Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease
出版年份 2018 全文链接
标题
Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease
作者
关键词
-
出版物
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 96, Issue 12, Pages 1359-1373
出版商
Springer Nature America, Inc
发表日期
2018-10-20
DOI
10.1007/s00109-018-1703-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Progranulin: A key player in autoimmune diseases
- (2018) Jinlong Jian et al. CYTOKINE
- Foxo4- and Stat3-dependent IL-10 production by progranulin in regulatory T cells restrains inflammatory arthritis
- (2017) Wenyu Fu et al. FASEB JOURNAL
- Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
- (2017) Sander Beel et al. HUMAN MOLECULAR GENETICS
- In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay–Sachs disease
- (2017) Atsushi Kato et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency
- (2017) Bret M. Evers et al. Cell Reports
- The role of progranulin in arthritis
- (2016) Jianlu Wei et al. Annals of the New York Academy of Sciences
- Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism
- (2016) Konrad Sandhoff BIOCHIMIE
- Serum progranulin levels in Hispanic rheumatoid arthritis patients treated with TNF antagonists: a prospective, observational study
- (2016) Jennifer Johnson et al. CLINICAL RHEUMATOLOGY
- Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock
- (2016) Yuan Yu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Tay–Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum–associated degradation
- (2016) Devin Dersh et al. MOLECULAR BIOLOGY OF THE CELL
- Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling
- (2016) Anwen Williams et al. Arthritis & Rheumatology
- Progranulin as a Novel Factor in Gaucher Disease
- (2016) Francis Y.M. Choy et al. EBioMedicine
- Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
- (2016) Jinlong Jian et al. EBioMedicine
- Association Between Progranulin and Gaucher Disease
- (2016) Jinlong Jian et al. EBioMedicine
- Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner
- (2016) Jyoti Joshi Mundra et al. Scientific Reports
- Progranulin protects against the tissue damage of acute ischaemic stroke: Figure 1
- (2015) Chunyu Zhao et al. BRAIN
- Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity
- (2015) Susi Anheuser et al. JOURNAL OF LIPID RESEARCH
- Effect of cyclic, low dose pyrimethamine treatment in patients with Late Onset Tay Sachs: an open label, extended pilot study
- (2015) Etty Osher et al. Orphanet Journal of Rare Diseases
- New discovery rarely runs smooth: an update on progranulin/TNFR interactions
- (2015) Betty C. Wang et al. Protein & Cell
- Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling
- (2014) Yun-peng Zhao et al. ANNALS OF THE RHEUMATIC DISEASES
- Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2
- (2014) Meiling Li et al. CELLULAR SIGNALLING
- Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity
- (2014) Qingyun Tian Frontiers in Bioscience-Landmark
- Progranulin Facilitates Conversion and Function of Regulatory T Cells under Inflammatory Conditions
- (2014) Fanhua Wei et al. PLoS One
- PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
- (2014) Fanhua Wei et al. Scientific Reports
- Interleukin 13– and Interleukin 17A–Induced Pulmonary Hypertension Phenotype Due to Inhalation of Antigen and Fine Particles from Air Pollution
- (2014) Sung-Hyun Park et al. Pulmonary Circulation
- Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
- (2014) Yoshinori Tanaka et al. Acta Neuropathologica Communications
- The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling
- (2013) Yun-peng Zhao et al. BIOMATERIALS
- Progranulin deficiency exaggerates, whereas progranulin-derived Atsttrin attenuates, severity of dermatitis in mice
- (2013) Yun-Peng Zhao et al. FEBS LETTERS
- Insights into the role of progranulin in immunity, infection, and inflammation
- (2012) J. Jian et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Progranulin regulates neuronal outgrowth independent of Sortilin
- (2012) Jennifer Gass et al. Molecular Neurodegeneration
- Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
- (2012) Qing-Yun Tian et al. Jove-Journal of Visualized Experiments
- Therapeutic Potential of Intracerebroventricular Replacement of Modified Human β-Hexosaminidase B for GM2 Gangliosidosis
- (2011) Kazuhiko Matsuoka et al. MOLECULAR THERAPY
- Progranulin: A growth factor, a novel TNFR ligand and a drug target
- (2011) Chuan-ju Liu et al. PHARMACOLOGY & THERAPEUTICS
- The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
- (2011) W. Tang et al. SCIENCE
- Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging
- (2010) Zeshan Ahmed et al. AMERICAN JOURNAL OF PATHOLOGY
- Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis
- (2010) Jian Q. Feng et al. FASEB JOURNAL
- An open-label Phase I/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 gangliosidosis (Tay–Sachs or Sandhoff variants)
- (2010) Joe T.R. Clarke et al. MOLECULAR GENETICS AND METABOLISM
- Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology
- (2010) Thomas Kirkegaard et al. NATURE
- Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease
- (2009) J. S. Shane Rountree et al. ChemMedChem
- Miglustat in late-onset Tay-Sachs disease: a 12-month, randomized, controlled clinical study with 24 months of extended treatment
- (2009) Barbara E Shapiro et al. GENETICS IN MEDICINE
- Secondary lipid accumulation in lysosomal disease
- (2008) Steven U. Walkley et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Hexosaminidase assays
- (2008) Michaela Wendeler et al. GLYCOCONJUGATE JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started