Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

Ivacaftor CFTR Potentiator Therapy is Efficient for Pancreatic Manifestations in Cystic Fibrosis

(2018) Ilias Kounis et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

CFTR structure

(2018) Isabelle Callebaut et al.   Journal of Cystic Fibrosis

Practical approach to the gastrointestinal manifestations of cystic fibrosis

(2018) Rishi Bolia et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis

(2018) Anita Balázs et al.   Frontiers in Physiology

Correction of Ductal CFTR Activity Rescues Acinar Cell and Pancreatic and Salivary Gland Functions in Mouse Models of Autoimmune Disease

(2017) Mei Zeng et al.   GASTROENTEROLOGY

Synergy of cAMP and calcium signaling pathways in CFTR regulation

(2017) Zoltan Bozoky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function

(2016) Anna Atlante et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

HCO3−Transport through Anoctamin/Transmembrane Protein ANO1/TMEM16A in Pancreatic Acinar Cells Regulates Luminal pH

(2016) Yanfeng Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+toxicity and mitochondrial damage in acute pancreatitis: translational overview

(2016) József Maléth et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Progress in therapies for cystic fibrosis

(2016) Kris De Boeck et al.   Lancet Respiratory Medicine

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells

(2015) Réginald Philippe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis

(2015) József Maléth et al.   GASTROENTEROLOGY

Breakdown of bioenergetics evoked by mitochondrial damage in acute pancreatitis: Mechanisms and consequences

(2015) József Maléth et al.   PANCREATOLOGY

Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis

(2015) Alessandro Rimessi et al.   Nature Communications

cAMP and Ca2+ signaling in secretory epithelia: Crosstalk and synergism

(2014) Malini Ahuja et al.   CELL CALCIUM

Calcium signaling in pancreatic ductal epithelial cells: An old friend and a nasty enemy

(2014) József Maléth et al.   CELL CALCIUM

Redox balance in Cystic Fibrosis

(2014) Assem G. Ziady et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

(2014) Jessica LaRusch et al.   PLoS Genetics

The Role of Pancreatic Ductal Secretion in Protection Against Acute Pancreatitis in Mice*

(2013) Petra Pallagi et al.   CRITICAL CARE MEDICINE

Irbit Mediates Synergy Between Ca 2+ and cAMP Signaling Pathways During Epithelial Transport in Mice

(2013) Seonghee Park et al.   GASTROENTEROLOGY

The Epidemiology of Pancreatitis and Pancreatic Cancer

(2013) Dhiraj Yadav et al.   GASTROENTEROLOGY

Role of Tyrosine Phosphorylation in the Muscarinic Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2013) Arnaud Billet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenylyl cyclase 6 mediates the action of cyclic AMP-dependent secretagogues in mouse pancreatic exocrine cells via protein kinase A pathway activation

(2013) Maria E. Sabbatini et al.   JOURNAL OF PHYSIOLOGY-LONDON

Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene

(2013) Patrick R Sosnay et al.   NATURE GENETICS

Intraductal acidosis in acute biliary pancreatitis

(2013) Tamás Takács et al.   PANCREATOLOGY

Mechanism and synergism in epithelial fluid and electrolyte secretion

(2013) Jeong Hee Hong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ethanol and its non-oxidative metabolites profoundly inhibit CFTR function in pancreatic epithelial cells which is prevented by ATP supplementation

(2013) L. Judák et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Contribution of  7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure

(2013) K. Maouche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cystic Fibrosis of Exocrine Pancreas

(2013) M. Wilschanski et al.   Cold Spring Harbor Perspectives in Medicine

CFTR activity and mitochondrial function

(2013) Angel Gabriel Valdivieso et al.   Redox Biology

Central role of mitochondrial injury in the pathogenesis of acute pancreatitis

(2012) J. Maléth et al.   Acta Physiologica

Organization of cAMP signalling microdomains for optimal regulation by Ca2+entry

(2012) Debbie Willoughby   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion

(2012) Min Goo Lee et al.   PHYSIOLOGICAL REVIEWS

The Mitochondrial Complex I Activity Is Reduced in Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function

(2012) Angel G. Valdivieso et al.   PLoS One

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

(2012) J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Pancreatic Stone Formation in Chronic Pancreatitis

(2012) Shigeru B. H. Ko et al.   Frontiers in Physiology

Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

(2011) Haouaria Balghi et al.   FASEB JOURNAL

Trypsin Reduces Pancreatic Ductal Bicarbonate Secretion by Inhibiting CFTR Cl− Channels and Luminal Anion Exchangers

(2011) Petra Pallagi et al.   GASTROENTEROLOGY

Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8

(2011) Ilse Delint-Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic pancreatitis

(2011) Joan M Braganza et al.   LANCET

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Increased Oxidative Stress Induces Apoptosis in Human Cystic Fibrosis Cells

(2011) Mathilde Rottner et al.   PLoS One

Defective Fluid Secretion from Submucosal Glands of Nasal Turbinates from CFTR-/- and CFTRΔF508/ΔF508 Pigs

(2011) Hyung-Ju Cho et al.   PLoS One

CFTR and Ca2+ signaling in cystic fibrosis

(2011) Fabrice Antigny   Frontiers in Pharmacology

Inhibition of acinar apoptosis occurs during acute pancreatitis in the human homologue ΔF508 cystic fibrosis mouse

(2010) Matthew J. DiMagno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Transient Receptor Potential Canonical Channel 6 Links Ca2+Mishandling to Cystic Fibrosis Transmembrane Conductance Regulator Channel Dysfunction in Cystic Fibrosis

(2010) Fabrice Antigny et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl−]i and Its Role in Pancreatic Bicarbonate Secretion

(2010) Hyun Woo Park et al.   GASTROENTEROLOGY

Corticosteroids Correct Aberrant CFTR Localization in the Duct and Regenerate Acinar Cells in Autoimmune Pancreatitis

(2010) Shigeru B.H. Ko et al.   GASTROENTEROLOGY

Protons Released During Pancreatic Acinar Cell Secretion Acidify the Lumen and Contribute to Pancreatitis in Mice

(2010) Natasha Behrendorff et al.   GASTROENTEROLOGY

Type of CFTR Mutation Determines Risk of Pancreatitis in Patients With Cystic Fibrosis

(2010) Chee Y. Ooi et al.   GASTROENTEROLOGY

Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells

(2010) J. Maleth et al.   GUT

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

(2010) Xingshen Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs

(2010) Nam Soo Joo et al.   JOURNAL OF CLINICAL INVESTIGATION

CFTR-Adenylyl Cyclase I Association Responsible for UTP Activation of CFTR in Well-Differentiated Primary Human Bronchial Cell Cultures

(2010) Wan Namkung et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases

(2010) M. L. Halls et al.   Cold Spring Harbor Perspectives in Biology

Effect of Initiating a Multidisciplinary Care Clinic on Access and Time to Treatment in Patients With Pancreatic Adenocarcinoma

(2010) Timothy B. Gardner et al.   Journal of Oncology Practice

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells

(2009) Fabrice Antigny et al.   MITOCHONDRION

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial injury in pancreatitis

(2008) R MUKHERJEE et al.   CELL CALCIUM

Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig

(2008) V Venglovecz et al.   GUT

A fire inside: current concepts in chronic pancreatitis

(2008) S. J. N. Tattersall et al.   INTERNAL MEDICINE JOURNAL

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR

(2007) Fabrice Antigny et al.   CELL CALCIUM