Review
Pharmacology & Pharmacy
Zuha Imtiyaz, Jiaxi He, Qixin Leng, Atul K. Agrawal, A. James Mixson
Summary: Researchers are exploring various nanoparticle methods to deliver chemotherapeutic agents to tumors with higher accumulation. pH-dependent histidine-based nanoparticles show promising potential for treatment, but challenges remain in clinical trials.
Review
Cell Biology
Nayanthara U. Dharmaratne, Alanna R. Kaplan, Peter M. Glazer
Summary: pHLIPs offer a promising approach for targeted drug delivery to tumors based on the acidic environment of hypoxic tumors, highlighting their potential applications in cancer therapy.
Article
Biochemistry & Molecular Biology
Giovanni Tabbi, Lorena Maria Cucci, Calogero Pinzino, Alessia Munzone, Tiziano Marzo, Silvia Pizzanelli, Cristina Satriano, Antonio Magri, Diego La Mendola
Summary: The study characterized copper complex species formed with peptide fragments derived from the N-terminal domain of the angiogenin protein. The amino group was identified as the main copper anchoring site for Ang1-17, with different coordination environments affecting the peptides' activity. Additionally, different protein isoforms showed varying effects on cellular copper uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Federica Vurro, Ylenia Jabalera, Silvia Mannucci, Giulia Glorani, Alberto Sola-Leyva, Marco Gerosa, Alessandro Romeo, Maria Grazia Romanelli, Manuela Malatesta, Laura Calderan, Guillermo R. Iglesias, Maria P. Carrasco-Jimenez, Concepcion Jimenez-Lopez, Massimiliano Perduca
Summary: MamC-expressed BMNPs have advantages in stable functionalization and molecule release, but face challenges in cell internalization. Encapsulation with PLGA and functionalization with TAT peptide enhance internalization without compromising cell viability.
Article
Instruments & Instrumentation
Ruchika Goyal, Gaurav Jerath, Aneesh Chandrasekharan, Yvonne Christian, T. R. Santhosh Kumar, Vibin Ramakrishnan
Summary: This study developed a peptide-based drug delivery unit with a tumor homing domain chemically linked to a cell-penetrating domain, showing selective toxicity to MDA-MB-231 breast cancer cells and superior penetration in three-dimensional MDA-MB-231 tumorospheres.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hamad Alrbyawi, Ishwor Poudel, Manjusha Annaji, Sai H. S. Boddu, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu
Summary: In this study, a pH-sensitive liposomal system was used to deliver daunorubicin to melanoma cells, resulting in enhanced cytotoxic effects. The liposomes exhibited high drug encapsulation efficiency and rapid release at acidic pH, leading to significantly higher cytotoxicity compared to conventional daunorubicin or liposomes.
Article
Pharmacology & Pharmacy
Jafrin Jobayer Sonju, Achyut Dahal, Sitanshu S. Singh, Xin Gu, William D. Johnson, Chandra Mohan Reddy Muthumula, Sharon A. Meyer, Seetharama D. Jois
Summary: This research focuses on the use of a pH-sensitive liposomal formulation and a targeting ligand conjugated cytotoxic drug to achieve targeted delivery of chemotherapy. The results showed promising in vitro and in vivo studies, indicating improved anticancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Prakash Lingasamy, Kristina Posnograjeva, Sergei Kopanchuk, Allan Tobi, Ago Rinken, Ignacio J. General, Eliana K. Asciutto, Tambet Teesalu
Summary: The study elucidates the binding dynamics of the PL1 peptide with its receptors, as well as the process of binding and internalization of PL1 nanoparticles in vitro. Results indicate that the engagement of PL1 peptide with FN-EDB and TNC-C is primarily driven by electrostatic interactions, and PL1-functionalized nanoparticles can deposit on the target ECM and induce cellular uptake.
Article
Biophysics
Zhongying Gong, Xiaoying Liu, Baolong Zhou, Guohui Wang, Xiuwen Guan, Ying Xu, Juanjuan Zhang, Zexin Hong, Juanjuan Cao, Xirui Sun, Zhiqin Gao, Haozheng Lu, Xingliang Pan, Jingkun Bai
Summary: This study developed a strategy using peptide nanoparticles to release drugs in the acidic microenvironment of tumors, enhancing the effectiveness of anti-tumor drugs through targeted delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Hang Yang, Yan Luo, Hang Hu, Sibo Yang, Yanan Li, Huijuan Jin, Shengcai Chen, Quanwei He, Candong Hong, Jiehong Wu, Yan Wan, Man Li, Zifu Li, Xiangliang Yang, Ying Su, Yifan Zhou, Bo Hu
Summary: This study introduces a dual-targeted therapeutic strategy for improving drug delivery in ischemic brain, utilizing PHSRN peptides for targeted delivery and SAG@PHSRN-HES nanoparticles to release more SAG in the acidic environment of ischemic brain tissue. The synergistic mechanisms of PHSRN and SAG hold promise in promoting angiogenesis and improving neurological function recovery, suggesting potential for treating cerebral infarction patients.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Analytical
Tao Zhang, Fangjun Huo, Weijie Zhang, Jianbin Chao, Caixia Yin
Summary: The acidity of lysosome is crucial for its physiological activities, with abnormal pH fluctuations leading to diseases. SN-Lyso, a new ratiometric fluorescent probe, can detect pH fluctuations of lysosomes and has been successfully used in fluorescence imaging of living cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
William M. MacCuaig, Benjamin L. Fouts, Molly W. McNally, William E. Grizzle, Phillip Chuong, Abhilash Samykutty, Priyabrata Mukherjee, Min Li, Jacek B. Jasinski, Bahareh Behkam, Lacey R. McNally
Summary: Active targeting using V7 peptide is superior to nanoparticle size in tumor uptake, with size having a secondary effect on actively targeted nanoparticles. Passive targeting nanoparticles showed no significant effect of size on uptake.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Yonghee Shin, Keumrai Whang, Jeong Ha Hwang, Yuseung Jo, Jeong-Woo Choi, Junhee Park, Inhee Choi, Taewook Kang
Summary: By using near-infrared Raman technique, the dynamics of CO release from CORMs was successfully investigated, showing that the release rate of CO is significantly influenced by pH and temperature.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Li Zhang, Jiyan Huang, Mixue Chen, Hongmei Huang, Yi Xiao, Ronghua Yang, Youyu Zhang, Xiaoxiao He, Kemin Wang
Summary: An anionic dipyridyl tetraphenylethene (TPE) derivative was designed to construct a super-small self-assembled AIEgen nanoprobe (TPE-2Py-SO(3)NaNPs, ca. 2.48 nm) for the supersensitive detection of protamine and trypsin.
ANALYTICAL METHODS
(2023)
Article
Engineering, Biomedical
Wen Hu, Lipeng Qiu, Liang Cheng, Qing Hu, Yang Liu, Ziyang Hu, Dawei Chen, Lifang Cheng
ACTA BIOMATERIALIA
(2016)
Article
Materials Science, Biomaterials
Lipeng Qiu, Mengqin Zhu, Kai Gong, Huanhuan Peng, Lu Ge, Li Zhao, Jinghua Chen
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Materials Science, Multidisciplinary
Huijie Zhang, Mengxia Peng, Ting Cheng, Peng Zhao, Lipeng Qiu, Juan Zhou, Guozhong Lu, Jinghua Chen
JOURNAL OF MATERIALS SCIENCE
(2018)
Article
Materials Science, Biomaterials
Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu, Jinghua Chen
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Chemistry, Medicinal
Kamel S. Ahmed, Shenhuan Liu, Jing Mao, Jie Zhang, Lipeng Qiu
Summary: The study developed a multifunctional nano-structured liposomal system for co-delivery of doxorubicin and celecoxib to overcome doxorubicin resistance in breast cancer, showing remarkable treatment efficacy. The peptide-modified targeted liposomes exhibited strong cellular entry ability and mitochondrial-targeting effect, effectively inhibiting P-glycoprotein efflux activity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Yang Yang, Fuwei Yang, Xiaotian Shan, Jiamin Xu, Wenjie Fang, Juan Zhou, Lipeng Qiu, Jinghua Chen
Summary: The pH/reduction dual sensitive PCT polymers have been synthesized to promote rapid release of drug-loaded micelles at tumor site, showing strong cytotoxicity against tumor cells and better inhibitory effect on tumor growth compared to control micelles. The PCT micelles can be depolymerized in intracellular acidic and reductive environment to release drugs rapidly, indicating great potential for intercellular delivery of antitumor drugs.
Article
Nanoscience & Nanotechnology
Huijie Zhang, Airan Ding, Baoting Ye, Zhiqing Wang, Jiawen Zhang, Lipeng Qiu, Jinghua Chen
Summary: This study developed a multifunctional CpG ODN delivery system utilizing GCNNs and CS, which showed no cytotoxicity and efficient CpG ODN loading. CS-GCNNs significantly increased CpG ODN uptake in cells and triggered enhanced immunostimulation, with the added ability to stably trace the delivery process through cell imaging.
ACS APPLIED NANO MATERIALS
(2021)
Article
Engineering, Biomedical
Lipeng Qiu, Jiamin Xu, Kamel S. S. Ahmed, Mengqin Zhu, Yan Zhang, Miaomiao Long, Weijun Chen, Wenjie Fang, Huijie Zhang, Jinghua Chen
Summary: A dual-functional pH-sensitive drug delivery system was developed for breast cancer therapy. The system showed higher cytotoxicity and cell uptake efficiency compared to other drug-loaded micelles, indicating its potential for reversing multidrug resistance. In vivo experiments demonstrated that the system effectively inhibited tumor growth without significant changes in body weight. The results suggest that the dual gain DNVM can enhance the efficacy of chemotherapy for doxorubicin-resistant tumor cells and has the potential to overcome multiple drug resistance.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Meiyang Yang, Mariana Conceicao, Weijun Chen, Fuwei Yang, Bingke Zhao, Matthew J. A. Wood, Lipeng Qiu, Jinghua Chen
Summary: The development of an engineered bacteria delivery system that can distribute throughout the entire tumor and suppress metastasis is of great significance in cancer treatment improvement.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Wei Jun Chen, Dhanu Gupta, Meiyang Yang, Fuwei Yang, Ning Feng, Junling Song, Matthew J. A. Wood, Lipeng Qiu, Jinghua Chen
Summary: Metal-organic frameworks (MOFs) with tunable porosity, biocompatibility, and modularity have shown promise as novel therapeutics for malignancies. However, the design and synthesis of dual-stimuli responsive MOFs for controlled drug release in tumor microenvironments are challenging. This study synthesized pH/glutathione (GSH)-sensitive MnFe-based MOFs combined with gold nanoparticles (Au NPs) and cisplatin prodrugs (DSCP) for chemo-chemodynamic-starvation synergistic therapy.
Article
Engineering, Biomedical
Weijun Chen, Meiyang Yang, Jie Li, Zhilan Chen, Lefei Hu, Jiannan Zhang, Liangyu Cai, Lipeng Qiu, Jinghua Chen
Summary: A novel GSH-activatable Cu2+-Quercetin network loaded with Au nanoparticles and DOX was synthesized for the synergistic therapy of chemotherapy enhanced by chemotherapy and photothermal therapy. The multi-mode synergistic strategy showed excellent therapeutic effects in cancer cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Qingfeng Guo, Jie Li, Jing Mao, Weijun Chen, Meiyang Yang, Yang Yang, Yuming Hua, Lipeng Qiu, Dennis Douroumis, Alexander K. Andrianov
Summary: A multifunctional delivery system was prepared to reverse tumor multidrug resistance (MDR) by inhibiting drug efflux and autophagy. The system effectively inhibited drug efflux and autophagy, leading to enhanced therapeutic effects. In vitro and in vivo experiments demonstrated that the delivery system effectively inhibited tumor growth and induced death of drug-resistant cells.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Materials Science, Biomaterials
Meiyang Yang, Fuwei Yang, Weijun Chen, Shenhuan Liu, Lipeng Qiu, Jinghua Chen
Summary: Cancer therapy utilizing live tumor-targeting bacteria offers unique advantages, but the lack of understanding on mechanisms and side effects presents challenges in developing such microbial treatments.
BIOMATERIALS SCIENCE
(2021)
Correction
Engineering, Biomedical
Wen Hu, Lipeng Qiu, Liang Cheng, Qing Hu, Yang Liu, Ziyang Hu, Dawei Chen, Lifang Cheng
ACTA BIOMATERIALIA
(2017)