Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1

The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse

(2017) Inbar Azoulay-Alfaguter et al.   Science Signaling

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse

(2017) Inbar Azoulay-Alfaguter et al.   Science Signaling

Kindlin-2 directly binds actin and regulates integrin outside-in signaling

(2016) Kamila Bledzka et al.   JOURNAL OF CELL BIOLOGY

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion

(2016) Samuel M. S. Cheung et al.   JOURNAL OF IMMUNOLOGY

LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling–Dependent Notch Pathway

(2016) Navin K. Verma et al.   JOURNAL OF IMMUNOLOGY

Between Rho(k) and a Hard Place: The Relation Between Vessel Wall Stiffness, Endothelial Contractility, and Cardiovascular Disease

(2015) S. Huveneers et al.   CIRCULATION RESEARCH

CRK proteins selectively regulate T cell migration into inflamed tissues

(2015) Yanping Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?

(2014) Navin K. Verma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

(2014) X. Zhang et al.   JOURNAL OF CELL SCIENCE

Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance

(2014) R. Martinelli et al.   JOURNAL OF CELL SCIENCE

The multiple faces of leukocyte interstitial migration

(2014) Tim Lämmermann et al.   Seminars in Immunopathology

Crk at the Quarter Century Mark: Perspectives in Signaling and Cancer

(2013) Sushil Kumar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Essential roles of Crk and CrkL in fibroblast structure and motility

(2013) T-J Park et al.   ONCOGENE

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII

(2012) Wojciech Jankowski et al.   Nature Chemical Biology

Myosin IIA Modulates T Cell Receptor Transport and CasL Phosphorylation during Early Immunological Synapse Formation

(2012) Yan Yu et al.   PLoS One

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse

(2012) Sudha Kumari et al.   Frontiers in Immunology

Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction

(2011) K. M. Stroka et al.   BLOOD

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers

(2011) Ronen Alon et al.   EXPERIMENTAL CELL RESEARCH

Talin-1 and Kindlin-3 Regulate α 4 β 1 Integrin-Mediated Adhesion Stabilization, but Not G Protein-Coupled Receptor-Induced Affinity Upregulation

(2011) Sharon J. Hyduk et al.   JOURNAL OF IMMUNOLOGY

Mapping elasticity moduli of atherosclerotic plaque in situ via atomic force microscopy

(2011) Philippe Tracqui et al.   JOURNAL OF STRUCTURAL BIOLOGY

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

(2011) J. Huynh et al.   Science Translational Medicine

Mechanisms of force generation and force transmission during interstitial leukocyte migration

(2010) Jörg Renkawitz et al.   EMBO REPORTS

The NPIY motif in the integrin  1 tail dictates the requirement for talin-1 in outside-in signaling

(2010) B. Nieves et al.   JOURNAL OF CELL SCIENCE

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Lifeact mice for studying F-actin dynamics

(2010) Julia Riedl et al.   NATURE METHODS

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate

(2010) S. Beinke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration

(2009) Takuya Watanabe et al.   CELL RESEARCH

Lymphocyte Crawling and Transendothelial Migration Require Chemokine Triggering of High-Affinity LFA-1 Integrin

(2009) Ziv Shulman et al.   IMMUNITY

Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals

(2009) S. Antoku et al.   JOURNAL OF CELL SCIENCE

Myosin-IIA and ICAM-1 Regulate the Interchange between Two Distinct Modes of T Cell Migration

(2009) J. Jacobelli et al.   JOURNAL OF IMMUNOLOGY

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility

(2009) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-kinases in cell migration

(2008) Robert J. Cain et al.   BIOLOGY OF THE CELL

The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse

(2008) Y. Huang et al.   BLOOD

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1

(2008) Jeffrey C. Nolz et al.   JOURNAL OF CELL BIOLOGY

Crk and Crk-Like Play Essential Overlapping Roles Downstream of Disabled-1 in the Reelin Pathway

(2008) T.-J. Park et al.   JOURNAL OF NEUROSCIENCE