A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types

Recon3D enables a three-dimensional view of gene variation in human metabolism

(2018) Elizabeth Brunk et al.   NATURE BIOTECHNOLOGY

Fatty Acid Supplementation Reverses the Small Colony Variant Phenotype in Triclosan-Adapted Staphylococcus aureus: Genetic, Proteomic and Phenotypic Analyses

(2018) Abdulrahman S. Bazaid et al.   Scientific Reports

iML1515, a knowledgebase that computes Escherichia coli traits

(2017) Jonathan M Monk et al.   NATURE BIOTECHNOLOGY

Amino Acid Catabolism in Staphylococcus aureus and the Function of Carbon Catabolite Repression

(2017) Cortney R. Halsey et al.   mBio

Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection

(2017) Matthew Wickersham et al.   Cell Reports

Erroneous energy-generating cycles in published genome scale metabolic networks: Identification and removal

(2017) Claus Jonathan Fritzemeier et al.   PLoS Computational Biology

The Staphylococcus aureus α-Acetolactate Synthase ALS Confers Resistance to Nitrosative Stress

(2017) Sandra M. Carvalho et al.   Frontiers in Microbiology

Utilization of glycerophosphodiesters byStaphylococcus aureus

(2016) Ana Maria Jorge et al.   MOLECULAR MICROBIOLOGY

The role of two branched-chain amino acid transporters inStaphylococcus aureusgrowth, membrane fatty acid composition and virulence

(2016) Julienne C. Kaiser et al.   MOLECULAR MICROBIOLOGY

Comparative genome-scale modelling ofStaphylococcus aureusstrains identifies strain-specific metabolic capabilities linked to pathogenicity

(2016) Emanuele Bosi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus

(2016) C. Denise Appel et al.   PROTEIN SCIENCE

Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus

(2016) G. Ghssein et al.   SCIENCE

Expanded Glucose Import Capability Affords Staphylococcus aureus Optimized Glycolytic Flux during Infection

(2016) Nicholas P. Vitko et al.   mBio

CtaM Is Required for Menaquinol Oxidase aa 3 Function in Staphylococcus aureus

(2016) Neal D. Hammer et al.   mBio

The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone

(2016) Kristoffer T. Bæk et al.   mBio

Multi-omic data integration enables discovery of hidden biological regularities

(2016) Ali Ebrahim et al.   Nature Communications

Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis

(2016) Catherine Dunyach-Remy et al.   Toxins

Using Genome-scale Models to Predict Biological Capabilities

(2015) Edward J. O’Brien et al.   CELL

Synthesis and function of phospholipids in Staphylococcus aureus

(2015) Sebastian Kuhn et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Bacillithiol has a role in Fe-S cluster biogenesis inStaphylococcus aureus

(2015) Zuelay Rosario-Cruz et al.   MOLECULAR MICROBIOLOGY

Type-II NADH:quinone oxidoreductase from Staphylococcus aureushas two distinct binding sites and is rate limited by quinone reduction

(2015) Filipa V. Sena et al.   MOLECULAR MICROBIOLOGY

BiGG Models: A platform for integrating, standardizing and sharing genome-scale models

(2015) Zachary A. King et al.   NUCLEIC ACIDS RESEARCH

Structural insights into species-specific features of the ribosome from the pathogenStaphylococcus aureus

(2015) Zohar Eyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens

(2015) Leo Lin et al.   EBioMedicine

Relaxed tRNA specificity of theStaphylococcus aureusaspartyl-tRNA synthetase enables RNA-dependent asparagine biosynthesis

(2014) Stefani R. Mladenova et al.   FEBS LETTERS

Identification of Point Mutations in Clinical Staphylococcus aureus Strains That Produce Small-Colony Variants Auxotrophic for Menadione

(2014) Melissa A. Dean et al.   INFECTION AND IMMUNITY

Influence of Iron and Aeration on Staphylococcus aureus Growth, Metabolism, and Transcription

(2014) N. Ledala et al.   JOURNAL OF BACTERIOLOGY

The Staphylococcus aureus NuoL-Like Protein MpsA Contributes to the Generation of Membrane Potential

(2014) Sonja Mayer et al.   JOURNAL OF BACTERIOLOGY

Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence inStaphylococcus aureus

(2014) Ameya A. Mashruwala et al.   MOLECULAR MICROBIOLOGY

Glycerol Uptake Is Important for L-Form Formation and Persistence in Staphylococcus aureus

(2014) Jian Han et al.   PLoS One

Predicting microbial growth

(2014) J. Monk et al.   SCIENCE

Nutrient Limitation Governs Staphylococcus aureus Metabolism and Niche Adaptation in the Human Nose

(2014) Bernhard Krismer et al.   PLoS Pathogens

COBRApy: COnstraints-Based Reconstruction and Analysis for Python

(2013) Ali Ebrahim et al.   BMC Systems Biology

MntABC and MntH Contribute to Systemic Staphylococcus aureus Infection by Competing with Calprotectin for Nutrient Manganese

(2013) Thomas E. Kehl-Fie et al.   INFECTION AND IMMUNITY

Structural Systems Biology Evaluation of Metabolic Thermotolerance in Escherichia coli

(2013) R. L. Chang et al.   SCIENCE

Thiamin (Vitamin B1) Biosynthesis and Regulation: A Rich Source of Antimicrobial Drug Targets?

(2012) Qinglin Du et al.   International Journal of Biological Sciences

Analysis of omics data with genome-scale models of metabolism

(2012) Daniel R. Hyduke et al.   Molecular BioSystems

Menaquinone biosynthesis potentiates haem toxicity inStaphylococcus aureus

(2012) Catherine A. Wakeman et al.   MOLECULAR MICROBIOLOGY

TheStaphylococcus aureusOpp1 ABC transporter imports nickel and cobalt in zinc-depleted conditions and contributes to virulence

(2012) Laetitia Remy et al.   MOLECULAR MICROBIOLOGY

CcpA Regulates Arginine Biosynthesis in Staphylococcus aureus through Repression of Proline Catabolism

(2012) Austin S. Nuxoll et al.   PLoS Pathogens

A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011

(2011) J. D. Orth et al.   Molecular Systems Biology

Identification of a Lactate-Quinone Oxidoreductase in Staphylococcus aureus that is Essential for Virulence

(2011) James R. Fuller et al.   Frontiers in Cellular and Infection Microbiology

Structure of dihydroorotase fromBacillus anthracisat 2.6 Å resolution

(2010) Shahila Mehboob et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Molecular Mechanisms ofStaphylococcus aureusIron Acquisition

(2010) Neal D. Hammer et al.   Annual Review of Microbiology

A Metabolomic View of Staphylococcus aureus and Its Ser/Thr Kinase and Phosphatase Deletion Mutants: Involvement in Cell Wall Biosynthesis

(2010) Manuel Liebeke et al.   CHEMISTRY & BIOLOGY

The biomass objective function

(2010) Adam M Feist et al.   CURRENT OPINION IN MICROBIOLOGY

Golden Pigment Production and Virulence Gene Expression Are Affected by Metabolisms in Staphylococcus aureus

(2010) L. Lan et al.   JOURNAL OF BACTERIOLOGY

A nickel ABC-transporter of Staphylococcus aureus is involved in urinary tract infection

(2010) Aurelia Hiron et al.   MOLECULAR MICROBIOLOGY

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

A protocol for generating a high-quality genome-scale metabolic reconstruction

(2010) Ines Thiele et al.   Nature Protocols

Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

(2010) Roger L. Chang et al.   PLoS Computational Biology

Dual Role of the Oligopeptide Permease Opp3 during Growth of Staphylococcus aureus in Milk

(2009) E. Borezee-Durant et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification and Characterization of theStaphylococcus aureusGene Cluster Coding for Staphyloferrin A†

(2009) Jennifer L. Cotton et al.   BIOCHEMISTRY

Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify Novel Antimicrobial Drug Targets

(2009) D.-S. Lee et al.   JOURNAL OF BACTERIOLOGY

CymR, the master regulator of cysteine metabolism inStaphylococcus aureus, controls host sulphur source utilization and plays a role in biofilm formation

(2009) Olga Soutourina et al.   MOLECULAR MICROBIOLOGY

Molecular characterization of staphyloferrin B biosynthesis inStaphylococcus aureus

(2009) Johnson Cheung et al.   MOLECULAR MICROBIOLOGY

Identification of the Genetic Basis for Clinical Menadione-Auxotrophic Small-Colony Variant Isolates of Staphylococcus aureus

(2008) J. Lannergard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tricarboxylic Acid Cycle-Dependent Regulation of Staphylococcus epidermidis Polysaccharide Intercellular Adhesin Synthesis

(2008) M. R. Sadykov et al.   JOURNAL OF BACTERIOLOGY

Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood

(2008) Shalaka Samant et al.   PLoS Pathogens

Analysis of the Staphylococcus aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases

(2008) Darcie J. Miller et al.   STRUCTURE