Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation

SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation

(2018) Zhen-Dong Zhu et al.   Cell Death & Disease

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

(2018) Jing Liu et al.   Cell Death & Disease

TRPC6 and kidney disease: sclerosing more than just glomeruli?

(2017) Johannes Schlondorff   KIDNEY INTERNATIONAL

Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho

(2017) Yueh-Lin Wu et al.   KIDNEY INTERNATIONAL

Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries

(2017) Xiju He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Kidney Injury

(2016) Anna Zuk et al.   Annual Review of Medicine

Canonical Transient Receptor Potential 6 Channel: A New Target of Reactive Oxygen Species in Renal Physiology and Pathology

(2016) Rong Ma et al.   ANTIOXIDANTS & REDOX SIGNALING

The yin and yang of autophagy in acute kidney injury

(2016) Anette Melk et al.   Autophagy

Store-operated calcium entry-activated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure

(2016) Jie Yang et al.   Autophagy

Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition

(2016) Qian Wang et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-кB Translocation

(2016) Xiaoyun Chen et al.   MOLECULAR NEUROBIOLOGY

Autophagy and Tubular Cell Death in the Kidney

(2016) Andrea Havasi et al.   SEMINARS IN NEPHROLOGY

The role of TRPC6 in oxidative stress-induced podocyte ischemic injury

(2015) Bo Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells

(2015) Lu Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels

(2015) T Maier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy Protects Renal Tubular Cells Against Ischemia / Reperfusion Injury in a Time-Dependent Manner

(2015) Xuejing Guan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TRPC1-mediated Ca2+ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy

(2015) P Sukumaran et al.   Cell Death & Disease

α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway

(2015) M Hasanain et al.   Cell Death & Disease

Autophagy in Renal Ischemia-Reperfusion Injury: Friend or Foe?

(2014) J. P. Decuypere et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Recombinant Human Erythropoietin Pretreatment Attenuates Acute Renal Tubular Injury Against Ischemia-Reperfusion by Restoring Transient Receptor Potential Channel-6 Expression and Function in Collecting Ducts

(2014) Sai’e Shen et al.   CRITICAL CARE MEDICINE

Volatile Anesthetics and AKI: Risks, Mechanisms, and a Potential Therapeutic Window

(2014) K. Fukazawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The effects of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII

(2014) Yu Shengyou et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Revealing the Underlying Mechanism of Ischemia Reperfusion Injury Using Bioinformatics Approach

(2014) Bingbing Shen et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation

(2014) C Kao et al.   Cell Death & Disease

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

(2014) L Chang et al.   Cell Death & Disease

Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress

(2014) H He et al.   Cell Death & Disease

Modulation of intracellular calcium homeostasis blocks autophagosome formation

(2013) Nikolai Engedal et al.   Autophagy

TRPC6 Regulates CXCR2-Mediated Chemotaxis of Murine Neutrophils

(2013) O. Lindemann et al.   JOURNAL OF IMMUNOLOGY

Autophagy in Acute Kidney Injury

(2013) Man J. Livingston et al.   SEMINARS IN NEPHROLOGY

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

Regulation of store-operated calcium entry during cell division: Figure 1

(2012) Jeremy T. Smyth et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Autophagy protects proximal tubular cells from injury and apoptosis

(2012) Gur P. Kaushal   KIDNEY INTERNATIONAL

Platelet-Derived Growth Factor CC-Mediated Neuroprotection against HIV Tat Involves TRPC-Mediated Inactivation of GSK 3beta

(2012) Fuwang Peng et al.   PLoS One

Reactive Oxygen Species-mediated TRPC6 Protein Activation in Vascular Myocytes, a Mechanism for Vasoconstrictor-regulated Vascular Tone

(2011) Yanfeng Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

Pathophysiology of ischemic acute kidney injury

(2011) Asif A. Sharfuddin et al.   Nature Reviews Nephrology

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations

(2009) Lutz Birnbaumer   Annual Review of Pharmacology and Toxicology

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Participation of autophagy in renal ischemia/reperfusion injury

(2008) Chigure Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway

(2008) S. H. Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extracellular Signal-Regulated Kinase Activation Mediates Mitochondrial Dysfunction and Necrosis Induced by Hydrogen Peroxide in Renal Proximal Tubular Cells

(2008) S. Zhuang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS