Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy

Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects

(2018) Haroon Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana

(2018) Muhammad Ovais et al.   BMC Complementary and Alternative Medicine

In vitro antioxidant and cholinesterase inhibitory activities of Elatostema papillosum leaves and correlation with their phytochemical profiles: a study relevant to the treatment of Alzheimer’s disease

(2018) A. S. M. Ali Reza et al.   BMC Complementary and Alternative Medicine

Phytochemical profiling and in vitro screening for anticholinesterase, antioxidant, antiglucosidase and neuroprotective effect of three traditional medicinal plants for Alzheimer’s Disease and Diabetes Mellitus dual therapy

(2018) Mohan Penumala et al.   BMC Complementary and Alternative Medicine

Methods To Measure the Antioxidant Activity of Phytochemicals and Plant Extracts

(2018) Riccardo Amorati et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease

(2018) Atish Kumar Sahoo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Epidemiological and Economic Burden of Alzheimer's Disease: A Systematic Literature Review of Data across Europe and the United States of America

(2018) Claire Takizawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Discontinuation, Efficacy, and Safety of Cholinesterase Inhibitors for Alzheimer’s Disease: a Meta-Analysis and Meta-Regression of 43 Randomized Clinical Trials Enrolling 16 106 Patients

(2017) Lídia Blanco-Silvente et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Antioxidant and acetylcholinesterase inhibitory activities in vitro of different fraction of Huperzia squarrosa (Forst.) Trevis extract and attenuation of scopolamine-induced cognitive impairment in mice

(2017) Bui Thanh Tung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea

(2017) Lucky Legbosi Nwidu et al.   PHARMACEUTICAL BIOLOGY

Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants

(2017) Muhammad Ayaz et al.   Frontiers in Aging Neuroscience

In Vitro Screening of Three Indian Medicinal Plants for Their Phytochemicals, Anticholinesterase, Antiglucosidase, Antioxidant, and Neuroprotective Effects

(2017) Mohan Penumala et al.   Biomed Research International

Synaptic pathology: A shared mechanism in neurological disease

(2016) Christopher M. Henstridge et al.   AGEING RESEARCH REVIEWS

Chemical composition, antioxidant and anticholinesterase potentials of essential oil of Rumex hastatus D. Don collected from the North West of Pakistan

(2016) Sajjad Ahmad et al.   BMC Complementary and Alternative Medicine

The Prevalence and Incidence of Dementia Due to Alzheimer’s Disease: a Systematic Review and Meta-Analysis

(2016) Kirsten M. Fiest et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research

(2016) U. Damar et al.   Expert Review of Neurotherapeutics

Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases

(2016) Hyun Ah Jung et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phytochemical and ethnomedicinal study of Huperzia species used in the traditional medicine of Saraguros in Southern Ecuador; AChE and MAO inhibitory activity

(2016) Chabaco Armijos et al.   JOURNAL OF ETHNOPHARMACOLOGY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Berberis Vulgarisand Berberine: An Update Review

(2016) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research

(2016) U. Damar et al.   Expert Review of Neurotherapeutics

Anti-diabetic and anti-Alzheimer’s disease activities of Angelica decursiva

(2015) Md. Yousof Ali et al.   ARCHIVES OF PHARMACAL RESEARCH

JapaneseHuperzia serrataextract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice

(2015) Takuya Ohba et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Chemical and Molecular Aspects on Interactions of Galanthamine and Its Derivatives with Cholinesterases

(2015) Hayrettin Gulcan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions

(2015) Sandrine Andrieu et al.   LANCET NEUROLOGY

Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: A comparative study

(2015) Natalie Cortes et al.   LIFE SCIENCES

Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: A Preliminary anti- Alzheimer’s study

(2015) Muhammad Ayaz et al.   Lipids in Health and Disease

BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos

(2014) Hyun Ah Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L

(2014) Muhammad Ayaz et al.   BMC Complementary and Alternative Medicine

Natural Products as Sources of New Lead Compounds for the Treatment of Alzheimer’s Disease

(2014) Ling Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects ofPersicaria hydropiper(L.) Delarbre

(2014) A. K. M. Moyeenul Huq et al.   Evidence-based Complementary and Alternative Medicine

Volatile Profiling of Aromatic Traditional Medicinal Plant, Polygonum minus in Different Tissues and Its Biological Activities

(2014) Rafidah Ahmad et al.   MOLECULES

Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?

(2014) Zhong Ming Qian et al.   Frontiers in Aging Neuroscience

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of alzheimer disease

(2013) Shereen K Ali et al.   BMC Complementary and Alternative Medicine

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

(2013) Ana Murray et al.   Current Neuropharmacology

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Isolation, characterization and acetylcholinesterase inhibitory activity of alkaloids from roots of Stemona sessilifolia

(2013) Dong-Hai Lai et al.   FITOTERAPIA

Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: Approaches to neurodegenerative disorders

(2013) Federico Ferreres et al.   FOOD AND CHEMICAL TOXICOLOGY

Berberis aetnensisandB. libanotica: a comparative study on the chemical composition, inhibitory effect on key enzymes linked to Alzheimer's disease and antioxidant activity

(2013) Marco Bonesi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam

(2013) Yongxin Zhao et al.   MOLECULES

Metabolite profiling driven analysis ofSalsolaspecies and their anti-acetylcholinesterase potential

(2013) Dalia M. Rasheed et al.   NATURAL PRODUCT RESEARCH

Phenolic composition, antioxidant and anti-acetylcholinesterase activities of the TunisianScabiosa arenaria

(2013) Malek Besbes Hlila et al.   PHARMACEUTICAL BIOLOGY

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

(2013) R. Tarawneh et al.   Cold Spring Harbor Perspectives in Medicine

The progress in the cholinesterase quantification methods

(2012) Ondrej Holas et al.   Expert Opinion on Drug Discovery

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease

(2011) Preet Anand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Huperzine A as Potential Treatment of Alzheimer's Disease: An Assessment on Chemistry, Pharmacology, and Clinical Studies

(2011) Giang T. Ha et al.   CHEMISTRY & BIODIVERSITY

Flavonoids as Acetylcholinesterase Inhibitors

(2011) I. Uriarte-Pueyo et al.   CURRENT MEDICINAL CHEMISTRY

In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer's Disease

(2011) Monica Rosa Loizzo et al.   Journal of Oleo Science

An Overview on Natural Cholinesterase Inhibitors - A Multi-Targeted Drug Class - and Their Mass Production

(2011) I. Erdogan Orhan et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

An aporphine alkaloid fromNelumbo nuciferaas an acetylcholinesterase inhibitor and the primary investigation for structure–activity correlations

(2011) Zhong-duo Yang et al.   NATURAL PRODUCT RESEARCH

A phase II trial of huperzine A in mild to moderate Alzheimer disease

(2011) M. S. Rafii et al.   NEUROLOGY

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

(2011) Laura A. Craig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Bioactive Isoquinoline Alkaloids fromCorydalis saxicola

(2011) Qiao-Qin Huang et al.   PLANTA MEDICA

In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa

(2011) EA Adewusi et al.   Asian Pacific Journal of Tropical Medicine

Acetylcholinesterase: From 3D structure to function

(2010) Hay Dvir et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

(2010) Elaine Monteiro Cardoso-Lopes et al.   MOLECULES

Salvia leriifolia Benth (Lamiaceae) extract demonstrates in vitro antioxidant properties and cholinesterase inhibitory activity

(2010) Monica R. Loizzo et al.   NUTRITION RESEARCH

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

(2009) Hyun Ah Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Assay conditions and validation of a new UV spectrophotometric method using microplates for the determination of polyphenol content

(2009) Iñigo Uriarte Pueyo et al.   FITOTERAPIA

Metabolite profile andin vitroactivities ofPhagnalon saxatile(L.) Cass. relevant to treatment of Alzheimer’s disease

(2009) Filomena Conforti et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission

(2009) David M. Pereira et al.   PHYTOMEDICINE

Cryptotanshinone, an Acetylcholinesterase Inhibitor fromSalvia miltiorrhiza, Ameliorates Scopolamine-Induced Amnesia in Morris Water Maze Task

(2009) Kelvin Wong et al.   PLANTA MEDICA

A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease

(2009) Shahin Akhondzadeh et al.   PSYCHOPHARMACOLOGY

Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.

(2008) Keyvan Dastmalchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum

(2008) Strahil Berkov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease

(2008) H.Q. Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cholinesterase inhibitory effects ofRhizophora lamarckii, Avicennia officinalis, Sesuvium portulacastrum and Suaeda monica:Mangroves inhabiting an Indian coastal area (Vellar Estuary)

(2008) Natarajan Suganthy et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY