Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker
出版年份 2018 全文链接
标题
Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker
作者
关键词
Squamous cell carcinomas, Phosphorylation, Squamous cell lung carcinoma, Lung and intrathoracic tumors, Adenocarcinomas, Immunoblotting, Linear regression analysis, Lymph nodes
出版物
PLoS One
Volume 13, Issue 11, Pages e0207483
出版商
Public Library of Science (PLoS)
发表日期
2018-11-20
DOI
10.1371/journal.pone.0207483
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma
- (2016) Lu Chen et al. Journal of Thoracic Oncology
- Cyclin-Dependent Kinase 5 (CDK5) Controls Melanoma Cell Motility, Invasiveness, and Metastatic Spread—Identification of a Promising Novel therapeutic target
- (2015) Savita Bisht et al. Translational Oncology
- An immunohistochemical study of cyclin-dependent kinase 5 (CDK5) expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a possible prognostic biomarker
- (2015) Kanglai Wei et al. World Journal of Surgical Oncology
- The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts
- (2015) Bernadette Sosa-García et al. PLoS One
- Reproducibility of Histopathological Diagnosis in Poorly Differentiated NSCLC: An International Multiobserver Study
- (2014) Erik Thunnissen et al. Journal of Thoracic Oncology
- Impact of Non–Small-Cell Lung Cancer-Not Otherwise Specified Immunophenotyping on Treatment Outcome
- (2014) Luisella Righi et al. Journal of Thoracic Oncology
- Distinct and Site-Specific Phosphorylation of the Retinoblastoma Protein at Serine 612 in Differentiated Cells
- (2014) Takayuki Hattori et al. PLoS One
- Clinical significance of the ‘not otherwise specified’ subtype in candidates for resectable non-small cell lung cancer
- (2014) SHINYA TANE et al. Oncology Letters
- Is Immunohistochemistry Always Required to Diagnose Lung Cancer?
- (2013) Giulio Rossi et al. ADVANCES IN ANATOMIC PATHOLOGY
- Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma
- (2013) David H. Hwang et al. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
- Establishing the Diagnosis of Lung Cancer
- (2013) M. Patricia Rivera et al. CHEST
- Diagnostic Surgical Pathology in Lung Cancer
- (2013) Arnold M. Schwartz et al. CHEST
- Subtyping Non–Small Cell Lung Cancer
- (2013) Giulio Rossi et al. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
- Multiple Mechanisms for E2F Binding Inhibition by Phosphorylation of the Retinoblastoma Protein C-Terminal Domain
- (2013) Jason R. Burke et al. JOURNAL OF MOLECULAR BIOLOGY
- The retinoblastoma tumor suppressor pathway modulates the invasiveness of ErbB2-positive breast cancer
- (2013) A K Witkiewicz et al. ONCOGENE
- Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors
- (2013) B E Engel et al. Cell Death & Disease
- CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
- (2013) Qian Liang et al. Scientific Reports
- Validation of Interobserver Agreement in Lung Cancer Assessment: Hematoxylin-Eosin Diagnostic Reproducibility for Non–Small Cell Lung Cancer: The 2004 World Health Organization Classification and Therapeutically Relevant Subsets
- (2012) Juneko E. Grilley-Olson et al. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
- Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons
- (2012) Akira Futatsugi et al. CELL CYCLE
- Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition
- (2012) Brandon Lentine et al. CELL CYCLE
- New Strategies in Squamous Cell Carcinoma of the Lung: Identification of Tumor Drivers to Personalize Therapy
- (2012) K. A. Gold et al. CLINICAL CANCER RESEARCH
- Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer
- (2012) Yoshimi Arima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies
- (2012) Johannes R Kratz et al. LANCET
- Diversity within the pRb pathway: is there a code of conduct?
- (2012) S Munro et al. ONCOGENE
- Deciphering the retinoblastoma protein phosphorylation code
- (2012) Seth M. Rubin TRENDS IN BIOCHEMICAL SCIENCES
- Immunohistochemical subtyping of nonsmall cell lung cancer not otherwise specified in fine-needle aspiration cytology
- (2011) Luisella Righi et al. CANCER
- Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras
- (2011) J. P. Eggers et al. CLINICAL CANCER RESEARCH
- Utility of 10 Immunohistochemical Markers Including Novel Markers (Desmocollin-3, Glypican 3, S100A2, S100A7, and Sox-2) for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung
- (2011) Koji Tsuta et al. Journal of Thoracic Oncology
- Subtyping of Non-small Cell Lung Carcinoma: A Comparison of Small Biopsy and Cytology Specimens
- (2011) Carlie S. Sigel et al. Journal of Thoracic Oncology
- International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
- (2011) William D. Travis et al. Journal of Thoracic Oncology
- Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens
- (2011) Natasha Rekhtman et al. MODERN PATHOLOGY
- The Diagnostic Value of Cytokeratin 5/6, 14, 17, and 18 Expression in Human Non-Small Cell Lung Cancer
- (2011) Yuan Chen et al. ONCOLOGY
- FAK is involved in invasion and metastasis of hepatocellular carcinoma
- (2010) Jing-Song Chen et al. CLINICAL & EXPERIMENTAL METASTASIS
- Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis
- (2010) Jun-Li Liu et al. MEDICAL ONCOLOGY
- A Role for the Retinoblastoma Protein As a Regulator of Mouse Osteoblast Cell Adhesion: Implications for Osteogenesis and Osteosarcoma Formation
- (2010) Bernadette Sosa-García et al. PLoS One
- Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population
- (2009) Hyo Seon Choi et al. JOURNAL OF HUMAN GENETICS
- Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung
- (2009) Valentina Monica et al. MODERN PATHOLOGY
- Large Cell Carcinoma of the Lung
- (2009) Javier Pardo et al. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
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