Article
Oncology
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Clinical Neurology
Lauren Dzikowski, Reza Mirzaei, Susobhan Sarkar, Mehul Kumar, Pinaki Bose, Anita Bellail, Chunhai Hao, V. Wee Yong
Summary: The study investigated the expression of ECM molecules in GBM patients, the effects of different ECM molecules on BTICs in culture, and the association between ECM molecules and MMP-2 and -9 in resected GBM specimens.
Review
Oncology
Igor Bryukhovetskiy
Summary: This review focuses on finding systemic solutions for immunosuppression-related issues in the treatment of glioblastoma multiforme (GBM). The study examines the ineffective immunotherapy protocols and explores the potential of creating optimal conditions to eliminate cancer stem cells (CSCs). The analysis of the interaction between hematopoietic stem cells (HSCs) and cancer cells, as well as the use of immune checkpoints and targeted medication, provides valuable insights into improving patient outcomes.
Article
Ophthalmology
Kim Santerre, Sergio Cortez Ghio, Stephanie Proulx
Summary: The study found that TGF-beta 2 can promote cell-cell and cell-substrate adhesion in corneal endothelial cells, enhance barrier integrity establishment, and improve CEC functionality.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Oncology
Rui Sun, Albert H. Kim
Summary: With the application of high throughput sequencing technologies at single-cell resolution, researchers have discovered immense cellular and tissue heterogeneity in the tumor microenvironment of glioblastoma. The interactions between malignant and immune cells generate an immunosuppressive microenvironment, while glioma stem cells play a critical role in tumor growth and therapeutic resistance.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Matilde Cescon, Elena Rampazzo, Silvia Bresolin, Francesco Da Ros, Lorenzo Manfreda, Alice Cani, Alessandro Della Puppa, Paola Braghetta, Paolo Bonaldo, Luca Persano
Summary: Collagen VI has a distinct distribution within GBM tumors and is strongly correlated with aggressive and phenotypically immature cells. It sustains the stem-like properties of GBM cells and promotes cancer cell proliferation and survival. Collagen VI plays a pivotal role in GBM tumor biology, affecting phenotypic identity, gene transcription, and response to treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mingchen Xu, Chenghe Zhao, Haiming Song, Chunmei Wang, He Li, Xudong Qiu, He Jing, Wenyue Zhuang
Summary: The ingredient Sch C in schisandra has been found to have significant therapeutic effects on pulmonary fibrosis by reducing extracellular matrix accumulation and inhibiting the production of lysyl oxidase. This study provides valuable insights into the pathogenesis of pulmonary fibrosis and potential therapeutic approaches.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Xiaoqing Fan, Junqi Fan, Haoran Yang, Chenggang Zhao, Wanxiang Niu, Zhiyou Fang, Xueran Chen
Summary: This study identified a mutation in isocitrate dehydrogenase 1 that suppresses the TGF-beta signaling pathway, while highlighting the roles of Smad3 and EP300 in promoting expression of mesenchymal markers in the mesenchymal subtype of GBM. Smad3 and hypoxia-inducible factor 1-alpha may be crucial molecular targets for treating glioma due to their coordination in cancer stem cell biology.
Article
Cardiac & Cardiovascular Systems
Andreas Edsfeldt, Pratibha Singh, Frank Matthes, Christoffer Tengryd, Michele Cavalera, Eva Bengtsson, Pontus Duner, Petr Volkov, Glykeria Karadimou, Anton Gistera, Marju Orho-Melander, Jan Nilsson, Jiangming Sun, Isabel Goncalves
Summary: This study investigated the association of TGF-beta 1, 2, and 3 isoforms with plaque stability in atherosclerosis. The results showed that TGF-beta 2 is the most abundant isoform in human plaques and may maintain plaque stability by reducing inflammation and matrix degradation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cell & Tissue Engineering
Drew W. Koch, Lauren Schnabel, Ilene M. Ellis, Rowan E. Bates, Alix K. Berglund
Summary: Treating equine bone marrow-derived MSCs with TGF-beta 2 significantly increases the production of paracrine factors and extracellular matrix molecules, which are important for tendon healing, and promotes the migration of equine tenocytes in vitro.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Summary: Glioblastoma (GBM) shares common signaling pathways involving TIM-3, an immune checkpoint, between tumor and non-tumor cells. The study reveals that TIM-3 in glioma cells not only regulates the malignant behaviors of glioma cells but also induces macrophage migration and transition to an anti-inflammatory/protumorigenic phenotype through the TIM-3/IL6 signal. Blocking this feedback loop may provide a novel therapeutic strategy for GBM.
Article
Chemistry, Physical
Whee-Soo Kim, Sungjin Min, Su Kyeom Kim, Sunghwi Kang, Soohwan An, Ernesto Criado-Hidalgo, Hunter Davis, Avinoam Bar-Zion, Dina Malounda, Yu Heun Kim, Jae-Hyun Lee, Soo Han Bae, Jin Gu Lee, Minsuk Kwak, Seung-Woo Cho, Mikhail G. Shapiro, Jinwoo Cheon
Summary: Magneto-gas vesicles (MGVs) are protein nanostructures that combine gas vesicles and magnetic nanoparticles, enabling non-invasive, long-term, and quantitative monitoring of mechanical properties in living tissues. They significantly improve signal strength and detection sensitivity, offering potential for non-invasive imaging of tissue elasticity and applications in disease diagnosis and treatment.
Article
Cell & Tissue Engineering
JongMyung Kim, Marine Potez, Chunhua She, Ping Huang, Qiulian Wu, Shideng Bao, Jeremy N. Rich, James K. C. Liu
Summary: Researchers have successfully isolated a 7-amino acid peptide, AWEFYFP, using in vitro and in vivo phage display biopanning methods. This peptide targets glioblastoma stem cells specifically and has the ability to penetrate the blood-brain barrier. It was found that Cadherin 2 is the receptor targeted by the peptide on glioblastoma cells.
Article
Oncology
Hannah Clancy, Michal Pruski, Bing Lang, Jared Ching, Colin D. McCaig
Summary: This study demonstrates opposing preferences for electric field responses in primary GBM differentiated cells and GSCs, which can be chemically inhibited by pioglitazone. Western blot analysis did not show any changes in PPARγ expression with or without exposure to the electric field.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Xun Ye, Jinhu Li, Zibo Liu, Xue Sun, Daneng Wei, Linjiang Song, Chunjie Wu
Summary: Fibrosis is a disease characterized by excessive accumulation of extracellular matrix, which can lead to organ failure and death. Activated myofibroblasts have been identified as the main cellular elements responsible for the replacement of normal tissues with nonfunctional fibrotic tissue. The transforming growth factor-beta pathway plays a significant role in fibrosis. Although there is no specific drug for fibrosis treatment, various peptides have shown promise in anti-fibrosis therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
