Review
Cell Biology
Daniko P. Sindhunata, A. Stijn Meijnikman, Victor E. A. Gerdes, Max Nieuwdorp
Summary: The role of the intestinal microbiota in metabolic diseases has been recognized in recent decades. Diet is one of the major factors influencing the composition and function of the intestinal microbiota. The increased intake of dietary sugars, especially fructose, has been considered as a major risk factor for obesity and metabolic disturbances.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi
Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Richard J. Johnson, Dean R. Tolan, Dale Bredesen, Maria Nagel, Laura G. Sanchez-Lozada, Mehdi Fini, Scott Burtis, Miguel A. Lanaspa, David Perlmutter
Summary: Fructose metabolism activates a survival mechanism that helps preserve glucose supply for the brain in times of scarcity, but prolonged engagement of this mechanism may contribute to the development of Alzheimer's disease. Diets high in sugar, high glycemic carbohydrates, and salt can activate this pathway. Further studies are needed to understand the role of fructose metabolism and its metabolite, uric acid, in Alzheimer's disease, and dietary and pharmacologic trials should be conducted to explore potential benefits in the prevention, management, or treatment of this disease.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Article
Pharmacology & Pharmacy
Gehan Hussein Heeba, Esraa Mohamed Rabie, Mekky Mohamed Abuzeid, Amany Abdelrehim Bekhit, Mohamed Montaser Khalifa
Summary: This study showed that administration of morin significantly reduced elevated systolic blood pressure and reversed altered levels of metabolic parameters in fructose diet rats. Morin treatment also decreased liver index, serum liver enzyme activities, and fat/muscle ratio, while relatively up-regulating GLUT2 expression and down-regulating NF-kappa B, TNF-alpha, and TGF-beta expressions in hepatic tissues. The results suggest that morin has beneficial effects against metabolic disorders through antioxidant, anti-inflammatory, and anti-fibrotic mechanisms.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Francois-Guillaume Debray, Kevin Seyssel, Marjorie Fadeur, Luc Tappy, Nicolas Paquot, Christel Tran
Summary: The study showed that overfeeding on fructose can lead to increased uric acid and insulin resistance, with a more significant impact on carriers of hereditary fructose intolerance.
CLINICAL NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Michelle Moughaizel, Elie Dagher, Nora Bouhsina, Valerie Lalanne, Chantal Thorin, Jean-Claude Desfontis, M. Yassine Mallem
Summary: The study investigates the therapeutic potential of mirabegron for the treatment of metabolic syndrome. The long-term treatment with mirabegron in WHHL rabbits prevented the increase in TG levels and the establishment of insulin resistance, while enhancing cardiac function. However, it also aggravated atherosclerosis development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Health Care Sciences & Services
George E. Zakynthinos, Vasiliki Tsolaki, Evangelos Oikonomou, Manolis Vavouranakis, Gerasimos Siasos, Epaminondas Zakynthinos
Summary: Metabolic syndrome and atrial fibrillation are closely related, as metabolic syndrome affects the left atrium in multiple ways, leading to the progression of atrial fibrillation. A holistic treatment approach can improve patient outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Jose Ignacio Ramirez-Manent, Andres Martinez Jover, Caroline Silveira Martinez, Pilar Tomas-Gil, Pau Marti-Lliteras, Angel Arturo Lopez-Gonzalez
Summary: Metabolic syndrome (Met-S) is a significant health problem associated with insulin resistance (IR). This study aims to assess the relationship between different insulin resistance risk scales and Met-S and identify the components of Met-S that contribute most to IR. The results demonstrate that insulin resistance risk scales can accurately classify individuals with Met-S, particularly when using the International Diabetes Federation (IDF) criteria, and waist circumference is the key factor associated with both IR and Met-S.
Article
Multidisciplinary Sciences
Laetitia Coassolo, Tianyun Liu, Yunshin Jung, Nikki P. Taylor, Meng Zhao, Gregory W. Charville, Silas Boye Nissen, Hannele Yki-Jarvinen, Russ B. Altman, Katrin J. Svensson
Summary: Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disease with unclear molecular mechanisms. By analyzing single-cell RNA sequencing data, this study identifies previously unknown clusters of hepatocytes with distinct lipid signatures and uncovers high constitutive androstane receptor (CAR) expression as a novel driver of NAFLD. The study further reveals the functional modules associated with CAR and demonstrates the correlation between CAR expression and steatohepatitis in human livers. These findings provide valuable insights into the cellular differences in lipid signatures and the underlying mechanisms of hepatic steatosis.
Review
Immunology
Yan Hao, Ya-juan Zhu, Song Zou, Pei Zhou, Ya-wen Hu, Qi-xiang Zhao, Lin-na Gu, Hao-zhou Zhang, Zhen Wang, Jiong Li
Summary: The association between psoriasis and metabolic syndrome involves various mechanisms including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels, and gut microbiota dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Marietta Rottenkolber, Christina Gar, Cornelia Then, Lorena Wanger, Vanessa Sacco, Friederike Banning, Anne L. Potzel, Stefanie Kern-Matschilles, Claudia Nevinny-Stickel-Hinzpeter, Harald Grallert, Nina Hesse, Jochen Seissler, Andreas Lechner
Summary: This study re-evaluated the prevailing hypothesis that metabolic syndrome components are central to all cases of T2DM. Results showed that a significant proportion of T2DM cases did not display any components of metabolic syndrome, indicating the existence of a second, unrelated pathophysiology.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Mekky M. Abouzied, Heba M. Eltahir, Ashraf Taye, Mahran S. Abdelrahman
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2016)
Article
Pharmacology & Pharmacy
Marwa A. M. Ali, Gehan H. Heeba, Azza A. K. El-Sheikh
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2017)
Article
Chemistry, Analytical
Brooke E. Roman, Dana Driksna, Mohamed M. Abouzied, Frank Klein, Jennifer Rice
JOURNAL OF AOAC INTERNATIONAL
(2017)
Article
Cardiac & Cardiovascular Systems
Asmaa I. Matouk, Ashraf Taye, Mohamed A. El-Moselhy, Gehan H. Heeba, Abdel A. Abdel-Rahman
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2017)
Article
Pharmacology & Pharmacy
Mekky M. Abouzied, Maiiada H. Nazmy, Randa M. Mohamed, Michael A. Fawzy, Heba M. Eltahir
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Asmaa I. Matouk, Ashraf Taye, Mohamed A. El-Moselhy, Gehan H. Heeba, Abdel A. Abdel-Rahman
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Rania G. Abdel-latif, Gehan H. Heeba, Ashraf Taye, Mohamed M. A. Khalifa
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Chemistry, Analytical
Ewa Slotwinski, Dave Almy, Ryan Viator, Mohamed Abouzied, Frank Klein, Jennifer Rice
JOURNAL OF AOAC INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Hanan Mohamed Elwy, Chandraprabha Murali, Raafat El-Awady, Amr Amin
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Heba M. Eltahir, Ghadi Alamri, Asmaa Alamri, Asmaa Aloufi, Maiiada Nazmy, Saleh Bahashwan, Hossein M. Elbadawy, Yaser M. Alahmadi, Mekky M. Abouzied
ACTA BIOCHIMICA POLONICA
(2020)
Article
Medicine, Research & Experimental
Mekky M. Abouzied, Shaymaa M. Mahmoud, Ahmed Wahid, Amr E. Ahmed, Ahmed M. Okasha, Hanan A. Soliman, Sultan S. Al Thagfan, Eman Z. Attia
JOURNAL OF APPLIED BIOMEDICINE
(2020)
Article
Virology
Hossein M. Elbadawy, Mohi I. Mohammed Abdul, Naif Aljuhani, Adriana Vitiello, Francesco Ciccarese, Mohamed A. Shaker, Heba M. Eltahir, Giorgio Pala, Veronica Di Antonio, Hanieh Ghassabian, Claudia Del Vecchio, Cristiano Salata, Elisa Franchin, Eleonora Ponterio, Saleh Bahashwan, Khaled Thabet, Mekky M. Abouzied, Ahmed M. Shehata, Cristina Parolin, Arianna Calistri, Gualtiero Alvisi
Article
Virology
Hossein M. Elbadawy, Amin Khattab, Ali Alalawi, Fahad Dakilallah Aljohani, Hamza Sundogji, Ameira S. Mahmoud, Meky Abouzied, Heba M. Eltahir, Ziab Alahmadey, Saleh Bahashwan, Bandar A. Suliman
Summary: Studies have confirmed that surfaces and objects in hospitals, isolation rooms, outpatient clinics, and public facilities can be contaminated with SARS-CoV-2. Attention is needed to decontaminate frequently touched surfaces in healthcare facilities and public spaces to reduce the risk of transmission.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Nabil Mohie Abdel-Hamid, Moustafa Fathy, Chika Koike, Toshiko Yoshida, Motonori Okabe, Kaixuan Zho, Mekky Abouzied, Toshio Nikaido
Summary: The study revealed that CD44(+)CD24(+) HeLa cells exhibit characteristics of CSCs, including the ability to form spheres, tumorigenicity, stemness genes, and higher resistance to cisplatin and X-ray. This suggests that targeting these cells may lead to the screening of new anti-cancer therapies.
CANCER INVESTIGATION
(2021)
Article
Immunology
Heba M. Eltahir, Naif Aljuhani, Sara A. Alsubhi, Ghada M. Alahmadi, Hossein M. Elbadawy, Mekky M. Abouzied
EUROPEAN JOURNAL OF INFLAMMATION
(2019)