Insights into the Basal Activity and Activation Mechanism of the β1 Adrenergic Receptor Using Native Mass Spectrometry

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

(2018) Hsin-Yung Yen et al.   NATURE

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Ligand binding to a G protein–coupled receptor captured in a mass spectrometer

(2017) Hsin-Yung Yen et al.   Science Advances

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

(2016) Brian T. DeVree et al.   NATURE

Mass spectrometry of intact membrane protein complexes

(2013) Arthur Laganowsky et al.   Nature Protocols

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

(2013) J. Marcoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphipathic Polymers Enable the Study of Functional Membrane Proteins in the Gas Phase

(2012) Aneika C. Leney et al.   ANALYTICAL CHEMISTRY

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Charge state and adduct reduction in electrospray ionization–mass spectrometry using solvent vapor exposure

(2011) Jonathan T.S. Hopper et al.   ANALYTICAL BIOCHEMISTRY

Engineering an Ultra-Thermostable β1-Adrenoceptor

(2011) Jennifer L. Miller et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions

(2009) Nelson P Barrera et al.   NATURE METHODS

The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

(2008) Denis J. Dupré et al.   Annual Review of Pharmacology and Toxicology

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Micelles Protect Membrane Complexes from Solution to Vacuum

(2008) N. P. Barrera et al.   SCIENCE