Nrf2/ARE Pathway as a Therapeutic Target for the Treatment of Parkinson Diseases

NFE2L2, PPARGC1α , and pesticides and Parkinson’s disease risk and progression

(2018) Kimberly C. Paul et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway

(2018) Yang Liu et al.   Redox Biology

Oxidative stress-elicited YY1 potentiates antioxidative response via enhancement of NRF2-driven transcriptional activity: A potential neuronal defensive mechanism against ischemia/reperfusion cerebral injury

(2018) Wei Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondria in the pathophysiology of Alzheimer s and Parkinson s diseases

(2017) Isaac G Onyango   Frontiers in Bioscience-Landmark

Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes

(2017) Qian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Vitamin C and Immune Function

(2017) Anitra Carr et al.   Nutrients

PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells

(2017) Hoon-In Choi et al.   Scientific Reports

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

The NFE2L2 rs35652124 polymorphism and the risk of Parkinson’s disease

(2016) Mengru Zhu et al.   NEUROREPORT

NFE2L2 variations reduce antioxidant response in patients with Parkinson disease

(2016) YaXing Gui et al.   Oncotarget

Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis

(2016) Marie-Louise Zeissler et al.   Oncotarget

Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial

(2016) Yunes Panahi et al.   INFLAMMOPHARMACOLOGY

Cilostazol attenuates murine hepatic ischemia and reperfusion injury via heme oxygenase-dependent activation of mitochondrial biogenesis

(2015) Yeonsoo Joe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants

(2015) Amir Sarrafchi et al.   CURRENT PHARMACEUTICAL DESIGN

Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity

(2015) Yi-Hsien Tsou et al.   EXPERIMENTAL NEUROLOGY

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment

(2015) Asuka Yasueda et al.   INTEGRATIVE CANCER THERAPIES

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway

(2015) Aderbal Silva Aguiar et al.   NEUROCHEMICAL RESEARCH

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study

(2014) Malin von Otter et al.   BMC Medical Genetics

PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy

(2014) Daniel A. East et al.   CHEMISTRY & BIOLOGY

Nrf2 Signaling Contributes to the Neuroprotective Effects of Urate against 6-OHDA Toxicity

(2014) Ning Zhang et al.   PLoS One

Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target

(2013) N. K. Zenkov et al.   BIOCHEMISTRY-MOSCOW

Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

(2013) Sara Baldelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy

(2013) Samantha A Whitman et al.   EXPERIMENTAL CELL RESEARCH

Peroxisome Proliferator-activated Receptor γ Co-activator 1-α as a Critical Co-activator of the Murine Hepatic Oxidative Stress Response and Mitochondrial Biogenesis inStaphylococcus aureusSepsis

(2013) Anne D. Cherry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations

(2013) Andreas Puschmann   PARKINSONISM & RELATED DISORDERS

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice

(2012) Janhavi Athale et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

PARK2 variability in Polish Parkinson’s disease patients - interaction with mitochondrial haplogroups

(2012) Katarzyna Gaweda-Walerych et al.   PARKINSONISM & RELATED DISORDERS

Genetic analysis of NFE2L2 promoter variation in Taiwanese Parkinson's disease

(2012) Yi-Chun Chen et al.   PARKINSONISM & RELATED DISORDERS

Interaction of the Transcription Start Site Core Region and Transcription Factor YY1 Determine Ascorbate Transporter SVCT2 Exon 1a Promoter Activity

(2012) Huan Qiao et al.   PLoS One

Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator

(2010) Richard C. Scarpulla   Annals of the New York Academy of Sciences

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

(2010) Malin von Otter et al.   BMC Medical Genetics

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease

(2009) Alberto Ascherio   ARCHIVES OF NEUROLOGY

Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases

(2009) Sergio Papa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2

(2009) Fiona E. Harrison et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

(2009) Oliver Rothfuss et al.   HUMAN MOLECULAR GENETICS

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH