Article
Biology
Shauni Doms, Hanna Fokt, Malte Christoph Ruehlemann, Cecilia J. Chung, Axel Kuenstner, Saleh M. Ibrahim, Andre Franke, Leslie M. Turner, John F. Baines
Summary: This study investigates the impact of host genetics on gut microbial traits using a powerful genetic mapping approach. The results reveal high heritability of mucosa-associated bacterial taxa and identify 428 genetic loci influencing these bacteria through genome-wide association mapping. Additionally, candidate genes associated with human diseases and immune function are identified.
Article
Gastroenterology & Hepatology
Yan Li, Haiting Sun, Yufen Huang, Anqi Yin, Linjuan Zhang, Jiao Han, Yixuan Lyu, Xiangzhao Xu, Yifang Zhai, Huan Sun, Ping Wang, Jinyang Zhao, Silong Sun, Hailong Dong, Feng Zhu, Qiang Wang, Luis Augusto Rohde, Xuefeng Xie, Xin Sun, Lize Xiong
Summary: Attention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous psychiatric disorder, and the gut microbial characteristics of patients may be associated with the development and symptomatic presentations of ADHD.
Article
Microbiology
Xingkun Jin, Haoyong Zhu, Yan Shi, Ziwei Chen, Yaohui Wang, Jian-Fang Gui, Zhe Zhao
Summary: Through gut microbiota profiling, we found that hybridization and cohabitation of pufferfish can significantly disturb the gut microbiota composition and function. These results enhance our understanding of the complex and dynamic assemblage of the fish holobiont from a microbial perspective and have practical implications for optimizing performance prediction and improving farmed fish production.
Review
Gastroenterology & Hepatology
Pierre Lapaquette, Jean-Baptiste Bizeau, Niyazi Acar, Marie-Agnes Bringer
Summary: A symbiotic relationship has been formed between gut microbiota and its host, with autophagy playing a crucial role in maintaining cell survival and homeostasis. Gut microbiota modulates host autophagy locally in the gut and peripheral organs, while autophagy also affects the gut microbiota. Targeting the gut microbiota to modulate host autophagy presents a future intervention for maintaining symbiosis and overall health.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Food Science & Technology
Chen Wang, Junying Bai, Xiaoyong Chen, Jiajia Song, Yu Zhang, Hongwei Wang, Huayi Suo
Summary: Host health and disease are affected by changes in intestinal flora. Strategies such as probiotics, prebiotics, diet, fecal microbiota transplantation, antibiotics, and phages can regulate the structure and abundance of microflora. Diets and prebiotics have reduced risk and high security, while phages have high specificity for targeted regulation. Individual variability in microflora and metabolic response should be considered, and future studies should use artificial intelligence and multi-omics to develop personalized intervention strategies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Review
Biochemistry & Molecular Biology
Salma Sultan, Walid Mottawea, JuDong Yeo, Riadh Hammami
Summary: Dysbiosis of gut microbiota has been linked to various health disorders over the past decade, but the detailed mechanism of this correlation remains unclear. Recently, microbiota-released extracellular vesicles (MEVs) have emerged as significant mediators in intercellular signaling, potentially playing an integral role in microbiota-host communications. MEVs are small membrane-bound vesicles that carry a wide range of biologically active compounds, facilitating the horizontal transfer of their cargo across intra- and intercellular space.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Meixia Li, Yeqing Wang, Ciliang Guo, Sheng Wang, Liangzhen Zheng, Yifan Bu, Kan Ding
Summary: A demonstration of cellulose degrading bacterium from human gut challenged the belief that humans cannot degrade cellulose. However, research on the molecular level of cellulose degradation by human gut microbiota is still incomplete. Using cellobiose as a model, we investigated the molecular mechanism behind cellulose degradation by key members of the human gut microbiota, such as Bacteroides ovatus (BO). Our results showed that a new polysaccharide utilization locus (PUL) from BO was involved in cellobiose capturing and degradation, and two new cellulases on the cell surface, BACOVA_02626 (GH5) and BACOVA_02630 (GH5), were responsible for cellobiose degradation into glucose. Studies on mice also revealed that cellobiose reshaped the gut microbiota composition and potentially modified bacterial metabolic functions. These findings provide further evidence of cellulose degradation by human gut microbes and contribute new insights to cellulose research.
Article
Microbiology
Jiandong Yang, Yun Zhong, Liqun Xu, Bo Zeng, Kang Lai, Mingxian Yang, Diyan Li, Ye Zhao, Mingwang Zhang, Debing Li
Summary: The study found that the gut microbiota of asexual hybridization queens bred through nutritional crossbreeding differs slightly from normally bred queens, with dominant genera being Brevundimonas, Bombella, and Lactobacillus, and more related to A. mellifera queens. Genetic background plays a more dominant role in shaping the gut microbiota of honeybee queens.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paola Cuomo, Rosanna Capparelli, Marco Alifano, Antonio Iannelli, Domenico Iannelli
Summary: Metabolites from gut microbiota are crucial for various functions in the body, such as immune system development, pathogen interception, and nutritional enrichment. Alteration of gut microbiota is connected to gastrointestinal infection, obesity, diabetes, inflammatory bowel disease, colorectal cancer, and lung cancer. Diet changes and antibiotics have a significant impact on gut microbiota. Further research is needed to understand the interaction between host genes, microbiota, and the environment, and longitudinal studies on patients undergoing therapy could provide valuable insights for improving treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ben A. Kappel, Lorenzo De Angelis, Andreas Puetz, Marta Ballanti, Rossella Menghini, Nikolaus Marx, Massimo Federici
Summary: There is a link between gut microbiota and host cholesterol metabolism, and changes in gut microbiota may contribute to hypercholesterolemia. Treatment with antibiotics can increase serum cholesterol levels and potentially impact cardiovascular disease.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Cheng Li
Summary: Human responses to the same diets vary due to complex diet-host-microbiota interactions. Recent advances show that quantifying this interaction could lead to personalized nutrition strategies for improving individual health. The gut microbiome, compared to host related factors, can be easily modulated by dietary exposures and plays a crucial role in human health. However, limitations in processing and analyzing 'big-data' on the human microbiome hinder the translation of diet-host-microbiota interactions into tools for personalized health improvement. This review aims to summarize recent advances in understanding diet-host-microbiota interactions to aid in the development of personalized nutrition strategies.
Review
Microbiology
Kunling Teng, Fuqing Huang, Yayong Liu, Yudong Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Gut microbes and their interactions with the host have an impact on human health and diseases. Bacteriocins, produced by gut commensals and food-originated bacteria, can inhibit pathogens and modulate gut microbiota. They are potential candidates for precision therapy of gut disorders. Lactic acid bacteria, including many probiotics, are the main producers of bacteriocins. Bacteriocin production is considered a probiotic trait that provides a competitive advantage to bacteria in colonizing the human gut and mediating interactions with the host ecosystem.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Microbiology
Pil Soo Kim, Na-Ri Shin, Jae-Bong Lee, Min-Soo Kim, Tae Woong Whon, Dong-Wook Hyun, Ji-Hyun Yun, Mi-Ja Jung, Joon Yong Kim, Jin-Woo Bae
Summary: This study comprehensively characterized gut bacterial communities in fish, revealing that the dominant phyla were Proteobacteria and Firmicutes. The gut microbiota in fish was more strongly influenced by host habitat than by host taxonomy or trophic level.
Article
Multidisciplinary Sciences
Anna S. Weiss, Lisa S. Niedermeier, Alexandra von Strempel, Anna G. Burrichter, Diana Ring, Chen Meng, Karin Kleigrewe, Chiara Lincetto, Johannes Huebner, Baerbel Stecher
Summary: By characterizing a synthetic gut bacterial community, the authors challenge the concept of universal keystone species in the gastrointestinal ecosystem, revealing a context dependency of keystone functions and bacterial interaction networks.
NATURE COMMUNICATIONS
(2023)
