期刊
MACROMOLECULAR BIOSCIENCE
卷 19, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201800281
关键词
drug delivery; injectable biomaterials; materials chemistry; rheology
资金
- University of Notre Dame Advancing our Vision initiative
- American Cancer Society [IRG-14-195-01]
- Helmsley Charitable Trust
- Notre Dame Advanced Diagnostics and Therapeutics
- Notre Dame Center for Nanoscience and Technology
Hydrogel biomaterials are pervasive in biomedical use. Applications of these soft materials range from contact lenses to drug depots to scaffolds for transplanted cells. A subset of hydrogels is prepared from physical cross-linking mediated by host-guest interactions. Host macrocycles, the most recognizable supramolecular motif, facilitate complex formation with an array of guests by inclusion in their portal. Commonly, an appended macrocycle forms a complex with appended guests on another polymer chain. The formation of poly(pseudo)rotaxanes is also demonstrated, wherein macrocycles are threaded by a polymer chain to give rise to physical cross-linking by secondary non-covalent interactions or polymer jamming. Host-guest supramolecular hydrogels lend themselves to a variety of applications resulting from their dynamic properties that arise from non-covalent supramolecular interactions, as well as engineered responsiveness to external stimuli. These are thus an exciting new class of materials.
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