Article
Biochemistry & Molecular Biology
Jing Chen, Hong-Wei Sun, Yan-Yan Yang, Hai-Tian Chen, Xing-Juan Yu, Wen-Chao Wu, Yi-Tuo Xu, Li-Lian Jin, Xiao-Jun Wu, Jing Xu, Limin Zheng
Summary: In this study, it was found that reshaping MDSCs through autocrine IFN-alpha/beta and TNF-alpha from activated T cells is crucial for successful anti-PD-1 treatment in colorectal cancer. This offers a novel strategy for improving the response and efficacy of anticancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Immunology
Lifei Liang, Xiaoqing Xu, Jiawei Li, Cheng Yang
Summary: This review summarizes and discusses the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment, revealing the impact of miRNAs and MDSCs on tumor immune escape and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xinyu Ye, Xin Huang, Xing Fu, Xiao Zhang, Risheng Lin, Wen Zhang, Jian Zhang, Yi Lu
Summary: We discovered a cluster of tumor cells in prostate cancer bone metastases that expressed myeloid cell markers and showed significant changes in pathways related to immune regulation and tumor progression. Cell fusion between disseminated tumor cells and bone marrow cells may be the source of these myeloid-like tumor cells. These hybrid cells exhibited altered pathways related to cell adhesion and proliferation, increased proliferative and metastatic potential, resistance to docetaxel and ferroptosis, but sensitivity to radiotherapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Review
Cell Biology
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in ovarian cancer, with increased frequencies associated with poor prognosis. Depletion of MDSCs can significantly inhibit tumor growth and enhance the efficacy of existing anticancer therapies.
Article
Multidisciplinary Sciences
Ningshu Lin, Luyan Chen, Yunni Zhang, Yi Yang, Lei Zhang, Lei Chen, Peng Zhang, Huiming Su, Min Yin
Summary: KIF4A overexpression is associated with bladder cancer and activation of immunocytes. High expression of KIF4A is correlated with decreased CD8(+) tumor-infiltrating lymphocytes and worse prognosis in patients. KIF4A promotes tumor growth, especially in immune-competent mice.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Xinyu Cheng, Huilan Wang, Zhongyu Wang, Bo Zhu, Haixia Long
Summary: Tumor-associated myeloid cells (TAMCs) are crucial immune cell populations in the tumor microenvironment and have a significant impact on immune checkpoint blockade efficacy. Understanding the origin of TAMCs is essential for determining their functional diversity and developing cancer immunotherapy strategies. This review article provides an overview of recent research progress on evaluating the heterogeneity of TAMC origins. It also summarizes major therapeutic strategies targeting TAMCs with diverse sources, shedding light on their implications for cancer immunotherapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Paul R. Dominguez Gutierrez, Elizabeth P. Kwenda, William Donelan, Padraic O'Malley, Paul L. Crispen, Sergei Kusmartsev
Summary: This study identifies Hyal2-expressing tumor-associated myeloid cells of monocyte-macrophage lineage as contributors to hyaluronan degradation in bladder cancer tissue, leading to accumulation of inflammatory and proangiogenic low molecular weight hyaluronan fragments.
Review
Chemistry, Multidisciplinary
Xinghang Dai, Long Ren, Mengxi Liu, Hao Cai, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: MDSCs have been explored as an important immunotherapeutic target in cancer immunology, and nanomedicines have shown potential in reversing immunosuppressive tumors into immunoresponsive ones to enhance therapeutic efficacy.
Review
Cell Biology
Boris Guyot, Sylvain Lefort, Thibault Voeltzel, Eve-Isabelle Pecheur, Veronique Maguer-Satta
Summary: Understanding the mechanisms of cancer development is crucial for disease prevention and management. The microenvironment plays a significant role in regulating stem cell fate, and dysregulation of the BMP signaling pathway is associated with the emergence and expansion of cancer stem cells. This review focuses on the dysfunction of stem cells and their microenvironment in cancer, particularly in myeloid leukemia and breast cancers, through the hijacking of BMP signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. Mcdermott, Gordon J. Freeman, Kathleen M. Mahoney
Summary: It has been found that HHLA2 is expressed in primary kidney tumors, but its expression decreases during in vitro culture. A498 and 786-O ccRCC cell lines do not express HHLA2 in vitro, but HHLA2 expression is observed when grown as subcutaneous xenografts in NSG mice. Various cytokines and culture conditions failed to induce HHLA2 expression in A498 and 786-O tumor cell lines in vitro. IL-10 and BMP4, along with IL-1 beta and IL-6 to a lesser extent, modestly enhanced HHLA2 protein and mRNA expression in monocytes and dendritic cells.
Review
Nutrition & Dietetics
Philippe Icard, Mauro Loi, Zherui Wu, Antonin Ginguay, Hubert Lincet, Edouard Robin, Antoine Coquerel, Diana Berzan, Ludovic Fournel, Marco Alifano
Summary: The tumor microenvironment is complex and can be targeted by manipulating metabolic pathways, activating immune responses, and regulating host metabolic disorders to enhance cancer therapy. Future personalized therapies will require the development of new technologies and the combination of simple metabolic interventions, such as short periods of fasting or administration of specific compounds.
ADVANCES IN NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Yalei Wen, Yingjie Zhu, Caishi Zhang, Xiao Yang, Yuchen Gao, Mei Li, Hongyan Yang, Tongzheng Liu, Hui Tang
Summary: Chronic inflammation plays a crucial role in cancer development by shaping the inflammatory tumor microenvironment (TME) through interactions between cancer cells and various cell and non-cellular components. Pro-inflammatory cytokines and altered immune suppression contribute to immune escape and cancer progression. Immune checkpoint therapy (ICT) provides hope, but its efficacy is limited by the immunosuppressive TME. Ideal therapies involve targeting tumor cells, disrupting immunosuppressive TME, and reactivating anti-tumor T cells through ICT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Dhifaf Sarhan, Silke Eisinger, Fei He, Maria Bergsland, Catarina Pelicano, Caroline Driescher, Kajsa Westberg, Itziar Ibarlucea Benitez, Rawan Humoud, Giorgia Palano, Shuijie Li, Valentina Carannante, Jonas Muhr, Bjorn Onfelt, Susanne Schlisio, Jeffrey Ravetch, Rainer Heuchel, Matthias J. Lohr, Mikael C. Karlsson
Summary: Immunotherapy for cancer has revolutionized the treatment of previously lethal cancers, but its efficacy in pancreatic ductal adenocarcinoma (PDAC) has been disappointing. This study shows that the expression of scavenger receptor MARCO is associated with poor prognosis and a tumor phenotype that excludes lymphocytes. Targeting MARCO can remodel the tumor microenvironment and improve the efficiency of immunotherapy in PDAC patients.
Review
Biochemistry & Molecular Biology
Zengpanpan Ye, Xiaolin Ai, Linjie Zhao, Fan Fei, Ping Wang, Shengtao Zhou
Summary: Research suggests that targeting infiltrating myeloid cells in the tumor microenvironment may offer a novel direction for immunotherapy in improving the prognosis of patients with Glioblastoma (GBM). These myeloid cells play a crucial role in regulating GBM progression and affecting therapeutic efficacy.
Review
Immunology
Renata de Freitas Saito, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger Chammas
Summary: This review highlights the role of phosphatidylcholine metabolism in cancer therapy resistance, from intracellular processes to cellular communication within the tumor microenvironment, providing new insights for treating drug-resistant cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Cedric Rossi, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, Don-Marc Franchini, Nadia Amara, Charlotte Syrykh, Pierre Bories, Lucie Oberic, Loic Ysebaert, Laurent Martin, Selim Ramla, Philippine Robert, Claire Tabouret-Viaud, Rene-Olivier Casasnovas, Jean-Jacques Fournie, Christine Bezombes, Camille Laurent
Summary: This study identified that baseline whole-body maximum standardized uptake (SUVmax) greater than 14.5 is associated with poorer progression-free survival (PFS) in follicular lymphoma (FL) patients. Immune T-cell infiltration and immune checkpoint expression were not associated with baseline PET metrics. However, FL samples with Ki-67 staining greater than or equal to 10% showed enrichment of cell cycle/DNA genes and significantly higher SUVmax values. High baseline SUVmax reflects FL tumor proliferation and can be used, along with Ki-67 proliferative index, to identify patients at risk of early relapse with rituximab chemotherapy.
Article
Biology
Fanny Lafouresse, Romain Jugele, Sabina Mueller, Marine Doineau, Valerie Duplan-Eche, Eric Espinosa, Marie-Pierre Puissegur, Sebastien Gadat, Salvatore Valitutti
Summary: Research has found that during telophase, the lytic components in CD8(+) T cells are unevenly segregated. Mathematical modeling suggests that unequal inheritance of lytic molecules by daughter cells results from the random distribution of lytic granules on the two sides of the cleavage furrow. Furthermore, the level of lytic compartment in individual CTL dictates their killing capacity.
Article
Immunology
Chloe Laplagne, Laetitia Ligat, Juliet Foote, Frederic Lopez, Jean-Jacques Fournie, Camille Laurent, Salvatore Valitutti, Mary Poupot
Summary: This study demonstrates that V gamma 9V delta 2 T cells can self-activate through exogenous PAgs independently, involving the molecules TCR, BTN3A1, and BTN2A1. Additionally, the involvement of ABCA-1 in the transfer of exogenous PAgs inside V gamma 9V delta 2 T cells was proposed, indicating a potential new mechanism for activation of these cytotoxic T cells against tumor cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yannick Degboe, Remy Poupot, Mary Poupot
Summary: Monocytes and macrophages play a crucial role in the immune system, detecting and eradicating danger signals while maintaining tissue homeostasis. Imbalance in their response can lead to pathological disorders, and repolarization of these unbalanced macrophages shows promise as a therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Juan Pablo Cerapio, Marion Perrier, Frederic Pont, Marie Tosolini, Camille Laurent, Stephane Bertani, Jean-Jacques Fournie
Summary: The study characterized the differentiation of human gamma delta T lymphocytes in tumors and COVID-19 patients at the single-cell transcriptomic level. It found that tumor-infiltrating gamma delta T cells in certain cancer patients were more likely to recirculate and avoid exhaustion, while in COVID-19 patients, gamma delta T cells relocated to infected lung tissue displaying different differentiation, tissue residency, and exhaustion patterns.
Article
Oncology
Marcin Domagala, Loic Ysebaert, Laetitia Ligat, Frederic Lopez, Jean-Jacques Fournie, Camille Laurent, Mary Poupot
Summary: In chronic lymphocytic leukemia, M2-like nurse-like cells (NLC) provide protection against apoptosis for leukemic cells through the release of IL-10, while M1-like NLC do not have this effect. The balance between IL-10 and TNF plays an important role in maintaining the protective phenotype of NLCs and the survival of CLL cells.
Article
Oncology
Edouard Leveque, Axel Rouch, Charlotte Syrykh, Julien Mazieres, Laurent Brouchet, Salvatore Valitutti, Eric Espinosa, Fanny Lafouresse
Summary: TAMCs play a role in lung cancer and can be classified into two subsets based on CD103 expression. CD103(+) TAMCs are more mature, interact more with CD4(+) T cells, and are located closer to cancer cells. A high frequency of total TAMC is associated with better overall survival and progression-free survival.
Article
Chemistry, Multidisciplinary
Alba Ramos-Llorca, Lisse Decraecker, Valerie M. Y. Cacheux, Irena Zeiburlina, Michelle De Bruyn, Louise Battut, Carlos Moreno-Cinos, Davide Ceradini, Eric Espinosa, Gilles Dietrich, Maya Berg, Ingrid De Meester, Pieter van der Veken, Guy Boeckxstaens, Anne-Marie Lambeir, Alexandre Denadai-Souza, Koen Augustyns
Summary: Activity-based probes (ABP) are valuable tools for target identification and drug discovery. In this study, novel activity-based probes targeting serine proteases were synthesized and characterized. A library of probes with diverse chemical structures was developed, and their inhibitory potency and kinetic profile on a panel of serine proteases were determined. Surprisingly, reversible inhibitory mechanisms were observed for some of the high-affinity probes, challenging the conventional view of irreversible probes. This unexpected finding expands the potential applications of activity-based probes in proteomic studies and drug discovery.
FRONTIERS IN CHEMISTRY
(2023)
Letter
Allergy
Julien Stackowicz, Caitlin M. Gillis, Ophelie Godon, Bruno Iannascoli, Eva Conde, Edouard Leveque, William P. M. Worrall, Stephen J. Galli, Pierre Bruhns, Laurent L. Reber, Friederike Jonsson
Article
Cell Biology
Nicolas Curdy, Olivia Lanvin, Juan-Pablo Cerapio, Frederic Pont, Marie Tosolini, Emeline Sarot, Carine Valle, Nathalie Saint-Laurent, Emeline Lhuillier, Camille Laurent, Jean-Jacques Fournie, Don-Marc Franchini
Summary: Stress granules (SGs) and processing bodies (PBs) are cytoplasmic assemblies that regulate mRNAs under environmental stress. This study characterizes the SGs and PBs in human T lymphocytes before and after stimulation using proteomic, transcriptomic, and immunofluorescence approaches. The findings reveal unexpected molecular and functional complementarity between SGs and PBs, although they maintain distinct spatial organizations and capacities to interact with mRNAs. This comprehensive characterization provides a valuable resource for future investigations on SGs and PBs in T lymphocytes.
Review
Oncology
Margot Lavalee, Nicolas Curdy, Camille Laurent, Jean-Jacques Fournie, Don-Marc Franchini
Summary: Stress granules and P-bodies are membraneless cytoplasmic condensates composed of ribonucleoproteins, regulating RNA fate and playing crucial roles in cancer. Cancer cells utilize these granules to adapt to harsh environments, highlighting the importance of understanding their biology for clinical applications.