Article
Surgery
Aruchuna Ruban, Alexander D. Miras, Michael A. Glaysher, Anthony P. Goldstone, Christina G. Prechtl, Nicholas Johnson, Navpreet Chhina, Werd Al-Najim, Madhawi Aldhwayan, Natalia Klimowska-Nassar, Claire Smith, Joanne Lord, Jia V. Li, Lilliam Flores, Moaz Al-Lababidi, Georgios K. Dimitriadis, Mayank Patel, Michael Moore, Harvinder Chahal, Ahmed R. Ahmed, Jonathan Cousins, Ghadah Aldubaikhi, Ben Glover, Emanuela Falaschetti, Hutan Ashrafian, Carel W. Le Roux, Ara Darzi, James P. Byrne, Julian P. Teare
Summary: This study examined the clinical efficacy and safety of the duodenal-jejunal bypass liner (DJBL) in situ for 12 months and for 12 months after explantation. The results showed that adding DJBL to intensive medical care led to superior weight loss, improvements in cardiometabolic risk factors, and markers of fatty liver disease, but had no significant impact on glycemia. However, there were more adverse events associated with the use of DJBL.
Review
Endocrinology & Metabolism
Ji-Hua Chen, Zi-Han Yu, Qin-Ling Fei Liu, Qing-Guo Meng, Xin Chen
Summary: With the development of the economy and improvement of people's living standards, the incidence of obesity and type 2 diabetes mellitus (T2DM) has significantly increased, with obesity also becoming one of the most important risk factors of T2DM. DJBL, which mimics RYGB, has been proven to play a key role in weight loss and control of T2DM, offering a reversible, less invasive treatment option.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Surgery
Rebecca L. Paszkiewicz, Miguel A. Burch, Isaac Asare Bediako, Hasmik Mkrtchyan, Francesca Piccinini, Marilyn Ader, Catherine Bresee, Richard N. Bergman
Summary: This study assessed the effects of duodenal exclusion on glucose homeostasis using a DJBL in a nonobese canine model. The results showed that duodenal exclusion induced weight loss and negative metabolic effects, which were reversed upon re-exposure to nutrients.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Anna Obermayer, Norbert J. Tripolt, Faisal Aziz, Christoph Hogenauer, Felix Aberer, Florian Schreiber, Andreas Eherer, Caren Sourij, Vanessa Stadlbauer, Eva Svehlikova, Martina Brunner, Nandu Goswami, Harald Kojzar, Peter N. Pferschy, Thomas R. Pieber, Harald Sourij
Summary: The study showed that EndoBarrier (TM) had significant effects on weight loss, reduction of fat mass, and improvement of insulin sensitivity, which remained after the removal of the device.
Article
Nutrition & Dietetics
Michael A. Glaysher, James Ward, Madhawi Aldhwayan, Aruchuna Ruban, Christina Gabriele Prechtl, Helena L. Fisk, Navpreet Chhina, Werd Al-Najim, Claire Smith, Natalia Klimowska-Nassar, Nicholas Johnson, Emmanuela Falaschetti, Anthony P. Goldstone, Alexander Dimitri Miras, James P. Byrne, Philip C. Calder, Julian P. Teare
Summary: DJBL therapy results in superior weight loss and reductions in blood lipid levels, but also leads to depletion of essential fatty acids and their derivatives. It may be necessary to maintain adequate dietary intake or supplement with polyunsaturated fatty acids during the therapy.
CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Shohei Okikawa, Hideya Kashihara, Mitsuo Shimada, Kozo Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Yuma Wada, Toshiaki Yoshimoto
Summary: Metabolic surgery, specifically duodenal-jejunal bypass (DJB), is effective in improving glucose tolerance in the early postoperative period for non-obese rats with type 2 diabetes mellitus (T2DM). This improvement is associated with changes in glucose transporter expression, with high levels of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1), and low levels of GLUT2 in the alimentary limb (AL) of DJB-operated rats.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Steffane McLennan, Kevin Verhoeff, Kieran Purich, Jerry Dang, Janice Y. Kung, Valentin Mocanu
Summary: This systematic review and meta-analysis finds that duodenal-jejunal bypass liners (DJBLs) provide significant improvements in metabolic and anthropometric outcomes for patients with obesity. However, uncertainty about the long-term effects after device removal may limit their use as a standalone treatment for obesity and associated metabolic complications.
Article
Nutrition & Dietetics
Natascha Roehlen, Katharina Laubner, Leonard Nicolaus, Henning Schwacha, Dominik Bettinger, Andreas Krebs, Robert Thimme, Jochen Seufert
Summary: This study demonstrates significant effects of DJBL treatment on biochemical and clinical markers of NAFLD activity. DJBL therapy can reduce fatty liver index, alanine aminotransferase, and cytokeratin-18 fragments levels. Furthermore, DJBL implantation can decrease NAFLD fibrosis and APRI scores.
Article
Multidisciplinary Sciences
Jean-Michel Gonzalez, Sohaib Ouazzani, Stephane Berdah, Nicolas Cauche, Cecilia Delattre, Joyce A. Peetermans, Agostina Santoro-Schulte, Ornela Gjata, Marc Barthet
Summary: This study assessed a new natural orifice transluminal endoscopic surgery (NOTES) bariatric endoscopic procedure in obese adult pigs. The results showed weight loss in the test animals but also raised safety concerns.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Lun Wang, Zeyu Wang, Yang Yu, Zhaoheng Ren, Yongheng Jia, Jinfa Wang, Shixing Li, Tao Jiang
Summary: SADI-S surgery significantly reduces blood glucose levels and body weight in rats with T2DM models. The procedure improves T2DM by regulating phenylalanine biosynthesis, branched-chain amino acid, and lipid metabolism pathways.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Thomas Karlas, David Petroff, Juergen Feisthammel, Sebastian Beer, Matthias Blueher, Tatjana Schuetz, Ralf Lichtinghagen, Albrecht Hoffmeister, Johannes Wiegand
Summary: The study found that one year of DJBL therapy is associated with significant improvements in non-invasive markers of steatosis and NASH, but not fibrosis, and is accompanied by a substantial number of complications.
Review
Surgery
Erika Yuki Yvamoto, Diogo Turiani Hourneaux de Moura, Igor Mendonca Proenca, Epifanio Silvino do Monte Junior, Igor Braga Ribeiro, Pedro Henrique Boraschi Vieira Ribas, Matheus Candido Hemerly, Victor Lira de Oliveira, Sergio A. Sanchez-Luna, Wanderley Marques Bernardo, Eduardo Guimaraes Hourneaux de Moura
Summary: This study evaluated the effectiveness and safety of duodenal-jejunal bypass liner (DJBL). The results showed that DJBL can effectively reduce excess weight and have a positive effect on blood glucose control. However, there is a certain occurrence rate of side effects, so cautious use is needed.
Article
Endocrinology & Metabolism
D. Moriconi, M. L. Manca, M. Anselmino, E. Rebelos, R. Bellini, S. Taddei, E. Ferrannini, M. Nannipieri
Summary: This study assessed the impact of bariatric surgery on remission and relapse of type 2 diabetes mellitus (T2DM) and analyzed predictive factors. The results showed that bariatric surgery significantly improved BMI, fasting glucose, and haemoglobin A1c (HbA1c). The remission rates at 1 and 10 years post-surgery were 74% and 53% respectively. T2DM duration, baseline HbA1c, and ensuing insulin therapy were identified as the strongest predictors of remission. Short T2DM duration and good glycemic control before surgery were essential for long-lasting remission, while weight loss did not impact the long-term relapse of T2DM.
DIABETES & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Hai-Feng Han, Shao-Zhuang Liu, Xiang Zhang, Meng Wei, Xin Huang, Wen-Bin Yu
Summary: This study aimed to investigate the effects of duodenal-jejunal bypass (DJB) surgery on duodenal SIRT1 expression and the potential links between bile acids (BAs) and SIRT1. The results showed that DJB surgery increased intra-duodenal BA levels and activated the duodenal BA signaling pathway, leading to upregulation of duodenal SIRT1 expression and improved glucose homeostasis after DJB.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Madhawi M. Aldhwayan, Werd Al-Najim, Aruchuna Ruban, Michael Alan Glaysher, Brett Johnson, Navpreet Chhina, Georgios K. Dimitriadis, Christina Gabriele Prechtl, Nicholas A. Johnson, James Patrick Byrne, Anthony Peter Goldstone, Julian P. Teare, Carel W. Le Roux, Alexander Dimitri Miras
Summary: This study used the Endobarrier as a research tool to investigate the effects of lifestyle modification with or without Endobarrier insertion in obese patients with T2DM. The results showed that the superior weight loss observed in patients who underwent Endobarrier insertion was not due to a reduction in energy intake or changes in food preferences.