期刊
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
卷 13, 期 1, 页码 99-109出版社
WILEY
DOI: 10.1002/term.2772
关键词
CX3CR1; macrophages; RhoAactin; ROCK kinase; wound healing
类别
资金
- William Stamps Farish Fund
- Polish Ministry of National Defense project Kosciuszko [5508/2017/DA, 571/2016/DA]
Macrophages play a crucial role in regeneration and consecutive phases of wound healing. In this review, we summarise current knowledge on the ontogeny, origin, phenotypical heterogeneity, and functional exchangeability of macrophages participating in these processes. We also describe the genetic, pharmacologic, and bioengineering methods for manipulation of macrophage phenotype and functions and their potential for development of the novel, clinically applicable therapies.
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