DNA double-strand break repair: a tale of pathway choices

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

(2016) Haoxing Zhang et al.   Nature Communications

Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle

(2015) Audesh Bhat et al.   CELL CYCLE

REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination

(2015) J. E. Sale   EMBO JOURNAL

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

(2015) S. Badie et al.   EMBO JOURNAL

Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation

(2015) N. L. Batenburg et al.   EMBO JOURNAL

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

Unifying the DNA End-processing Roles of the Artemis Nuclease

(2015) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin

(2015) Wendy J. Cannan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

(2015) Ismail Hassan Ismail et al.   NATURE CELL BIOLOGY

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ

(2015) Junya Tomida et al.   NUCLEIC ACIDS RESEARCH

DNA double-strand break repair pathway choice and cancer

(2014) Tomas Aparicio et al.   DNA REPAIR

PTIP associates with Artemis to dictate DNA repair pathway choice

(2014) Jiadong Wang et al.   GENES & DEVELOPMENT

Nuclear position dictates DNA repair pathway choice

(2014) Charlène Lemaître et al.   GENES & DEVELOPMENT

Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity

(2014) Sicong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UbcH7 regulates 53BP1 stability and DSB repair

(2014) Xiangzi Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination-Mediated DNA Repair

(2014) Y. Hu et al.   Cancer Discovery

Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double-Strand Breaks Regulate 53BP1 Nucleation and NHEJ-Directed Repair

(2014) Creighton T. Tuzon et al.   Cell Reports

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice

(2014) Arun Gupta et al.   Cell Reports

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

(2014) Sílvia Carvalho et al.   eLife

Initiation of Meiotic Recombination: How and Where? Conservation and Specificities Among Eukaryotes

(2013) Bernard de Massy   Annual Review of Genetics

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset

(2013) Tamar Listovsky et al.   JOURNAL OF CELL BIOLOGY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

Mutations Arising During Repair of Chromosome Breaks

(2012) Anna Malkova et al.   Annual Review of Genetics

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Mating-Type Genes and MAT Switching in Saccharomyces cerevisiae

(2012) J. E. Haber   GENETICS

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

(2012) Maria Poulsen et al.   JOURNAL OF CELL BIOLOGY

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

Tandem Protein Interaction Modules Organize the Ubiquitin-Dependent Response to DNA Double-Strand Breaks

(2012) Stephanie Panier et al.   MOLECULAR CELL

Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

(2012) Ketki Karanam et al.   MOLECULAR CELL

Factors determining DNA double-strand break repair pathway choice in G2 phase

(2011) Atsushi Shibata et al.   EMBO JOURNAL

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

PARP inhibition in BRCA-mutated breast and ovarian cancers

(2010) Stephen L Chan et al.   LANCET

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

(2010) S. Fnu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

(2009) Yingli Sun et al.   NATURE CELL BIOLOGY

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL