Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome rats via PI3K/Akt pathways

Aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. (Apocynaceae) palliates hyperglycemia, insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome in rats

(2017) T.O. Ajiboye et al.   JOURNAL OF ETHNOPHARMACOLOGY

Betulinic acid protects against N-nitrosodimethylamine-induced redox imbalance in testes of rats

(2017) Gbadebo E. Adeleke et al.   REDOX REPORT

Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats

(2017) Oluwayemisi B. Ibitoye et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

(2016) Filomena S. G. Silva et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dioscoreophyllum cumminsii (Stapf) Diels leaves halt high-fructose induced metabolic syndrome: Hyperglycemia, insulin resistance, inflammation and oxidative stress

(2016) T.O. Ajiboye et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gallic acid ameliorates hyperglycemia and improves hepatic carbohydrate metabolism in rats fed a high-fructose diet

(2016) Da-Wei Huang et al.   NUTRITION RESEARCH

Targeting inflammation in metabolic syndrome

(2016) Francine K. Welty et al.   Translational Research

Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway

(2015) Peng Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Comparative effects of Aliskiren and Telmisartan in high fructose diet-induced metabolic syndrome in rats

(2015) Esraa M. Rabie et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hibiscus sabdariffacalyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats

(2015) Taofeek O Ajiboye et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Sucrose, fructose, glucose, and their link to metabolic syndrome and cancer

(2015) Undurti N. Das   NUTRITION

Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview

(2014) Dorina Gheorgheosu et al.   Anti-Cancer Agents in Medicinal Chemistry

Adiponectin Resistance and Proinflammatory Changes in the Visceral Adipose Tissue Induced by Fructose Consumption via Ketohexokinase-Dependent Pathway

(2014) George Marek et al.   DIABETES

Levocetirizine ameliorates high fructose diet-induced insulin resistance, vascular dysfunction and hepatic steatosis in rats

(2014) Noha M. Shawky et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat

(2014) Prem Prakash et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia

(2014) José Fernando Oliveira Costa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

(2014) Richard Mackenzie et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway

(2013) Hai Yan Quan et al.   BIOCHEMICAL PHARMACOLOGY

Tissue-specific regulation of inflammation by macrophage migration inhibitory factor and glucocorticoids in fructose-fed Wistar rats

(2013) Nataša Veličković et al.   BRITISH JOURNAL OF NUTRITION

Diphenyl diselenide supplementation reduces biochemical alterations associated with oxidative stress in rats fed with fructose and hydrochlorothiazide

(2013) Marinei Cristina Pereira Ribeiro et al.   CHEMICO-BIOLOGICAL INTERACTIONS

New Tools for Weight-Loss Therapy Enable a More Robust Medical Model for Obesity Treatment: Rationale for a Complications-Centric Approach

(2013) W. Garvey   Endocrine Practice

Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Pparα)

(2013) Li-juan Shi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation

(2013) He-Fang Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Betulinic acid and 1,25(OH)2 vitamin D3 share intracellular signal transduction in glucose homeostasis in soleus muscle

(2013) Allisson Jhonatan Gomes Castro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf-2

(2013) Taofeek O. Ajiboye et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice

(2013) Xiaofang Liu et al.   Lipids in Health and Disease

Diet patterns, adipokines, and metabolism: Where are we and what is next?

(2013) Byung-Joon Ko et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Today's and yesterday's of pathophysiology: Biochemistry of metabolic syndrome and animal models

(2013) Suleyman Aydin et al.   NUTRITION

Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats

(2013) Feng-Ching Hsieh et al.   Nutrition & Metabolism

Preventive effect of sesame seed cake on hyperglycemia and obesity against high fructose-diet induced Type 2 diabetes in rats

(2012) Papiya Bigoniya et al.   FOOD CHEMISTRY

Caffeine attenuates metabolic syndrome in diet-induced obese rats

(2012) Sunil K. Panchal et al.   NUTRITION

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Inflammation, Oxidative Stress, and Obesity

(2011) Alba Fernández-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Betulinic Acid has an Inhibitory Effect on Pancreatic Lipase and Induces Adipocyte Lipolysis

(2011) Junghyun Kim et al.   PHYTOTHERAPY RESEARCH

The metabolic syndrome

(2010) Robert H Eckel et al.   LANCET

Metabolic Syndrome: Comparison of the Two Commonly Used Animal Models

(2008) M. Oron-Herman et al.   AMERICAN JOURNAL OF HYPERTENSION

Betulinic Acid for Cancer Treatment and Prevention

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prevention of steatohepatitis by pioglitazone: Implication of adiponectin-dependent inhibition of SREBP-1c and inflammation

(2008) Alain Da Silva Morais et al.   JOURNAL OF HEPATOLOGY