Review
Medicine, Research & Experimental
Huan Zhang, Xueqi Wan, Jinfan Tian, Ziyu An, Libo Liu, Xin Zhao, Yuquan Zhou, Lijun Zhang, Changjiang Ge, Xiantao Song
Summary: This review presents the cardioprotective effects of mesenchymal stem cell-derived exosomes and explores the underlying molecular mechanisms. It also discusses several efficient approaches for delivering exosomes to the heart in clinical applications and comments on the advantages and disadvantages of each method.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Xuyang Chen, Qi Luo
Summary: This narrative review focuses on the role of exosomes in cardiovascular diseases (CVDs) and their potential clinical applications. The specific changes in exosome cargos, such as miRNAs and proteins, are found to be associated with the occurrence and development of CVDs, making them meaningful for the diagnosis and prognosis of CVDs. Additionally, exosomes can also be utilized as drug transporters and potential therapeutic methods. Overall, exosomes are expected to serve as meaningful tools in the diagnosis, treatment, and prognosis of CVDs.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Summary: Exosomes are small membrane-bound vesicles actively secreted by cells. Research on the potential and challenges of exosomes in biological signaling in myocardial function highlights their significance in cardiac physiology and pathology, emphasizing the need for scientific innovations in isolation and characterization methodologies.
Review
Nanoscience & Nanotechnology
Zaijun Zou, Han Li, Gang Xu, Yunxiang Hu, Weiguo Zhang, Kang Tian
Summary: Exosomes, natural nanocarriers, have advantages over synthetic nanocarriers and have been widely used in disease diagnosis and treatment. Engineered exosomes have significantly improved the delivery of therapeutic agents and are extensively employed in various fields. Plant-derived exosomes, which can participate in gut flora remodeling via oral administration, are considered as an ideal platform for the treatment of intestinal diseases.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Pharmacology & Pharmacy
Zhimin Yang, Yanyu Li, Zihua Wang
Summary: Exosomes are important communication carriers between cells and can be used for disease diagnosis and treatment. MSCs-Exo, as a natural drug delivery carrier, has therapeutic effects and is increasingly used in the treatment of cardiovascular diseases and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Jieun Lee, Hal Sternberg, Paola A. Bignone, James Murai, Nafees N. Malik, Michael D. West, Dana Larocca
Summary: This study presents a panel of clonal embryonic endothelial progenitor cell lines derived from human embryonic stem cells. These cell lines exhibit characteristics of endothelial cells and show strong transcriptomic similarity to adult endothelial primary cell lines. The cells have demonstrated scalability and stable angiogenic properties, making them a potential source for therapeutic cells in cardiovascular disease treatment.
Article
Infectious Diseases
Eva Orviz, Anabel Negredo, Oskar Ayerdi, Ana Vazquez, Ana Munoz-Gomez, Sara Monzon, Petunia Clavo, Angel Zaballos, Mar Vera, Patricia Sanchez, Noemi Cabello, Pilar Jimenez, Jorge A. Perez-Garcia, Sarai Varona, Jorge del Romero, Isabel Cuesta, Alberto Delgado-Iribarren, Montse Torres, Inigo Sagastagoitia, Gustavo Palacios, Vicente Estrada, Maria Paz Sanchez-Seco
Summary: This observational study focused on monkeypox cases in Madrid, Spain, and investigated the clinical and virological aspects of the disease. The findings revealed that the virus circulating in Spain belongs to the western African clade, mainly affecting cisgender men who have sex with men (MSM). The first symptom of the disease was skin lesions, and the disease followed a self-limited course.
JOURNAL OF INFECTION
(2022)
Review
Genetics & Heredity
Jinyu Xu, Weitie Wang, Yong Wang, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu
Summary: This review discusses the role of exosomes and the biomolecules they contain in the prevention, diagnosis, and treatment of cardiovascular diseases. By examining the results of published studies, the review reveals the mechanisms of exosomal miRNAs in various cardiovascular diseases.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Ravi B. Patel, Jozine M. Ter Maaten, Joao Pedro Ferreira, Finnian R. McCausland, Sanjiv J. Shah, Patrick Rossignol, Scott D. Solomon, Muthiah Vaduganathan, Milton Packer, Aliza Thompson, Norman Stockbridge, Faiez Zannad
Summary: Patients with chronic cardiovascular or metabolic diseases often have comorbid kidney disease, leading to worse long-term outcomes. Certain novel treatments have shown beneficial effects on both cardiac and kidney outcomes, sparking interest in formally acknowledging and defining composite cardio-kidney outcomes in future cardiovascular trials.
Review
Biochemistry & Molecular Biology
Xiaoying Jiang, Ronghui Lei
Summary: Exosomes are membrane-surrounded extracellular vesicles that mediate intercellular communication by delivering bioactive molecules. Long noncoding RNAs (lncRNAs), a class of non-protein-coding RNAs, play important roles in the development of cardiovascular diseases (CVDs). In this article, we review the current studies on exosomal lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, aiming to deepen our understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Cell Biology
Xiaoyi Hu, Hongran Qin, Yi Yan, Wenhui Wu, Sugang Gong, Lan Wang, Rong Jiang, Qinhua Zhao, Yuanyuan Sun, Qian Wang, Shang Wang, Hui Zhao, Jinming Liu, Ping Yuan
Summary: This article provides a comprehensive overview of the biogenesis and functions of exosomes, circRNAs, and exosomal circRNAs, as well as their involvement in cardiovascular diseases, offering new insights into the diagnosis and treatment of these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Patrick Santos, Fausto Almeida
Summary: Extracellular vesicles play crucial roles in processes such as inflammation, cell proliferation, and immune response, while also being implicated in the pathogenesis of diseases like cancer and infectious diseases. Research suggests that EV-based vaccines have promising therapeutic potential for cancer and infectious diseases, showing exciting results in inducing immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell & Tissue Engineering
Shisi Ma, Xiao Liu, Jiayang Yin, Lili Hao, Yuyao Diao, Jingxiang Zhong
Summary: This article provides a detailed description of the potential mechanisms of exosomes and autophagy, both of which are involved in ocular surface and retinal diseases.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Chiara Gardin, Letizia Ferroni, Sara Leo, Elena Tremoli, Barbara Zavan
Summary: This review summarizes the role of platelet-derived exosomes in intercellular communication in the pathogenesis of atherosclerosis, as well as their potential as biomarkers for AS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Banafsheh Yalameha, Hamid Reza Nejabati
Summary: Increasing research over the past decade has focused on urinary exosomes (UEs) and their relationship with physiological and pathological processes. UEs are membranous vesicles containing bioactive molecules that can serve as biomarkers for early disease identification. Recent studies have isolated exosomal metabolites from urine, which can be used for discovery of biomarkers, investigation of disease mechanisms, and prediction of cardiovascular disease risk factors. Alterations in certain urinary metabolites have shown potential in predicting cardiovascular risk factors, offering a novel approach to evaluate the pathological status of cardiovascular diseases.
CLINICA CHIMICA ACTA
(2023)
Article
Biology
Zhengpeng Wan, Xiangjun Chen, Haodong Chen, Qinghua Ji, Yingjia Chen, Jing Wang, Yiyun Cao, Fei Wang, Jizhong Lou, Zhuo Tang, Wanli Liu
Article
Immunology
Liling Xu, Mengdie Xia, Jun Guo, Xiaolin Sun, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying-Hua Chen, Zhibin Hu, Zhanguo Li, Chenqi Xu, Haipeng Gong, Wanli Liu
JOURNAL OF EXPERIMENTAL MEDICINE
(2016)
Article
Multidisciplinary Sciences
Wei Yang, Yibing Bai, Ying Xiong, Jin Zhang, Shuokai Chen, Xiaojun Zheng, Xiangbo Meng, Lunyi Li, Jing Wang, Chenguang Xu, Chengsong Yan, Lijuan Wang, Catharine C. Y. Chang, Ta-Yuan Chang, Ti Zhang, Penghui Zhou, Bao-Liang Song, Wanli Liu, Shao-Cong Sun, Xiaolong Liu, Bo-liang Li, Chenqi Xu
Article
Multidisciplinary Sciences
Jing Wang, Shan Tang, Zhengpeng Wan, Yiren Gao, Yiyun Cao, Junyang Yi, Yanyan Si, Haowen Zhang, Lei Liu, Wanli Liu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Chemistry, Multidisciplinary
Shan Tang, Zhengpeng Wan, Yiren Gao, Ji-Shen Zheng, Jing Wang, Yan-Yan Si, Xin Chen, Hai Qi, Lei Liu, Wanli Liu
Article
Immunology
Yingjia Chen, Fanlei Hu, Xuejiao Dong, Meng Zhao, Jing Wang, Xiaolin Sun, Tae Jin Kim, Zhanguo Li, Wanli Liu
JOURNAL OF IMMUNOLOGY
(2017)
Article
Cell Biology
Jing Wang, Liling Xu, Samina Shaheen, Sichen Liu, Wenjie Zheng, Xiaolin Sun, Zhanguo Li, Wanli Liu
Article
Biology
Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau, Xinxin Li, Shaosen Zhang, Yang Liu, Junyang Yi, Yingyue Zeng, Jing Wang, Xiangjun Chen, Liling Xu, Wei Chen, Fei Wang, Yun Lu, Wenjie Zheng, Yan Shi, Xiaolin Sun, Zhanguo Li, Chunyang Xiong, Wanli Liu
Article
Cell Biology
Zhengpeng Wan, Chenguang Xu, Xiangjun Chen, Hengyi Xie, Zongyu Li, Jing Wang, Xingyu Ji, Haodong Chen, Qinghua Ji, Samina Shaheen, Yang Xu, Fei Wang, Zhuo Tang, Ji-Shen Zheng, Wei Chen, Jizhong Lou, Wanli Liu
JOURNAL OF CELL BIOLOGY
(2018)
Article
Immunology
Jing Wang, Sichen Liu, Baidong Hou, Meixiang Yang, Zhongjun Dong, Hai Qi, Wanli Liu
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Immunology
Chenguang Xu, Zhengpeng Wan, Samina Shaheen, Jing Wang, Zhiyong Yang, Wanli Liu
IMMUNOLOGICAL REVIEWS
(2019)
Review
Cardiac & Cardiovascular Systems
Shuqing Liu, Xinxiu Meng, Guoping Li, Priyanka Gokulnath, Jing Wang, Junjie Xiao
Summary: Exercise training plays a crucial role in maintaining cardiac homeostasis and promoting cardiac repair after myocardial infarction. This review summarizes the experimental evidence of exercise training in ventricular remodeling after myocardial infarction and provides a theoretical basis and suitable references for exercise prescription aimed at prevention and therapy.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
RuiCi Lin, Ziyue Yi, Jing Wang, Shuo Geng, Liwu Li
Summary: Neutrophils play important roles in infection and inflammation, but their contribution to inflammation resolution has been under-studied. This study identified a subpopulation of neutrophils with pro-resolving characteristics and showed that 4-PBA can train neutrophils into the resolving state with enhanced phagocytosis and bacterial-killing functions. These findings have implications for the treatment of acute infection and chronic inflammatory diseases.
CELL DEATH & DISEASE
(2022)
Review
Medicine, Research & Experimental
Jing Wang, Yi Duan, Joost P. G. Sluijter, Junjie Xiao
