Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants

Helminth secretomes reflect different lifestyles and parasitized hosts

(2017) Yesid Cuesta-Astroz et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is a fatty acid-binding protein

(2017) Rabih Darwiche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significant effects of RNAi silencing of the venom allergen-like protein (Mhi-vap-1 ) of the root-knot nematode Meloidogyne hispanica in the early events of infection

(2017) A. Duarte et al.   PLANT PATHOLOGY

Revisiting the Ancylostoma Caninum Secretome Provides New Information on Hookworm-Host Interactions

(2017) Taylor Morante et al.   PROTEOMICS

Niche-specific gene expression in a parasitic nematode; increased expression of immunomodulators in Teladorsagia circumcincta larvae derived from host mucosa

(2017) Tom N. McNeilly et al.   Scientific Reports

Regulation of the host immune system by helminth parasites

(2016) Rick M. Maizels et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dual RNA-seq revealsMeloidogyne graminicolatranscriptome and candidate effectors during the interaction with rice plants

(2016) Anne-Sophie Petitot et al.   MOLECULAR PLANT PATHOLOGY

The genomic basis of parasitism in the Strongyloides clade of nematodes

(2016) Vicky L Hunt et al.   NATURE GENETICS

CAP protein superfamily members in Toxocara canis

(2016) Andreas J. Stroehlein et al.   Parasites & Vectors

The barber's pole worm CAP protein superfamily — A basis for fundamental discovery and biotechnology advances

(2015) Namitha Mohandas et al.   BIOTECHNOLOGY ADVANCES

The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets

(2015) Gisela R. Franchini et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection

(2015) James P. Hewitson et al.   PLoS Pathogens

The Activation and Suppression of Plant Innate Immunity by Parasitic Nematodes

(2014) Aska Goverse et al.   Annual Review of Phytopathology

Characterization of the venom allergen—like protein (vap-1) and the fatty acid and retinol binding protein (far-1) genes in Meloidogyne hispanica

(2014) Aida Duarte et al.   EUROPEAN JOURNAL OF PLANT PATHOLOGY

Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression

(2014) Timothy P. Yoshino et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Probing the equatorial groove of the hookworm protein and vaccine candidate antigen, Na-ASP-2

(2014) Lyndel Mason et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Probing of a Human Proteome Microarray With a Recombinant Pathogen Protein Reveals a Novel Mechanism by Which Hookworms Suppress B-Cell Receptor Signaling

(2014) Leon Tribolet et al.   JOURNAL OF INFECTIOUS DISEASES

Secreted Proteomes of Different Developmental Stages of the Gastrointestinal NematodeNippostrongylus brasiliensis

(2014) Javier Sotillo et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome of the human hookworm Necator americanus

(2014) Yat T Tang et al.   NATURE GENETICS

Apoplastic Venom Allergen-like Proteins of Cyst Nematodes Modulate the Activation of Basal Plant Innate Immunity by Cell Surface Receptors

(2014) Jose L. Lozano-Torres et al.   PLoS Pathogens

Schistosoma mansonivenom allergen-like protein 4 (SmVAL4) is a novel lipid-binding SCP/TAPS protein that lacks the prototypical CAP motifs

(2014) Alan Kelleher et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure ofOstertagia ostertagiASP-1: insights into disulfide-mediated cyclization and dimerization

(2013) Jimmy Borloo et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Transcriptome analyses reveal protein and domain families that delineate stage-related development in the economically important parasitic nematodes, Ostertagia ostertagi and Cooperia oncophora

(2013) Esley Heizer et al.   BMC GENOMICS

Exploring the Host Parasitism of the Migratory Plant-Parasitic Nematode Ditylenchus destuctor by Expressed Sequence Tags Analysis

(2013) Huan Peng et al.   PLoS One

Comparative transcriptomics of two pathogenic pinewood nematodes yields insights into parasitic adaptation to life on pine hosts

(2012) Xia Yan et al.   GENE

Tissue expression patterns of Schistosoma mansoni Venom Allergen-Like proteins 6 and 7

(2012) Henrique K. Rofatto et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths

(2012) David J. Diemert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structure of Protein Having Inhibitory Disintegrin and Leukotriene Scavenging Functions Contained in Single Domain

(2012) Xueqing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual disease resistance mediated by the immune receptor Cf-2 in tomato requires a common virulence target of a fungus and a nematode

(2012) J. L. Lozano-Torres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins

(2012) V. Choudhary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a two-CAP-domain protein from the human hookworm parasiteNecator americanus

(2011) Oluwatoyin A. Asojo   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural studies of human glioma pathogenesis-related protein 1

(2011) Oluwatoyin A. Asojo et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Hookworm SCP/TAPS protein structure—A key to understanding host–parasite interactions and developing new interventions

(2011) Asiah Osman et al.   BIOTECHNOLOGY ADVANCES

Molecular properties of a venom allergen-like protein suggest a parasitic function in the pinewood nematode Bursaphelenchus xylophilus

(2011) Jae Soon Kang et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of Venom Allergen-Like (VAL) proteins

(2011) James P. Hewitson et al.   Journal of Proteomics

SCP/TAPS proteins in helminths – Where to from now?

(2011) Cinzia Cantacessi et al.   MOLECULAR AND CELLULAR PROBES

Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens

(2011) Judith E. Allen et al.   PLoS Pathogens

Human CRISP-3 binds serum α1B-glycoprotein across species

(2010) Lene Udby et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cobra CRISP Functions as an Inflammatory Modulator via a Novel Zn2+- and Heparan Sulfate-dependent Transcriptional Regulation of Endothelial Cell Adhesion Molecules

(2010) Yu-Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of GAPR-1 to negatively charged phospholipid membranes: Unusual binding characteristics to phosphatidylinositol

(2010) Josse Van Galen et al.   MOLECULAR MEMBRANE BIOLOGY

A portrait of the “SCP/TAPS” proteins of eukaryotes — Developing a framework for fundamental research and biotechnological outcomes

(2009) C. Cantacessi et al.   BIOTECHNOLOGY ADVANCES

A phylogenetic tree of nematodes based on about 1200 full-length small subunit ribosomal DNA sequences

(2009) Hanny van Megen et al.   NEMATOLOGY

Identification and Characterization of the Most Abundant Cellulases in Stylet Secretions fromGlobodera rostochiensis

(2009) Sajid Rehman et al.   PHYTOPATHOLOGY

Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

(2008) Iain W Chalmers et al.   BMC GENOMICS

The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins—Roles in Reproduction, Cancer, and Immune Defense

(2008) Gerard M. Gibbs et al.   ENDOCRINE REVIEWS

Ascidian Sperm Glycosylphosphatidylinositol-anchored CRISP-like Protein as a Binding Partner for an Allorecognizable Sperm Receptor on the Vitelline Coat

(2008) Satoshi Urayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Changes in the Hookworm, Ancylostoma caninum, during the Transition from a Free-Living to a Parasitic Larva

(2008) Bennett J. D. Datu et al.   PLoS Neglected Tropical Diseases

Proteomic Analysis of Skin Invasion by Blood Fluke Larvae

(2008) Elizabeth Hansell et al.   PLoS Neglected Tropical Diseases

The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, Necator americanus

(2007) Shuhua Xiao et al.   EXPERIMENTAL PARASITOLOGY

Necator americanus: The Na-ASP-2 protein secreted by the infective larvae induces neutrophil recruitment in vivo and in vitro

(2007) Molly A. Bower et al.   EXPERIMENTAL PARASITOLOGY