期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.764727
关键词
TGF-beta; tumor-stromal crosstalk; cancer associated fibroblast (CAF); EMT-epithelial to mesenchymal transition; EndMT-endothelial to mesenchymal transition; tolerogenic differentiation; metabolic reprogramming
资金
- intramural program of the US National Institutes of Health, National Cancer Institute, Center for Cancer Research
TGF-beta plays a dual role in tumors, acting as an inhibitor of early-stage tumorigenesis while promoting late-stage tumor progression and metastasis. Through its ability to alter cell differentiation, TGF-beta induces transitions of various cell types, contributing to the progression of epithelial tumors.
Transforming Growth Factor-beta (TGF-beta) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-beta is a potent inhibitor of early stage tumorigenesis and promotes late stage tumor progression and metastasis. Here, we review the roles of TGF-beta as well as components of its signaling pathways in tumorigenesis. We will discuss how a core property of TGF-beta, namely its ability to change cell differentiation, leads to the transition of epithelial cells, endothelial cells and fibroblasts to a myofibroblastoid phenotype, changes differentiation and polarization of immune cells, and induces metabolic reprogramming of cells, all of which contribute to the progression of epithelial tumors.
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