Article
Nutrition & Dietetics
Chen Li, Peirong Lu
Summary: This study examined the correlation between gut microbiota and both age-related macular degeneration (AMD) and glaucoma. The findings suggest that certain gut bacteria have protective effects on AMD, while others may be risk factors for AMD or glaucoma. Reverse analysis also found that glaucoma led to an increased abundance of certain gut bacteria. Further research is needed to understand the specific mechanisms involved.
Review
Microbiology
Gianluca Scuderi, Emidio Troiani, Angelo Maria Minnella
Summary: This article discusses the importance of the gut microbiome and its relationship to ocular health. By introducing the characteristics and functions of the gut microbiome, it highlights the role of gut microbiome dysbiosis in the development of retinal diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Ophthalmology
Marie-Agnes Bringer, Pierre-Henry Gabrielle, Alain M. Bron, Catherine Creuzot-Garcher, Niyazi Acar
Summary: The gut microbiota is a complex ecosystem that coevolves dynamically with the host, playing a crucial role in maintaining the balance between health and disease. Imbalance in gut microbial communities, known as dysbiosis, has been associated with various inflammatory, metabolic diseases, and central nervous system disorders.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Mario Lima-Fontes, Luis Meira, Pedro Barata, Manuel Falcao, Angela Carneiro
Summary: Age-related macular degeneration (AMD) is a leading cause of severe, irreversible vision impairment in developed countries, and its prevalence is rising worldwide. The relationship between gut microbiota and AMD has been a recent focus of research.
SURVEY OF OPHTHALMOLOGY
(2022)
Review
Food Science & Technology
Kristin Krueger, Elke Boehme, Alexa Karina Klettner, Marietta Zille
Summary: Vision is crucial for obtaining information about the environment, and diet plays a significant role in the development of retinal diseases. Marine resources, particularly fish intake and omega-3 fatty acids, have shown promising results in preventing retinal diseases, but the underlying mechanisms are not fully explained.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Hong Jiang, Xin Shi, Yahui Fan, Duolao Wang, Baoyu Li, Jin Zhou, Cheng Pei, Le Ma
Summary: The study found that a high intake of dietary omega-3 PUFA or fish is associated with a reduced risk of developing AMD, particularly early and late AMD. An additional 1 g/d intake of omega-3 PUFA was associated with a 6% and 22% decrease in the risk of early and late AMD, respectively.
CLINICAL NUTRITION
(2021)
Article
Oncology
Tengteng Wang, Nicole M. Brown, Amber N. McCoy, Robert S. Sandler, Temitope O. Keku
Summary: This study investigates the relationship between Omega-3 PUFAs and CRAs and finds an inverse association between Omega-3 PUFAs and CRAs, which may be influenced by gut microbiota.
Editorial Material
Food Science & Technology
Emanuele Rinninella, Lara Costantini
Summary: The International Scientific Association for Probiotics and Prebiotics (ISAPP) considers polyunsaturated fatty acids (PUFAs) as candidate prebiotics, although there is a lack of complete scientific evidence. Recent partial evidence shows that metabolites of PUFAs can have important health effects in the host, supporting the concept of the prebiotic action of PUFAs.
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Shinichi Fukuda, Akhil Varshney, Benjamin J. Fowler, Shao-bin Wang, Siddharth Narendran, Kameshwari Ambati, Tetsuhiro Yasuma, Joseph Magagnoli, Hannah Leung, Shuichiro Hirahara, Yosuke Nagasaka, Reo Yasuma, Ivana Apicella, Felipe Pereira, Ryan D. Makin, Eamonn Magner, Xinan Liu, Jian Sun, Mo Wang, Kirstie Baker, Kenneth M. Marion, Xiwen Huang, Elmira Baghdasaryan, Meenakshi Ambati, Vidya L. Ambati, Akshat Pandey, Lekha Pandya, Tammy Cummings, Daipayan Banerjee, Peirong Huang, Praveen Yerramothu, Genrich Tolstonog, Ulrike Held, Jennifer A. Erwin, Apua C. M. Paquola, Joseph R. Herdy, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Shaban Darwish, Ramendra K. Singh, Saghar Mozaffari, Deepak Bhattarai, Kyung Bo Kim, James W. Hardin, Charles L. Bennett, David R. Hinton, Timothy E. Hanson, Christian Rover, Keykavous Parang, Nagaraj Kerur, Jinze Liu, Brian C. Werner, S. Scott Sutton, Srinivas R. Sadda, Gerald G. Schumann, Bradley D. Gelfand, Fred H. Gage, Jayakrishna Ambati
Summary: Alu retrotransposons propagate through reverse transcription using L1 elements, with cytoplasmic Alu cDNA inducing retinal pigmented epithelium degeneration independently of integration. Inhibitors of this process may be potential therapies for atrophic macular degeneration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Jinghua Jiao, Honghua Yu, Litong Yao, Lihua Li, Xiaohong Yang, Lei Liu
Summary: The health of the gut microbiome is related to various diseases, including diabetic retinopathy. Recent studies suggest a possible connection between gut microbiome dysbiosis and ocular diseases, leading to novel therapeutic strategies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Pardis Kaynezhad, Ilias Tachtsidis, Asmaa Aboelnour, Sobha Sivaprasad, Glen Jeffery
Summary: Optical examination of retinal mitochondrial function and choroidal oxygenation and hemodynamics in aging mice models of macular degeneration revealed that mitochondrial decline precedes age-related changes to choroidal vasculature, disrupting hemodynamic oscillations. This non-invasive technique offers real-time detection of early retinal disease and its relationship to blood oxygenation.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Yuanyuan Zhang, Tianyu Wang, Zhongqi Wan, Jianhao Bai, Yawen Xue, Rushun Dai, Minli Wang, Qing Peng
Summary: This study aimed to investigate the relationship between intestinal microbiota and age-related macular degeneration (AMD) patients. The study found significant differences in the composition of intestinal microbiota between AMD patients and healthy controls, and these differences may be related to the pathophysiology of AMD. Therefore, intestinal microbiota may serve as non-invasive indicators for AMD clinical diagnosis and possibly as targets for AMD treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Beatriz Villarejo-Zori, Juan Ignacio Jimenez-Loygorri, Juan Zapata-Munoz, Katharina Bell, Patricia Boya
Summary: Autophagy is a crucial quality control mechanism in cells, particularly in non-dividing cells like neurons. The retina, a light-sensitive tissue in the eye, is exposed to various stressors and requires autophagy for maintaining homeostasis. Understanding the role of autophagy in retinal function and eye diseases may lead to potential therapeutic strategies.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Ophthalmology
Liangbo L. Shen, Mengyuan Sun, Aneesha Ahluwalia, Michael M. Park, Benjamin K. Young, Eleonora M. Lad, Cynthia Toth, Lucian Del Priore
Summary: This study tracked the progression of eyes with geographic atrophy (GA) involving the central 1 mm diameter zone and found that the central residual effective radius (CRER) declined linearly over approximately 13 years. This finding suggests that CRER could serve as an anatomical endpoint in future clinical trials aiming to preserve the central zone.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Nutrition & Dietetics
Ilaria Trestini, Alberto Caldart, Marco Cintoni, Isabella Sperduti, Alessandro Drudi, Gregorio Aluffi, Elena Fiorio, Veronica Parolin, Valentina Zambonin, Sara Zanelli, Daniela Tregnago, Alice Avancini, Sara Pilotto, Irene Aprili, Emanuela Zandona, Mirko D'Onofrio, Maria Cristina Mele, Antonio Gasbarrini, Giovanni Scambia, Giampaolo Tortora, Michele Milella, Emilio Bria, Luisa Carbognin
Summary: This study evaluated the changes in body composition during neoadjuvant chemotherapy and its association with pathologic complete response and survival outcome in patients treated for operable locally advanced breast cancer.
Review
Nutrition & Dietetics
Emanuele Rinninella, Pauline Raoul, Valeria Maccauro, Marco Cintoni, Andrea Cambieri, Alberto Fiore, Maurizio Zega, Antonio Gasbarrini, Maria Cristina Mele
Summary: This systematic review examined the impact of different hospital services on patients' nutritional intake and food waste. The findings suggest that personalized food service and efficient room service can improve nutritional intake while reducing food waste. In addition, active monitoring and intervention by clinical nutritionists, especially dietitians, can increase patients' food consumption.
Article
Gastroenterology & Hepatology
Emanuele Rinninella, Ege Tohumcu, Pauline Raoul, Marcello Fiorani, Marco Cintoni, Maria Cristina Mele, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro
Summary: Gut microbiota plays a crucial role in human health and has significant impacts on the body. Diet has a powerful influence on the functions and composition of gut microbiota, involving the immune system and the intestinal barrier. In this review article, we discuss the effects of specific dietary nutrients and patterns on the composition of human gut microbiota, as well as the potential application of diet as a therapeutic modulator for gut microbiota.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Alberto Nicoletti, Maria Elena Ainora, Marco Cintoni, Matteo Garcovich, Barbara Funaro, Silvia Pecere, Martina De Siena, Francesco Santopaolo, Francesca Romana Ponziani, Laura Riccardi, Antonio Grieco, Maurizio Pompili, Antonio Gasbarrini, Maria Assunta Zocco
Summary: This study evaluated the changes in liver stiffness (LS) in HCV cirrhotic patients undergoing DAA therapy and identified parameters that predict the occurrence of liver-related events. The results showed that LS changes and MELD score were associated with HCC risk, while a one-year Delta-LS < 20% was associated with the development of ascites.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Medicine, General & Internal
Lucrezia Laterza, Marco Napoli, Valentina Petito, Franco Scaldaferri, Eleonora Gaetani, Antonio Gasbarrini
Summary: This study evaluated the adherence to probiotic therapy in real-life and identified factors that influenced adherence. It found that 60% of patients took all the prescribed probiotic therapy and perceived benefits in more than 60% of cases. The main factors affecting adherence were the price of the product, mild adverse events, and poor appreciation of flavor.
Article
Nutrition & Dietetics
Emanuele Rinninella, Raffaele Borriello, Marco D'Angelo, Tiziano Galasso, Marco Cintoni, Pauline Raoul, Michele Impagnatiello, Brigida Eleonora Annicchiarico, Antonio Gasbarrini, Maria Cristina Mele
Summary: Hospital malnutrition affects a significant portion of patients, and early assessment using the CONUT score can help predict hospital outcomes. This study aimed to determine the predictive role of the CONUT score in an Italian hospital, finding that CONUT was a reliable predictor of length of stay and in-hospital mortality.
Article
Nutrition & Dietetics
William Fusco, Manuel Bernabeu Lorenzo, Marco Cintoni, Serena Porcari, Emanuele Rinninella, Francesco Kaitsas, Elena Lener, Maria Cristina Mele, Antonio Gasbarrini, Maria Carmen Collado, Giovanni Cammarota, Gianluca Ianiro
Summary: Short-chain fatty acids (SCFAs) are crucial for gut health and have implications in various diseases. They are produced by specific bacterial taxa in the gut microbiota and can be influenced by specific foods or supplements. This review provides an overview of SCFAs, their production by bacteria, and potential therapeutic approaches to boost their levels and treat related diseases.
Article
Nutrition & Dietetics
Marialaura Scarcella, Emidio Scarpellini, Sara Piergallini, Emanuele Rinninella, Karen Routhiaux, Carlo Rasetti, Ludovico Abenavoli, Edoardo De Robertis, Pietro Manzi, Rita Commissari, Riccardo Monti, Michela Zanetti
Summary: In this study, we found that immune-nutrition (IN) can prevent malnutrition and decrease inflammatory markers in overweight patients with COVID-19 during the fourth wave of the pandemic in 2021.
Review
Chemistry, Multidisciplinary
Elisabetta Sforza, Domenico Limongelli, Valentina Giorgio, Gaia Margiotta, Francesco Proli, Eliza Maria Kuczynska, Chiara Leoni, Donato Rigante, Ilaria Contaldo, Chiara Veredice, Emanuele Rinninella, Antonio Gasbarrini, Giuseppe Zampino, Roberta Onesimo
Summary: This study aimed to describe and quantify the impact of blenderized tube feeding (BTF) on gastrointestinal symptoms in children and adults. The results showed that gastrointestinal symptoms improved after consuming BTF, with a decrease of 30-50% in gagging and retching for children and similar improvement rates for constipation and diarrhea in most critically ill adults.
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, General & Internal
Alessio Filippone, Cristina Rossi, Maria Maddalena Rossi, Annalisa Di Micco, Claudia Maggiore, Luana Forcina, Maria Natale, Lara Costantini, Nicolo Merendino, Alba Di Leone, Gianluca Franceschini, Riccardo Masetti, Stefano Magno
Summary: The gut microbiota plays a significant role in the development and treatment of hormone-dependent breast cancer, through its influence on sexual hormonal balance and interaction with endocrine disruptors and phytoestrogens.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Microbiology
Pauline Raoul, Marco Cintoni, Emanuele Rinninella, Maria Cristina Mele
Article
Obstetrics & Gynecology
Elisa Scarinci, Giovanna Notaristefano, Anna Tropea, Simone M. Fabozzi, Ornella Alesiani, Elisabetta Meucci, Andrea Silvestrini, Marco Cintoni, Alice Diterlizzi, Antonio Lanzone, Rosanna Apa
Summary: This study investigated the effects of alpha-lipoic acid treatment on clinical, endocrine, and metabolic features of women with polycystic ovary syndrome (PCOS). The results showed that alpha-lipoic acid restored menstrual cyclicity, improved metabolic function, and increased antioxidant capacity. Despite the unclear mechanism of action, it could be considered as a valid alternative to traditional drugs.
MINERVA OBSTETRICS AND GYNECOLOGY
(2023)