Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

Autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants

(2018) Jennifer J Johnston et al.   GENETICS IN MEDICINE

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

(2018) Zhongqi Ge et al.   Cell Reports

Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction

(2017) Hyunbum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analyzing trapped protein complexes by Virotrap and SFINX

(2017) Kevin Titeca et al.   Nature Protocols

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers

(2016) H. Jang et al.   BIOCHEMICAL JOURNAL

Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism

(2016) Yanyan Cai et al.   CANCER CELL

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

(2016) Melissa R Marzahn et al.   EMBO JOURNAL

The higher level of complexity of K-Ras4B activation at the membrane

(2016) Hyunbum Jang et al.   FASEB JOURNAL

Trapping mammalian protein complexes in viral particles

(2016) Sven Eyckerman et al.   Nature Communications

Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region

(2015) Hyunbum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rare variants inSOS2andLZTR1are associated with Noonan syndrome

(2015) Guilherme Lopes Yamamoto et al.   JOURNAL OF MEDICAL GENETICS

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants

(2014) Sonja Hutter et al.   ACTA NEUROPATHOLOGICA

Expanding the mutational spectrum of LZTR1 in schwannomatosis

(2014) Irene Paganini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mutations in LZTR1 add to the complex heterogeneity of schwannomatosis

(2014) M. J. Smith et al.   NEUROLOGY

Next-generation sequencing identifies rare variants associated with Noonan syndrome

(2014) P.-C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

(2014) Taoling Zeng et al.   Cell Reports

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

(2013) Lan K Nguyen et al.   Cell Communication and Signaling

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

(2013) Michal Simicek et al.   NATURE CELL BIOLOGY

Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas

(2013) Arkadiusz Piotrowski et al.   NATURE GENETICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Rabex-5 Ubiquitin Ligase Activity Restricts Ras Signaling to Establish Pathway Homeostasis in Drosophila

(2010) Hua Yan et al.   CURRENT BIOLOGY

Feedback Regulation of Ras Signaling by Rabex-5-Mediated Ubiquitination

(2010) Lizhong Xu et al.   CURRENT BIOLOGY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Cranial bone morphometric study among mouse strains

(2008) Minoru Kawakami et al.   BMC EVOLUTIONARY BIOLOGY

FireDock: a web server for fast interaction refinement in molecular docking

(2008) E. Mashiach et al.   NUCLEIC ACIDS RESEARCH