Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab

Pro-metastatic activity of AGR2 interrupts angiogenesis target bevacizumab efficiency via direct interaction with VEGFA and activation of NF-κB pathway

(2018) Mengqi Jia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB

(2017) Yun-Yun Guo et al.   JOURNAL OF NEUROSCIENCE

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization

(2017) H Guo et al.   ONCOGENE

The recognition of ubiquitinated proteins by the proteasome

(2016) Guinevere L. Grice et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of Selective Autophagy in Normal Physiology and Cancer

(2016) Joseph D. Mancias et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Expression of zebrafish anterior gradient 2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10

(2014) Chih-Hao Tang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression

(2014) Zhengzhao Liu et al.   CANCER CELL

Solution Structure of the Ubiquitin-associated (UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin

(2014) Erik Walinda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

Anterior gradient 2and3- two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells

(2013) Huajie Bu et al.   FEBS Journal

Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myeloma

(2012) Darrell White et al.   CANCER

Knockdown of AGR2 induces cellular senescence in prostate cancer cells

(2012) Zhongyi Hu et al.   CARCINOGENESIS

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2

(2012) S. Li et al.   DEVELOPMENT

Smurf1 Protein Negatively Regulates Interferon-γ Signaling through Promoting STAT1 Protein Ubiquitination and Degradation

(2012) Chao Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase-I/II Study of Bortezomib in Combination with Carboplatin and Bevacizumab as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer

(2012) Bilal Piperdi et al.   Journal of Thoracic Oncology

Proteomic study explores AGR2 as pro-metastatic protein in HCC

(2012) Hongxiu Yu et al.   Molecular BioSystems

Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development

(2012) E Chevet et al.   ONCOGENE

AGR2 Is a Novel Surface Antigen That Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D

(2011) L. Dumartin et al.   CANCER RESEARCH

Inhibition of NF-κB by MG132 through ER stress-mediated induction of LAP and LIP

(2011) Shotaro Nakajima et al.   FEBS LETTERS

Role of Pro-oncogenic Protein Disulfide Isomerase (PDI) Family Member Anterior Gradient 2 (AGR2) in the Control of Endoplasmic Reticulum Homeostasis

(2011) Arisa Higa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Adenocarcinoma-associated Gene,AGR2, Induces Expression ofAmphiregulinthrough Hippo Pathway Co-activatorYAP1Activation

(2011) Aiwen Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Data-independent Proteomic Screen Identifies Novel Tamoxifen Agonist that Mediates Drug Resistance

(2011) Shawna Mae Hengel et al.   JOURNAL OF PROTEOME RESEARCH

ARRB1-Mediated Regulation of E2F Target Genes in Nicotine-Induced Growth of Lung Tumors

(2011) Piyali Dasgupta et al.   JNCI-Journal of the National Cancer Institute

Processing of autophagic protein LC3 by the 20S proteasome

(2010) Zhonghua Gao et al.   Autophagy

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers

(2010) R Hrstka et al.   ONCOGENE

Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells

(2009) Peng-fei Ge et al.   ACTA PHARMACOLOGICA SINICA

Identification of Candidate Biomarkers of Therapeutic Response to Docetaxel by Proteomic Profiling

(2009) L. Zhao et al.   CANCER RESEARCH

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover

(2009) Sarah Waters et al.   FEBS LETTERS

Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells

(2008) William Ka Kei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY