期刊
BIOMOLECULES
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/biom11040574
关键词
EndoBarrier (TM); obesity; duodenal-jejunal bypass liner; type 2 diabetes mellitus; Botnia clamp
资金
- Austrian Association for Internal Medicine
The study showed that EndoBarrier (TM) had significant effects on weight loss, reduction of fat mass, and improvement of insulin sensitivity, which remained after the removal of the device.
The EndoBarrier (TM) medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), a mean body mass index (BMI) of 43.3 +/- 5.0 (kg/m(2)) and a mean glycated haemoglobin A1c (HbA1c) of 60.6 +/- 8.6 mmol/mol were examined at baseline (before implantation of EndoBarrier (TM)), 4 weeks after implantation, at 36 weeks (right before explantation) and 24 weeks after the removal of the device to explore the short and long-term effects on glucose metabolism. Besides a significant reduction in body weight and fat mass, EndoBarrier (TM) treatment significantly improved insulin sensitivity during Botnia clamp investigations after four weeks of implantation. The beneficial effects decreased over time but remained significant 24 weeks after removal of the device.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据