Article
Cell Biology
Dianwen Han, Lijuan Wang, Bing Chen, Wenjing Zhao, Yiran Liang, Yaming Li, Hanwen Zhang, Ying Liu, Xiaolong Wang, Tong Chen, Chen Li, Xiaojin Song, Dan Luo, Zheng Li, Qifeng Yang
Summary: The study revealed that the USP1/WDR48 complex can enhance TGF-beta-induced EMT and migration in TNBC cells by stabilizing TAK1 in vitro.
Article
Oncology
Yu Liu, Mingxu Da
Summary: This study found that WTAP is significantly overexpressed in gastric carcinoma tissue, and its high expression is closely associated with poor prognosis in gastric cancer patients. Overexpression of WTAP can promote migration and EMT of GC cells, as well as the expression of TGF-beta and mRNA stability. Knockdown of WTAP inhibits migration of GC cells, decreases TGF-beta expression, and reduces mRNA stability. In addition, WTAP also promotes multiple chemotherapy and radiotherapy resistance in GC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Xuecong Wang, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Summary: TGF-beta signaling regulates embryonic development, wound-healing, and immune homeostasis, but it is altered during tumor progression, leading to enhanced epithelial cell plasticity and a reprogramming of epithelial cells into mesenchymal lineages through EMT. This contributes to increased carcinoma cell invasion, metastasis, and immune evasion.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Oncology
Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Summary: Recent studies have shown that MICAL2 plays a role in promoting proliferation and migration of glioblastoma through the TGF-beta/p-Smad2/EMT-like signaling pathway. Knockdown of MICAL2 can inhibit the growth and invasion abilities of glioblastoma cells. High MICAL2 expression predicts poor prognosis in GBM patients, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hongyi Li, Shaojie Wang, Xiubo Li, Yongjia Weng, Dinghe Guo, Pengzhou Kong, Caixia Cheng, Yanqiang Wang, Ling Zhang, Xiaolong Cheng, Yongping Cui
Summary: CDCA7 overexpression promotes the metastasis and invasion of ESCC cell lines and is associated with the expression of EMT-related markers and the TGF-beta signaling pathway. CDCA7 plays a crucial role in EMT by regulating the expression of Smad4 and Smad7 in the TGF-beta signaling pathway.
Article
Pharmacology & Pharmacy
Fangfang Cai, Huangru Xu, Daolong Zha, Xiaoyang Wang, Ping Li, Shihui Yu, Yingying Yao, Xiaoyao Chang, Jia Chen, Yanyan Lu, Zi-Chun Hua, Hongqin Zhuang
Summary: AK2 regulates tumor cell metastasis in lung adenocarcinoma, with its high expression associated with poor patient survival; AK2 is closely related to the migration and invasion ability of lung adenocarcinoma cells; AK2 may regulate epithelial-mesenchymal transition through Smad-related signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhanjun Chen, Leyang Xiang, Longhai Li, Huohui Ou, Yinghao Fang, Yuyan Xu, Qin Liu, Zhigang Hu, Yu Huang, Xianghong Li, Dinghua Yang
Summary: The study revealed that linc00261 suppressed EMT and stem-like traits in HCC cells by inhibiting TGF-beta1/SMAD3 signaling.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Li Wei, Naiyuan Shao, Ya Peng, Peng Zhou
Summary: The study revealed a correlation between high CTSS expression and glioma tissue grades, with CTSS inhibitor ZFL attenuating TGF-beta-induced invasive growth. Inhibition of CTSS reversed TGF-beta-induced epithelial-to-mesenchymal transition and restored the turnover of tight junction proteins, leading to decreased mobility of glioblastoma cells. Furthermore, the PI3K/AKT/mTOR pathway was found to be suppressed in the TGF-beta+ZFL groups, highlighting its importance in this process.
Article
Oncology
Qingjie Kang, Xudong Peng, Xiangshu Li, Denghua Hu, Guangxu Wen, Zhengqiang Wei, Baohong Yuan
Summary: The study reveals that ORAI1 mediates TGF-beta-induced EMT in colorectal cancer cells by promoting Ca2+ entry and calpain activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shengjie Wang, Xin Tong, Chang Li, Ersuo Jin, Zhiyue Su, Zelong Sun, Weiwei Zhang, Zhe Lei, Hong-Tao Zhang
Summary: QKI-5 is significantly decreased in metastatic lung adenocarcinoma, and its overexpression inhibits TGF-beta-induced EMT and invasion. KLF6 positively regulates QKI-5 at the transcriptional level, which is associated with TGF beta R1. Targeting the KLF6/QKI-5/TGF beta R1 axis may be a promising strategy for treating LUAD.
Review
Oncology
Jun Ho Lee, Joan Massague
Summary: TGF-beta plays a crucial role in development, wound healing, fibrosis, and cancer by inducing epithelial-mesenchymal transitions (EMTs). EMTs are regulated by multiple signaling inputs, with RAS-MAPK signaling frequently required for EMT induction by TGF-beta. Recent studies have revealed the molecular basis for the cooperation between the TGF-beta-SMAD and RAS-MAPK pathways in EMT induction, offering insights into EMT and progenitor cell differentiation during gastrulation and cancer metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Yi Huang, Jenq-Lin Yang, Jih-Jung Chen, Shun-Ban Tai, Yu-Hsuan Yeh, Pei-Feng Liu, Ming-Wei Lin, Chih-Ling Chung, Chun-Lin Chen
Summary: The study showed that FQs inhibit MMP-9 expression in cancer cells, leading to a decrease in cell migration and invasion, demonstrating their potential value in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chenglai Dong, Kaiqin Wu, Shaorui Gu, Wenli Wang, Shiliang Xie, Yongxin Zhou
Summary: The study revealed the critical role of PTBP3 in LUAD, with its high expression associated with poor prognosis. PTBP3 mediates TGF-beta-induced EMT and metastasis by activating the Smad pathway for transcription. This research provides a new potential therapeutic target for the treatment of LUAD.
Article
Cell Biology
Xinyu Shao, Yibin Sun, Kaiqiang Zhong, Jinrong Gu, Yang Yu, Tong Hu, Xiaoyi Kuai, Yechen Xing
Summary: This study finds that TYRO3 is aberrantly increased in colorectal cancer tissues and is associated with prognosis. A prediction model for prognosis is constructed based on TYRO3 expression, indicating its crucial role. Knockdown of TYRO3 inhibits proliferation, migration, and drug resistance in CRC cells, which is confirmed by in vivo experiments. Furthermore, TYRO3 inhibits EMT by down-regulating ENO1, which provides a theoretical basis for TYRO3 in drug-resistance and highlights a new strategy for CRC-targeted therapy.
Article
Biochemistry & Molecular Biology
Zelong Sun, Zhiyue Su, Zhengyu Zhou, Shengjie Wang, Zhao Wang, Xin Tong, Chang Li, Yuxin Wang, Xiaoyan Chen, Zhe Lei, Hong-Tao Zhang
Summary: ALKBH5 plays a key role in regulating TGF-beta/SMAD signaling and controlling TGF-beta-induced EMT in NSCLCs. ALKBH5 expression is significantly reduced in metastatic NSCLC and its overexpression inhibits TGF-beta-induced EMT and invasion of NSCLC cells. ALKBH5 affects the expression and mRNA stability of TGF beta R2, SMAD3, and SMAD6 by erasing m(6)A modification in NSCLC cells, and interacts with m(6)A-binding proteins to further regulate TGF-beta signaling.
Review
Cell Biology
Ying E. Zhang
CURRENT OPINION IN CELL BIOLOGY
(2018)
Article
Immunology
Eric Tu, Cheryl P. Z. Chia, Weiwei Chen, Dunfang Zhang, Sang A. Park, Wenwen Jin, Dandan Wang, Maria-Luisa Alegre, Ying E. Zhang, Lingyun Sun, WanJun Chen
Article
Biochemistry & Molecular Biology
Yi Tang, Liu-Ya Tang, Xuan Xu, Cuiling Li, Chuxia Deng, Ying E. Zhang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Kun Zhu, Yi Tang, Xuan Xu, Hien Dang, Liu-Ya Tang, Xiang Wang, Xin Wei Wang, Ying E. Zhang
Article
Multidisciplinary Sciences
Erine H. Budi, Steven Hoffman, Shaojian Gao, Ying E. Zhang, Rik Derynck
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Frank Stappenbeck, Feng Wang, Liu-Ya Tang, Ying E. Zhang, Farhad Parhami
Article
Cell Biology
Ji-Hyeon Lee, Jose Manuel Mellado-Gil, Young Jae Bahn, Sushrut M. Pathy, Ying E. Zhang, Sushil G. Rane
CELL DEATH & DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Miao Yu, Xiaoyan Shi, Mengmeng Ren, Lu Liu, Hao Qi, Chi Zhang, Junhua Zou, Xiaoyan Qiu, Wei-Guo Zhu, Ying E. Zhang, Wengong Wang, Jianyuan Luo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Liu-Ya Tang, Adam Thomas, Ming Zhou, Ying E. Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Review
Cell Biology
Christina H. Stuelten, Ying E. Zhang
Summary: TGF-beta plays a dual role in tumors, acting as an inhibitor of early-stage tumorigenesis while promoting late-stage tumor progression and metastasis. Through its ability to alter cell differentiation, TGF-beta induces transitions of various cell types, contributing to the progression of epithelial tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Feng Wang, Frank Stappenbeck, Liu-Ya Tang, Ying E. Zhang, Simon T. Hui, Aldons J. Lusis, Farhad Parhami
Summary: Inflammatory responses are crucial for protecting against infections and maintaining health. Many diseases involve chronic inflammation, but current anti-inflammatory drugs often have adverse effects for long-term use. Therefore, the development of effective and non-toxic anti-inflammatory drugs is important. A semi-synthetic oxysterol called Oxy210 and its analogs have been found to exhibit anti-inflammatory effects in both animal models and cell experiments, making them potential candidates for future therapeutic development against inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Liu-Ya Tang, Marie Spezia, Ting Chen, Jee-Hye Shin, Feng Wang, Frank Stappenbeck, Andres M. Lebensohn, Farhad Parhami, Ying E. Zhang
Summary: The study revealed that oxysterols Oxy186 and Oxy210 can inhibit proliferation of NSCLC cells, with Oxy186 exhibiting potent inhibition of tumor growth. The mechanism of action involves inhibiting the WNT/beta-catenin signaling pathway.
CELL AND BIOSCIENCE
(2022)
Article
Pathology
Christina H. Stuelten, Nicolas Melis, Bhagawat Subramanian, Yi Tang, Megan Kimicata, John P. Fisher, Roberto Weigert, Ying E. Zhang
Summary: This study found that Smurf2 plays an important role in cutaneous wound healing. Loss of Smurf2 exacerbates early inflammation in the wounds and leads to narrower wounds but with greater breaking strength. In addition, loss of Smurf2 also increases the linearization of collagen bundles in normal and wounded skin.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Sang-A Park, Yun-Ji Lim, Wai Lim Ku, Dunfang Zhang, Kairong Cui, Liu-Ya Tang, Cheryl Chia, Peter Zanvit, Zuojia Chen, Wenwen Jin, Dandan Wang, Junji Xu, Ousheng Liu, Fu Wang, Alexander Cain, Nancy Guo, Hiroko Nakatsukasa, Chuan Wu, Ying E. Zhang, Keji Zhao, WanJun Chen
Summary: This study reveals that the differentiation of IL-9-producing Th9 cells is regulated by TGF-beta and IL-4 signals through pSmad3L-Ser(213), and the transcription factors DBP and E2F8 have opposing effects on Il9 gene transcription.
NATURE COMMUNICATIONS
(2022)