Article
Biochemistry & Molecular Biology
Tao Yu, Tianhan Dong, Haniyeh Eyvani, Yuanzhang Fang, Xiyu Wang, Xinna Zhang, Xiongbin Lu
Summary: Metabolic reprogramming is a key factor in the competition between cancer cells and immune cells in the tumor microenvironment. Therapeutic strategies targeting the metabolic dependence of cancer cells can restore anti-tumor responses of T cells.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Wen Tian, Xiaoying Niu, Feifei Feng, Xin Wang, Jiaqiang Wang, Weitao Yao, Peng Zhang
Summary: Osteosarcoma, the most common malignant bone sarcoma in children, is hindered by chemotherapy drugs resistance. Exosomal miRNAs play an important role in the occurrence, development, and drug resistance of osteosarcoma. Exploration of exosome biogenesis and role of exosomal miRNAs provides new strategies and targets for understanding the pathogenesis of osteosarcoma and overcoming drug resistance. Engineering modification of exosomes enhances their targeting ability, making them more effective in delivering cargos to recipient cells. This review focuses on the mechanisms of exosomal miRNAs in osteosarcoma and their potential as tumor biomarkers, as well as recent advances in the clinical application of engineering exosomes to overcome chemotherapy resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Materials Science, Multidisciplinary
Charles Oluwaseun Adetunji, Olugbenga Samuel Michael, Shweta Rathee, Kshitij R. B. Singh, Olulope Olufemi Ajayi, Juliana Bunmi Adetunji, Ankur Ojha, Jay Singh, Ravindra Pratap Singh
Summary: Metabolic syndrome is a cluster of abnormalities that significantly increase the risk of developing type 2 diabetes and cardiovascular diseases. Despite limitations in current therapies, nanotechnology is emerging as a promising tool for managing metabolic disorders, offering targeted drug delivery and early disease detection benefits.
MATERIALS TODAY ADVANCES
(2022)
Review
Cell Biology
Hongfu Jin, Shigang Jiang, Ruomei Wang, Yi Zhang, Jiangtao Dong, Yusheng Li
Summary: Integrins, a family of transmembrane proteins, play essential roles in osteoarthritis (OA). Dysfunction of integrins has been shown to be involved in the pathogenesis of OA. Understanding the roles of integrins in OA may influence the development of future treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Yuting Xia, Yuandong Yu, Yi Zhao, Zhifen Deng, Lei Zhang, Guizhao Liang
Summary: The study reveals that vitamin D supplementation can significantly reduce triglyceride levels and improve insulin resistance in MetS. It identifies 14 core genes associated with MetS and highlights the potential of vitamin D to modulate the PPAR signaling pathway. The study emphasizes the need for further research to confirm these findings and explore genetic variability in response to vitamin D.
Article
Astronomy & Astrophysics
Y. P. Chen, S. Zhang, S. N. Zhang, L. Ji, L. D. Kong, P. J. Wang, L. Tao, M. Y. Ge, C. Z. Liu, F. J. Lu, J. L. Qu, T. P. Li, Y. P. Xu, X. L. Cao, Y. Chen, Q. C. Bu, C. Cai, Z. Chang, L. Chen, T. X. Chen, Y. B. Chen, W. W. Cui, Y. Y. Du, G. H. Gao, H. Gao, Y. D. Gu, J. Guan, C. C. Guo, D. W. Han, Y. Huang, J. Huo, S. M. Jia, W. C. Jiang, J. Jin, B. Li, C. K. Li, G. Li, W. Li, X. Li, X. B. Li, X. F. Li, Z. W. Li, X. H. Liang, J. Y. Liao, B. S. Liu, H. W. Liu, H. X. Liu, X. J. Liu, X. F. Lu, Q. Luo, T. Luo, R. C. Ma, X. Ma, B. Meng, Y. Nang, J. Y. Nie, G. Ou, X. Q. Ren, N. Sai, L. M. Song, X. Y. Song, L. Sun, Y. Tan, Y. L. Tuo, C. Wang, L. J. Wang, W. S. Wang, Y. S. Wang, X. Y. Wen, B. B. Wu, B. Y. Wu, M. Wu, G. C. Xiao, S. Xiao, S. L. Xiong, R. J. Yang, S. Yang, Y. J. Yang, Y. J. Yang, Q. B. Yi, Q. Q. Yin, Y. You, F. Zhang, H. M. Zhang, J. Zhang, P. Zhang, W. C. Zhang, W. Zhang, Y. F. Zhang, Y. H. Zhang, H. S. Zhao, X. F. Zhao, S. J. Zheng, Y. G. Zheng, D. K. Zhou
Summary: The study reveals that in the type-II X-ray bursts of MXB 1730-335, hard X-rays lag behind soft X-rays by 3 seconds, providing a new perspective for research. The energy spectrum of all bursts is nonthermal, indicating the possible presence of a coronal source.
ASTROPHYSICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Yasuko Arao, Mika Nakayama, Yoshiko Tsuji, Yumiko Hamano, Chihiro Otsuka, Andrea Vecchione, Ken Ofusa, Hideshi Ishii
Summary: MicroRNAs (miRNAs) synthesized through a canonical pathway play important roles in human diseases. IsomiRs, variations in noncoding miRNAs, are generated through a non-canonical pathway. EpisomiRs, miRNAs with different modifications, are expanding the isomiR family. IsomiRs reflect cell-specific biological function and studying episomiRs and isomiRs can contribute to optimizing diagnosis and therapeutic technology for precision medicine.
Review
Medicine, Research & Experimental
Jiaoyang Ning, Yi Luo, Liu Chen, Gang Xiao, Guilong Tanzhu, Rongrong Zhou
Summary: This article provides an overview of the expression patterns and prognostic significance of circRNAs in lung cancer, and summarizes the clinical relevance of circRNAs in lung cancer metastasis. Furthermore, it focuses on the roles of circRNAs in each step of lung cancer metastasis, demonstrating their dual functionality as both facilitators and inhibitors of metastatic processes. Due to their potential, circRNAs hold promise as novel biomarkers and therapeutic targets for lung cancer metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Zaira Ianniello, Melissa Sorci, Lavinia Ceci Ginistrelli, Alessia Iaiza, Marcella Marchioni, Claudia Tito, Ernestina Capuano, Silvia Masciarelli, Tiziana Ottone, Cristina Attrotto, Manuela Rizzo, Luca Franceschini, Stefano de Pretis, Maria Teresa Voso, Mattia Pelizzola, Francesco Fazi, Alessandro Fatica
Summary: The upregulation of the METTL3/METTL14 protein complex in patients with chronic myeloid leukemia (CML) is crucial for cell proliferation. Depletion of METTL3 impairs global translation efficiency and affects the expression of genes involved in ribosome biogenesis and translation. METTL3 is identified as a novel relevant oncogene in CML and a promising therapeutic target for TKI-resistant CML.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Deepankar Mondal, Sapnita Shinde, Souvik Paul, Suresh Thakur, Gsk Velu, Atul Kumar Tiwari, Vineeta Dixit, Ajay Amit, Naveen Kumar Vishvakarma, Dhananjay Shukla
Summary: T-cell malignancy refers to the disease subtypes where malignant T cells are transformed at different stages. MicroRNAs (miRNAs) can be used as diagnostic tools for distinguishing different tumor subtypes within T-cell malignancies. miRNA plays an important role in the diagnosis of T-cell malignancies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Plant Sciences
Simon Strobbe, Jana Verstraete, Christophe Stove, Dominique Van Der Straeten
Summary: In this study, metabolic engineering strategies were examined in Arabidopsis thaliana to increase thiamin levels in plants. The research revealed the necessity to balance the pyrimidine and thiazole branches of thiamin biosynthesis, and assessed its biosynthetic intermediates, providing guidelines for the development of novel metabolic engineering strategies for thiamin.
Review
Immunology
Weiyi Jiang, Zilong Deng, Xingzhu Dai, Wanghong Zhao
Summary: The dysbiosis of the oral microbiome leads to oral infectious diseases, and the study of cell death pathways has revealed the important role of PANoptosis in infectious diseases, autoimmunity, and cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Yufeng Xi, Yujia Wang
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly occurring in premature infants, with pathological manifestations of alveolar hypoplasia and dysregulation of pulmonary vasculature development. Non-coding RNAs play a crucial role in the incidence and development of BPD by regulating gene expression, serving as potential molecular markers and therapeutic targets for BPD diagnosis and treatment.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Mengyu Dai, Xiaoying Yang, Yinghua Yu, Wei Pan
Summary: The study highlights that helminth infection may alleviate obesity and metabolic syndromes through various mechanisms, including inducing macrophage M2 polarization, inhibiting adipogenesis, promoting fat browning, and improving glucose tolerance and metabolic inflammation. Additionally, helminth infection may also affect obesity and metabolic syndromes by altering the host's gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiaofang Yin, Guisong Zhu, Qian Wang, Yuan Dong Fu, Juan Wang, Biao Xu
Summary: ALI, a common and critical illness, is influenced by oxidative stress, while ferroptosis, a newly discovered programmed cell death, has been found to play a role in the pathophysiological process of ALI.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Shiyi Liang, Weicheng Xv, Chijian Li, Yuxiang Huang, Ge Qian, Yuxiang Yan, Hequn Zou, Yongqiang Li
Summary: This review summarizes the recent progress of LncRNAs in the development of atherosclerosis, highlighting their diverse regulatory mechanisms at the transcriptional and post-transcriptional levels, and provides insights into their potential as therapeutic targets or biomarkers for atherosclerosis treatment.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2022)
