Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

(2018) Mariana Temido-Ferreira et al.   MOLECULAR PSYCHIATRY

Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

(2018) António C. Silva et al.   NEUROBIOLOGY OF DISEASE

Astrocytic Adenosine A2A Receptors Control the Amyloid-β Peptide-Induced Decrease of Glutamate Uptake

(2018) Marco Matos et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Consumption Prevents Memory Impairment, Neuronal Damage, and Adenosine A2A Receptors Upregulation in the Hippocampus of a Rat Model of Sporadic Dementia

(2018) Janaína Espinosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Alterations of Brain Energy Metabolism in Type 2 Diabetic Goto-Kakizaki Rats Measured In Vivo by 13C Magnetic Resonance Spectroscopy

(2017) Freya-Merret Girault et al.   NEUROTOXICITY RESEARCH

Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

(2017) Roger J. Mullins et al.   Frontiers in Aging Neuroscience

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

(2016) Ana M. Fernandez et al.   DIABETES

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

A2A Adenosine Receptor Antagonism Reverts the Blood-Brain Barrier Dysfunction Induced by Sleep Restriction

(2016) Gabriela Hurtado-Alvarado et al.   PLoS One

Impact of diabetes on cognitive function and brain structure

(2015) Amir Moheet et al.   Annals of the New York Academy of Sciences

Adenosine A2Areceptors are necessary and sufficient to trigger memory impairment in adult mice

(2015) N Pagnussat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

(2015) Maria H. Madeira et al.   Journal of Neuroinflammation

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

(2015) P Li et al.   MOLECULAR PSYCHIATRY

Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a

(2015) Tsvetan Serchov et al.   NEURON

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

(2015) João M N. Duarte   Aging and Disease

The paradox of neuronal insulin action and resistance in the development of aging-associated diseases

(2014) Sophie M. Steculorum et al.   Alzheimers & Dementia

The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism

(2014) Pedro Cisternas et al.   JOURNAL OF NEUROCHEMISTRY

Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity

(2012) Maria P. Guarino et al.   AGE

Characterization of cerebral glucose dynamics in vivo with a four-state conformational model of transport at the blood-brain barrier

(2012) João M. N. Duarte et al.   JOURNAL OF NEUROCHEMISTRY

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice

(2012) João M. N. Duarte et al.   PLoS One

Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats

(2011) Silvia V. Conde et al.   BRITISH JOURNAL OF NUTRITION

Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing

(2011) Ana R. Costenla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice

(2011) C. Florian et al.   JOURNAL OF NEUROSCIENCE

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

(2010) J.M. Gaspar et al.   NEUROSCIENCE

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

(2009) João M. N. Duarte et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin

(2009) Albert Salehi et al.   LIFE SCIENCES

Adenosine A2Areceptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

(2008) Liqun Yu et al.   ANNALS OF NEUROLOGY

Modulation of insulin release by adenosine A1receptor agonists and antagonists in INS-1 cells: The possible contribution of86Rb+efflux and45Ca2+uptake

(2008) M. Töpfer et al.   CELL BIOCHEMISTRY AND FUNCTION

Purinergic receptor activation inhibits osmotic glial cell swelling in the diabetic rat retina

(2008) Antje Wurm et al.   EXPERIMENTAL EYE RESEARCH

Modification upon aging of the density of presynaptic modulation systems in the hippocampus

(2008) Paula M. Canas et al.   NEUROBIOLOGY OF AGING

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies

(2007) Reinaldo Naoto Takahashi   Frontiers in Bioscience-Landmark