Article
Multidisciplinary Sciences
Nathalie Coutry, Julie Nguyen, Salima Soualhi, Francois Gerbe, Victoria Meslier, Valerie Dardalhon, Mathieu Almeida, Benoit Quinquis, Florence Thirion, Fabien Herbert, Imene Gasmi, Ali Lamrani, Alicia Giordano, Pierre Cesses, Laure Garnier, Steeve Thirard, Denis Greuet, Chantal Cazevieille, Florence Bernex, Christelle Bressuire, Douglas Winton, Ichiro Matsumoto, Herve M. Naomi And, Naomi Taylor, Philippe Jay
Summary: Imbalance of gut microbiota is associated with pathological conditions. We propose a three-step mechanism for dysbiosis initiation, involving Paneth cell dysfunction, activation of epithelial tuft cells, and chronic inflammation. Paneth cells play an essential role in maintaining a balanced microbiota and preventing dysbiosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Chemistry, Multidisciplinary
Thifhelimbilu Luvhengo, Susan Mabasa, Edith Molepo, Itumeleng Taunyane, Sechaba Thabo Palweni
Summary: Around 500 million adults worldwide are diagnosed with diabetes mellitus, with an increasing incidence rate. Majority of type 2 diabetes mellitus cases are associated with dysbiosis of the gut microbiota, chronic systemic inflammation, mitochondrial dysfunction, and beta-cell destruction in the pancreas. Paneth cells, located throughout the small intestine, play a crucial role in its innate immunity. Deficient Paneth cell function increases the susceptibility to gastrointestinal and extra-gastrointestinal diseases, including inflammatory bowel disease. This review discusses the roles of Paneth cells in the small intestine's innate immunity, the relationship between dysbiosis and Paneth cell dysfunction, and the impact of dysbiosis on the development of diabetes mellitus. The manuscript also examines current strategies aimed at reversing dysbiosis and its consequences.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Christopher J. Anderson, Christopher B. Medina, Brady J. Barron, Laura Karvelyte, Tania Love Aaes, Irina Lambertz, Justin S. A. Perry, Parul Mehrotra, Amanda Goncalves, Kelly Lemeire, Gillian Blancke, Vanessa Andries, Farzaneh Ghazavi, Arne Martens, Geert van Loo, Lars Vereecke, Peter Vandenabeele, Kodi S. Ravichandran
Summary: The study demonstrates how nutrients released from apoptotic cells can promote the growth of Enterobacteriaceae and highlights the role of pyruvate formate-lyase-encoding pflB gene in bacterial colonization in various contexts. These findings provide new insights into host-pathogen interactions and have implications for gut inflammation and chemotherapy treatment.
Review
Endocrinology & Metabolism
Carlotta De Filippo, Alessia Costa, Maria Vittoria Becagli, Mariela Mejia Monroy, Gustavo Provensi, Maria Beatrice Passani
Summary: A vast literature suggests that the endocannabinoid system and related bioactive lipids play a role in physiological processes and pathological conditions. The gut paracannabinoid system affects gut physiology, while the intestinal microbiota is crucial in regulating the immune system. The interplay between microbiota and paracannabinoids appears as a potent regulatory system for gastrointestinal homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Li Guo, Peilun Xiao, Xiaoxia Zhang, Yang Yang, Miao Yang, Ting Wang, Haixia Lu, Hongyan Tian, Hao Wang, Juan Liu
Summary: This study demonstrated that dietary inulin modulated the gut microbiota and exerted anti-inflammatory effects, leading to improved aberrant behaviors and neuronal damage in mice with SCZ, suggesting a potential role for inulin intervention as a novel treatment strategy for SCZ.
Article
Biochemistry & Molecular Biology
Ming-zhi Zhu, Fang Zhou, Jian Ouyang, Qi-ye Wang, Yi-long Li, Jian-lin Wu, Jian-an Huang, Zhong-hua Liu
Summary: The combination of low-doses of EGCG and caffeine has been shown to exhibit synergistic anti-obesity effects equivalent to high-dose EGCG, and also has notable effects on gut microbiota and bile acid metabolism.
Review
Gastroenterology & Hepatology
Blaine Caslin, Kailey Mohler, Shreya Thiagarajan, Esther Melamed
Summary: Alcohol may have complex effects on autoimmune diseases, with potential pro-inflammatory and anti-inflammatory properties. These effects may be related to factors such as the dose, duration, type, cultural background, and sex of alcohol consumption.
Article
Multidisciplinary Sciences
Guanqun Li, Liwei Liu, Tianqi Lu, Yuhang Sui, Can Zhang, Yongwei Wang, Tao Zhang, Yu Xie, Peng Xiao, Zhongjie Zhao, Chundong Cheng, Jisheng Hu, Hongze Chen, Dongbo Xue, Hua Chen, Gang Wang, Rui Kong, Hongtao Tan, Xuewei Bai, Zhibo Li, Florencia McAllister, Le Li, Bei Sun
Summary: This study explores the association between gut microbiota dysbiosis and hypertriglyceridemic pancreatitis (HTGP). The researchers observe lower gut microbiota diversity and absence of beneficial bacteria in HTGP patients. Through a mouse model, they find that colonization of gut microbiota from HTGP patients leads to recruitment of neutrophils and increased formation of neutrophil extracellular traps (NETs), which exacerbates pancreatic injury and systemic inflammation. Furthermore, they discover that decreased abundance of Bacteroides uniformis in gut microbiota impairs taurine production and increases IL-17 release in the colon, triggering NETs formation. Bacteroides uniformis or taurine inhibits the activation of NF-kappa B and IL-17 signaling pathways in neutrophils, reducing NETs formation and alleviating pancreatic injury.
NATURE COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Bing-Nan Liu, Xiao-Tong Liu, Zi-Han Liang, Ji-Hui Wang
Summary: Obesity is a major global health issue affected by genetics and environment, with increasing evidence linking it to gut microbiota. Gut microbiota management has emerged as a new approach for obesity treatment, but the complex interactions among genetics, environment, microbiota, and obesity are still not well-understood. The review summarizes the characteristics of gut microbiota in obesity, the mechanisms linking gut microbiota to obesity, and the impact of genetic and environmental factors, providing insight into the complex relationship between obesity and microbiota, as well as proposing the future of gut microbiota-related obesity research.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Marc Schoeler, Sandrine Ellero-Simatos, Till Birkner, Jordi Mayneris-Perxachs, Lisa Olsson, Harald Brolin, Ulrike Loeber, Jamie D. Kraft, Arnaud Polizzi, Marian Marti-Navas, Josep Puig, Antonio Moschetta, Alexandra Montagner, Pierre Gourdy, Christophe Heymes, Herve Guillou, Valentina Tremaroli, Jose Manuel Fernandez-Real, Sofia K. Forslund, Remy Burcelin, Robert Caesar
Summary: The relationship between dietary lipids and gut microbiota has an impact on the development of liver steatosis. Low intake of saturated fatty acids is associated with increased microbial diversity in humans, while poorly absorbed dietary long-chain saturated fatty acids improve metabolism and steatosis in mice through a shift in bile acid profile.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Marcin Choroszy, Beata Sobieszczanska, Kamil Litwinowicz, Lukasz Laczmanski, Mateusz Chmielarz, Urszula Walczuk, Tomasz Roleder, Jadwiga Radziejewska, Magdalena Wawrzynska
Summary: This study investigated the role of gut dysbiosis in coronary arterial disease (CAD) development. The results showed that CAD patients exhibited gut dysbiosis, as well as elevated levels of bacterial metabolites LPS and indoxyl sulfate in their blood. Furthermore, LPS and indoxyl sulfate were found to have co-toxicity on endothelial cells and promote thrombogenicity. These findings suggest that increased intestinal permeability caused by gut dysbiosis may contribute to endothelial inflammation and atherosclerosis progression.
Article
Microbiology
Preeti Dinesh Virwani, Lin Cai, Patrick Ka Kit Yeung, Gordon Qian, Yingxian Chen, Lei Zhou, Jason Wing Hon Wong, Yu Wang, Joshua Wing Kei Ho, Kui Kai Lau, Pei-Yuan Qian, Sookja Kim Chung
Summary: Epac2(-/)(-) mice exhibit gut dysbiosis under physiological conditions, and WD feeding leads to gut microbiome imbalance in mice regardless of genotype; Epac1(-/)(-) mice show more severe inflammation and insulin resistance after WD feeding.
Article
Gastroenterology & Hepatology
Xiaomin Su, Mengli Jin, Chen Xu, Yunhuan Gao, Yazheng Yang, Houbao Qi, Qianjing Zhang, Xiaorong Yang, Wang Ya, Yuan Zhang, Rongcun Yang
Summary: This study reveals that FABP4 in the Paneth cells can downregulate the expression of defensins by degrading PPAR-gamma. This downregulation not only occurs in mice, but also in humans. Additionally, a high-fat diet induces an increase in FABP4 in Paneth cells, leading to a decrease in defensin expression. These findings are important for understanding the underlying factors of modern diseases.
Article
Environmental Sciences
Zhenguang Yan, Jinzhe Du, Tianxu Zhang, Qianhang Sun, Binbin Sun, Yan Zhang, Shuo Li
Summary: The study found that TCC had toxic effects on the gut of zebrafish, leading to inflammation and changes in gut microbial composition, as well as damage to gut tissue.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Jamie van Son, Laura L. Koekkoek, Susanne E. La Fleur, Mireille J. Serlie, Max Nieuwdorp
Summary: Obesity, a global epidemic, is associated with microbial dysbiosis. Research indicates that the gut microbiota and its metabolites have an impact on human brain and behavior. Future treatment strategies for obesity may target the gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)