Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway

Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1

(2015) Young Min Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia

(2014) Yun Yuan et al.   BMC NEUROSCIENCE

The kynurenine pathway is involved in bacterial meningitis

(2014) Leonam G Coutinho et al.   Journal of Neuroinflammation

High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis

(2013) Christopher Höhne et al.   BRAIN

Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis

(2013) Anisha A. Gupte et al.   Current Diabetes Reports

A tetrahydroisoquinoline alkaloid THI-28 reduces LPS-induced HMGB1 and diminishes organ injury in septic mice through p38 and PI3K/Nrf2/HO-1 signals

(2013) Hee Sook Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cerebrospinal Fluid TNF-α, IL-6, and IL-8 in Children With Bacterial Meningitis

(2013) Rajniti Prasad et al.   PEDIATRIC NEUROLOGY

The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

(2013) Eun Jung Park et al.   PLoS One

Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adult Wistar rats subjected to pneumococcal meningitis

(2013) Tatiana Barichello et al.   Translational Research

Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy

(2012) Somasundaram Arumugam et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

In Vivo and In Vitro Treatment With Edaravone Promotes Proliferation of Neural Progenitor Cells Generated Following Neuronal Loss in the Mouse Dentate Gyrus

(2012) Maho Kikuta et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Antioxidant treatment prevents cognitive impairment and oxidative damage in pneumococcal meningitis survivor rats

(2012) Tatiana Barichello et al.   METABOLIC BRAIN DISEASE

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Pathogenesis and Pathophysiology of Pneumococcal Meningitis

(2011) B. B. Mook-Kanamori et al.   CLINICAL MICROBIOLOGY REVIEWS

High Mobility Group Box 1 in Cerebrospinal Fluid From Several Neurological Diseases at Early Time Points

(2011) Takeshi Asano et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Bacterial Meningitis in the United States, 1998–2007

(2011) Michael C. Thigpen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term Sequelae of Childhood Bacterial Meningitis

(2010) Aruna Chandran et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis*

(2009) Daolin Tang et al.   CRITICAL CARE MEDICINE

The Free Radical Scavenger Edaravone Rescues Rats from Cerebral Infarction by Attenuating the Release of High-Mobility Group Box-1 in Neuronal Cells

(2009) K. Kikuchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Novel Antioxidant Edaravone: From Bench to Bedside

(2008) Toshiaki Watanabe et al.   Cardiovascular Therapeutics

Edaravone Attenuates Brain Edema and Neurologic Deficits in a Rat Model of Acute Intracerebral Hemorrhage

(2007) Takehiro Nakamura et al.   STROKE