Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets

Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation

(2018) Matthew T. Dickerson et al.   Scientific Reports

Interplay between tight junctions & adherens junctions

(2017) Hannah K. Campbell et al.   EXPERIMENTAL CELL RESEARCH

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ

(2015) Nikki L. Farnsworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-color fluorescent analysis of connexin 36 turnover: relationship to functional plasticity

(2015) H. Y. Wang et al.   JOURNAL OF CELL SCIENCE

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

(2015) Makoto Shigeto et al.   JOURNAL OF CLINICAL INVESTIGATION

Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology

(2015) David Grundy   JOURNAL OF PHYSIOLOGY-LONDON

Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina

(2015) Elena Ivanova et al.   Frontiers in Cellular Neuroscience

Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability

(2015) X Tong et al.   Cell Death & Disease

Dimensionality and Size Scaling of Coordinated Ca2+ Dynamics in MIN6 β-cell Clusters

(2014) Thomas H. Hraha et al.   BIOPHYSICAL JOURNAL

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+in Female Mouse Islets Stimulated by Glucose and Tolbutamide

(2014) Jean-Claude Henquin et al.   ENDOCRINOLOGY

New insights into the role of connexins in pancreatic islet function and diabetes

(2014) Nikki L. Farnsworth et al.   FEBS LETTERS

Fluorescence recovery after photobleaching reveals regulation and distribution of connexin36 gap junction coupling within mouse islets of Langerhans

(2014) Nikki L. Farnsworth et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity

(2013) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Lipotoxicity disrupts incretin-regulated human β cell connectivity

(2013) David J. Hodson et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ

(2013) Jacques-Antoine Haefliger et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Islet inflammation: a unifying target for diabetes treatment?

(2013) Yumi Imai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Biphasic increase of gap junction coupling induced by dipyridamole in the rat aortic A-10 vascular smooth muscle cell line

(2013) Daniela Begandt et al.   Journal of Cell Communication and Signaling

Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice

(2012) C. P. F. Carvalho et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The In Vivo  -to- -Cell Chat Room: Connexin Connections Matter

(2012) P. Meda   DIABETES

Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

(2012) W. S. Head et al.   DIABETES

The central role of calcium in the effects of cytokines on beta-cell function: Implications for type 1 and type 2 diabetes

(2011) James W. Ramadan et al.   CELL CALCIUM

Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC- 

(2011) C. Cabou et al.   DIABETES

The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain

(2011) X. Li et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Connexins protect mouse pancreatic β cells against apoptosis

(2011) Philippe Klee et al.   JOURNAL OF CLINICAL INVESTIGATION

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts

(2011) Lei Tian et al.   TRANSPLANT INTERNATIONAL

PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans

(2009) Oleg G. Chepurny et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in  -Cells

(2009) L. G. Grunnet et al.   DIABETES

Dopamine-Stimulated Dephosphorylation of Connexin 36 Mediates AII Amacrine Cell Uncoupling

(2009) W. W. Kothmann et al.   JOURNAL OF NEUROSCIENCE

The role of membrane microdomains in shaping β2-adrenergic receptor-mediated cAMP dynamics

(2009) Lisa M. DiPilato et al.   Molecular BioSystems

β-Cell deterioration during diabetes: what's in the gun?

(2009) R. Paul Robertson   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gap Junction Coupling and Calcium Waves in the Pancreatic Islet

(2008) Richard K.P. Benninger et al.   BIOPHYSICAL JOURNAL

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

(2008) Véronique Serre-Beinier et al.   HUMAN MOLECULAR GENETICS

Exendin-4 Modulates Diabetes Onset in Nonobese Diabetic Mice

(2007) Irene Hadjiyanni et al.   ENDOCRINOLOGY