyu Li
Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Article
Biochemistry & Molecular Biology
Yu-Ching Fan, Yu-Cin Fong, Chun-Tse Kuo, Chia-Wei Li, Wei-Yu Chen, Jian-Da Lin, Florian Buertin, Michael Linnebacher, Quoc Thang Bui, Kuan-Der Lee, Yuan-Chin Tsai
Summary: In this study, researchers found that IL-1Ra expression is elevated in human pancreatic ductal adenocarcinoma (PDA) and positively associated with its malignant progression. Further experiments demonstrated that IL-1Ra inhibits tumor growth in immune-competent mice by regulating immune cell activity. These findings suggest that IL-1Ra-targeted therapies could be a potential treatment for PDA.
CELL AND BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Liang Yan, Yanlian Tan, Guo Chen, Jun Fan, Jun Zhang
Summary: Metabolic reprogramming plays a critical role in cancer and immune cell function, particularly within the tumor microenvironment. Understanding the impact of metabolic reprogramming on both tumor and immune cells and their interaction is essential for effectively modulating the tumor immune microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Beatriz Subtil, Alessandra Cambi, Daniele V. F. Tauriello, I. Jolanda M. de Vries
Summary: Colorectal cancer is the third most common malignancy worldwide, with limited treatment effects for metastatic CRC patients and untreatable cancer metastasis being the main cause of most CRC deaths. Research shows that CRC creates an immunosuppressive tumor microenvironment to hinder immune clearance of tumors, with dysfunction of dendritic cells playing a crucial role in tumor growth and metastasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ombretta Melaiu, Gianluca Vanni, Ilaria Portarena, Chiara Adriana Pistolese, Lucia Anemona, Silvia Pomella, Roberto Bei, Oreste Claudio Buonomo, Mario Roselli, Alessandro Mauriello, Giovanni Barillari
Summary: Immune checkpoint inhibitors have limited clinical activity as monotherapy against breast cancer, and novel combinatorial strategies are being investigated to improve treatment response. The abnormal vasculature in breast cancer is associated with immune suppression and hampers drug delivery and immune cell trafficking. Combining immune checkpoint inhibitors with tumor vessel normalizing agents shows promise in enhancing antitumor immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Cedric Rossi, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, Don-Marc Franchini, Nadia Amara, Charlotte Syrykh, Pierre Bories, Lucie Oberic, Loic Ysebaert, Laurent Martin, Selim Ramla, Philippine Robert, Claire Tabouret-Viaud, Rene-Olivier Casasnovas, Jean-Jacques Fournie, Christine Bezombes, Camille Laurent
Summary: This study identified that baseline whole-body maximum standardized uptake (SUVmax) greater than 14.5 is associated with poorer progression-free survival (PFS) in follicular lymphoma (FL) patients. Immune T-cell infiltration and immune checkpoint expression were not associated with baseline PET metrics. However, FL samples with Ki-67 staining greater than or equal to 10% showed enrichment of cell cycle/DNA genes and significantly higher SUVmax values. High baseline SUVmax reflects FL tumor proliferation and can be used, along with Ki-67 proliferative index, to identify patients at risk of early relapse with rituximab chemotherapy.
Review
Oncology
Marcin Domagala, Chloe Laplagne, Edouard Leveque, Camille Laurent, Jean-Jacques Fournie, Eric Espinosa, Mary Poupot
Summary: The tumor is a complex system composed of various cells, among which myeloid cells play a crucial role in either eliminating cancer cells or promoting tumor growth. Different cellular interactions and soluble factors produced by these cells can influence tumor cell survival, proliferation, migration, and resistance. Interactions between malignant cells, stromal cells, and immune cells shape cancer progression, and targeting these cells has revolutionized cancer treatment.
Article
Medicine, Research & Experimental
Camille-Charlotte Balanca, Anna Salvioni, Clara-Maria Scarlata, Marie Michelas, Carlos Martinez-Gomez, Carlos Gomez-Roca, Victor Sarradin, Marie Tosolini, Carine Valle, Frederic Pont, Gwenael Ferron, Laurence Gladieff, Sebastien Vergez, Agnes Dupret-Bories, Eliane Mery, Philippe Rochaix, Jean-Jacques Fournie, Jean-Pierre Delord, Christel Devaud, Alejandra Martinez, Maha Ayyoub
Summary: Tumor antigen-specific CD4 T cells exhibit exhaustion in patients with head and neck, cervical, and ovarian cancer, characterized by high PD-1 and CD39 expression and low cytokine secretion despite functional presence. Terminal exhaustion of CD4 T cells is observed regardless of TIM-3 expression, suggesting divergence from CD8 T cell exhaustion. PD-1 blockade enhances CD4 T cell activation and promotes dendritic cell maturation, leading to improved tumor-specific CD8 T cell proliferation.
Review
Cell Biology
Nicolas Curdy, Olivia Lanvin, Sarah Cadot, Camille Laurent, Jean-Jacques Fournie, Don-Marc Franchini
Summary: Immune cell activation leads to transcriptional and translational programs, with stress granules playing a crucial role in controlling protein synthesis and ensuring accurate effector functions in immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Loic Ysebaert, Anne Quillet-Mary, Marie Tosolini, Frederic Pont, Camille Laurent, Jean-Jacques Fournie
Summary: High-definition transcriptomic studies using single-cell RNA sequencing have provided insights into cellular heterogeneity and functionality in solid tumors, offering valuable information for clinical response to immune checkpoint inhibitors. This technology also has the potential to uncover the intricate heterogeneity of ecosystems in different lymphoma entities.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Oncology
Mary Poupot
Article
Oncology
Fabien Gava, Carla Faria, Pauline Gravelle, Juan G. Valero, Celia Dobano-Lopez, Renaud Morin, Marine Norlund, Aurelie Gomes, Jean-Michel Lagarde, Cedric Rossi, Julie Bordenave, Laetitia Pieruccioni, Jacques Rouquette, Alba Matas-Cespedes, Jean-Jacques Fournie, Loic Ysebaert, Camille Laurent, Patricia Perez-Galan, Christine Bezombes
Summary: Follicular lymphoma is an incurable type of B cell lymphoproliferative disorder, accounting for a significant percentage of NHL cases. The development of a realistic 3D model offers a promising approach for testing new therapeutic targets.
Article
Immunology
Chloe Laplagne, Laetitia Ligat, Juliet Foote, Frederic Lopez, Jean-Jacques Fournie, Camille Laurent, Salvatore Valitutti, Mary Poupot
Summary: This study demonstrates that V gamma 9V delta 2 T cells can self-activate through exogenous PAgs independently, involving the molecules TCR, BTN3A1, and BTN2A1. Additionally, the involvement of ABCA-1 in the transfer of exogenous PAgs inside V gamma 9V delta 2 T cells was proposed, indicating a potential new mechanism for activation of these cytotoxic T cells against tumor cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yannick Degboe, Remy Poupot, Mary Poupot
Summary: Monocytes and macrophages play a crucial role in the immune system, detecting and eradicating danger signals while maintaining tissue homeostasis. Imbalance in their response can lead to pathological disorders, and repolarization of these unbalanced macrophages shows promise as a therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Marcin Domagala, Loic Ysebaert, Laetitia Ligat, Frederic Lopez, Jean-Jacques Fournie, Camille Laurent, Mary Poupot
Summary: In chronic lymphocytic leukemia, M2-like nurse-like cells (NLC) provide protection against apoptosis for leukemic cells through the release of IL-10, while M1-like NLC do not have this effect. The balance between IL-10 and TNF plays an important role in maintaining the protective phenotype of NLCs and the survival of CLL cells.
Article
Cell Biology
Nicolas Curdy, Olivia Lanvin, Juan-Pablo Cerapio, Frederic Pont, Marie Tosolini, Emeline Sarot, Carine Valle, Nathalie Saint-Laurent, Emeline Lhuillier, Camille Laurent, Jean-Jacques Fournie, Don-Marc Franchini
Summary: Stress granules (SGs) and processing bodies (PBs) are cytoplasmic assemblies that regulate mRNAs under environmental stress. This study characterizes the SGs and PBs in human T lymphocytes before and after stimulation using proteomic, transcriptomic, and immunofluorescence approaches. The findings reveal unexpected molecular and functional complementarity between SGs and PBs, although they maintain distinct spatial organizations and capacities to interact with mRNAs. This comprehensive characterization provides a valuable resource for future investigations on SGs and PBs in T lymphocytes.
Article
Oncology
Claudie Bosc, Estelle Saland, Aurelie Bousard, Noemie Gadaud, Marie Sabatier, Guillaume Cognet, Thomas Farge, Emeline Boet, Mathilde Gotanegre, Nesrine Aroua, Pierre-Luc Mouchel, Nathaniel Polley, Clement Larrue, Eleonore Kaphan, Muriel Picard, Ambrine Sahal, Latifa Jarrou, Marie Tosolini, Florian Rambow, Florence Cabon, Nathalie Nicot, Laura Poillet-Perez, Yujue Wang, Xiaoyang Su, Quentin Fovez, Jerome Kluza, Rafael Jose Arguello, Celine Mazzotti, Herve Avet-Loiseau, Francois Vergez, Jerome Tamburini, Jean-Jacques Fournie, Ing S. Tiong, Andrew H. Wei, Tony Kaoma, Jean-Christophe Marine, Christian Recher, Lucille Stuani, Carine Joffre, Jean-Emmanuel Sarry
Summary: Therapy resistance in AML is linked to high mitochondrial oxidative phosphorylation identified by MitoScore. Targeting mitochondrial metabolism can delay AML relapse, highlighting the central role of mitochondrial adaptation in AML therapy.
Review
Oncology
Margot Lavalee, Nicolas Curdy, Camille Laurent, Jean-Jacques Fournie, Don-Marc Franchini
Summary: Stress granules and P-bodies are membraneless cytoplasmic condensates composed of ribonucleoproteins, regulating RNA fate and playing crucial roles in cancer. Cancer cells utilize these granules to adapt to harsh environments, highlighting the importance of understanding their biology for clinical applications.