Article
Multidisciplinary Sciences
Lindsay A. Welikovitch, Simon Dujardin, Amy R. Dunn, Analiese R. Fernandes, Anita Khasnavis, Lori B. Chibnik, Catherine C. Kaczorowski, Bradley T. Hyman
Summary: The speed and scope of cognitive deterioration in Alzheimer's disease is closely associated with the advancement of tau neurofibrillary lesions across brain networks. Our study tested whether the rate of tau propagation is a heritable disease trait in mice, and found that 43% of the variability in tau spread was due to genetic variants segregating across different mouse strains. The identification of unique genetic variants that influence the progression of pathological tau may lead to the development of novel molecular targets to prevent or slow down tau spread and cognitive decline.
Article
Immunology
Nathan M. Ryan, Jessica A. Hess, Fernando Pardo-Manuel de Villena, Benjamin E. Leiby, Ayako Shimada, Lei Yu, Amir Yarmahmoodi, Nikolai Petrovsky, Bin Zhan, Maria Elena Bottazzi, Benjamin L. Makepeace, Sara Lustigman, David Abraham
Summary: This study demonstrated that an Onchocerca volvulus vaccine can induce protective immunity in genetically diverse mice, with each mouse line showing a unique immune response to the vaccine and challenge. The findings suggest that the vaccine is polyfunctional and effective in genetically complex populations.
Article
Infectious Diseases
Kwai Lin Thong, Kathryn Bee Lin Tham, Soo Tein Ngoi, Shiang Chiet Tan, Wan Noraini Wan Yussof, Rahayu Ahmad Hanapi, Nurizzat Mohamad, Cindy Shuan Ju Teh
Summary: This study investigated the genetic characteristics of V. cholerae O1 El Tor strains associated with cholera outbreaks and sporadic cases in Malaysia, showing the presence of a genetically diverse population of El Tor variants in the region, suggesting a multiclonal emergence of V. cholerae O1 El Tor variants in the area.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Cell Biology
Uma P. Arora, Beth A. Sullivan, Beth L. Dumont
Summary: This study investigates the interplay between centromere variation and kinetochore protein sequence association in mice, and reveals strain-level differences in both CENP-A positioning and sequence preference along the core centromere satellite.
Article
Behavioral Sciences
Lauren S. Bailey, Jared R. Bagley, Rainy Dodd, Ashley Olson, Mikayla Bolduc, Vivek M. Philip, Laura G. Reinholdt, Stacey J. Sukoff Rizzo, Lisa Tarantino, Leona Gagnon, Elissa J. Chesler, James David Jentsch
Summary: This study examined reward sensitivity and impulsivity traits using different strains of mice, finding significant heritability for impulsive action, impulsive choice, waiting impulsivity, locomotor activity, and reward sensitivity. The research also identified these impulsive phenotypes as non-correlating, independent traits.
GENES BRAIN AND BEHAVIOR
(2021)
Article
Substance Abuse
Jared R. Bagley, Elissa J. Chesler, Vivek M. Philip, James D. Jentsch
Summary: Genetic factors play a role in voluntary ethanol consumption and pharmacokinetics, with different mouse populations showing varying levels of genetic diversity. The PWK/PhJ strain exhibits the highest ethanol consumption, and it was found that sex moderates genetic effects on voluntary ethanol drinking.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Peng Qin, Hongwei Lu, Huilong Du, Hao Wang, Weilan Chen, Zhuo Chen, Qiang He, Shujun Ou, Hongyu Zhang, Xuanzhao Li, Xiuxiu Li, Yan Li, Yi Liao, Qiang Gao, Bin Tu, Hua Yuan, Bingtian Ma, Yuping Wang, Yangwen Qian, Shijun Fan, Weitao Li, Jing Wang, Min He, Junjie Yin, Ting Li, Ning Jiang, Xuewei Chen, Chengzhi Liang, Shigui Li
Summary: The study assembled high-quality genomes of genetically diverse rice accessions, discovering a large number of structural variations and gene copy number variations. By using a graph-based genome, the research explored the impact of these variations on rice domestication and environmental adaptation.
Article
Dentistry, Oral Surgery & Medicine
Suzana Zivanovic, Milos Papic, Tamara Vucicevic, Marina Miletic Kovacevic, Nemanja Jovicic, Nadja Nikolic, Jelena Milasin, Verica Paunovic, Vladimir Trajkovic, Slobodanka Mitrovic, Miodrag L. Lukic, Aleksandra Lukic, Biljana Ljujic
Summary: After pulp exposure, DA rats developed significantly larger periapical lesions compared to AO rats, with genetically determined differences in immunopathology playing a significant role in defining the severity of periapical lesions.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Review
Immunology
Roos M. de Jong, Lisette Meerstein-Kessel, Dari F. Da, Sandrine Nsango, Joseph D. Challenger, Marga van de Vegte-bolmer, Geert-Jan van Gemert, Elias Duarte, Noam Teyssier, Robert W. Sauerwein, Thomas S. Churcher, Roch K. Dabire, Isabelle Morlais, Emily Locke, Martijn A. Huynen, Teun Bousema, Matthijs M. Jore
Summary: This study investigated the impact of natural genetic diversity on the functional activity of transmission-blocking antibodies. Despite the conserved nature of sexual stage antigens, minor sequence variation can significantly impact the efficacy of transmission-blocking antibodies. The findings support further clinical development of mAb 45.1 and may inform Pfs48/45 vaccine design.
Article
Biochemistry & Molecular Biology
Laura E. Griffin, Lauren Essenmacher, Kathryn C. Racine, Lisard Iglesias-Carres, Jeffery S. Tessem, Susan M. Smith, Andrew P. Neilson
Summary: The protective effects of flavonoids against obesity in animal models do not always translate to humans, possibly due to the use of a limited number of mouse strains in obesity studies. The complex interactions among genetic factors, sex, obesity stimuli, and flavonoid intake highlight the need to move away from single inbred mouse models. Diverse responses to diet-induced obesity were observed across different mouse strains and sexes, emphasizing the importance of using genetically diverse models for personalized nutrition research.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Immunology
Qiuyue Ma, Melissa Grigorescu, Adrian Schreiber, Ralph Kettritz, Maja Lindenmeyer, Hans-Joachim Anders, Stefanie Steiger
Summary: Genetic background plays a significant role in determining the formation of kidney stones in mice, while the intestinal microbiome has minimal impact on this phenomenon.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Johanna Schaffenrath, Sheng-Fu Huang, Tania Wyss, Mauro Delorenzi, Annika Keller
Summary: Genetic variation in a population influences the manifestation of diseases, common lab mouse strains lack genetic variability in humans, brain vasculature functionality is crucial for brain diseases, BBB acts as a major obstacle for drug delivery into CNS.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Food Science & Technology
Andreas Roetzer, Nina Model, Jakob Laube, Yvonne Unterhumer, Guenter Haller, Martha M. Eibl
Summary: Staphylococcus aureus is a common pathogen that can cause severe infections, with its exotoxins playing an important role in the pathogenesis of the disease. Genomic analysis and functional analysis can help identify disease-causing exotoxins and study their superantigenic properties.
Article
Immunology
Jessica R. Spengler, Markus H. Kainulainen, Stephen R. Welch, Jo Ann D. Coleman-McCray, Jessica R. Harmon, Jillian A. Condrey, Florine E. M. Scholte, Stuart T. Nichol, Joel M. Montgomery, Cesar G. Albarino, Christina F. Spiropoulou
Summary: This study provides a detailed clinical course of guinea pigs infected with different strains of Lassa virus and develops models for disease research. The efficacy of a virus replicon particle vaccine against heterologous Lassa virus challenge is evaluated, showing complete protection after a single vaccination dose.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Chang-Gi Jeong, Amina Khatun, Salik Nazki, Seung-Chai Kim, Yun-Hee Noh, Sang-Chul Kang, Dong-Uk Lee, Myeon-Sik Yang, Nadeem Shabir, In-Joong Yoon, Bumseok Kim, Won-Il Kim
Summary: The chimeric PRRS vaccine JB1 is safe and effective, providing simultaneous protection against two genetically different PRRSV strains, with pregnant sows and piglets both showing significant improvements in viremia levels, antibody production, abortion rates, piglet viability, and viral concentrations.
Article
Medicine, General & Internal
Delphine Planas, Amelie Pagliuzza, Rosalie Ponte, Augustine Fert, Laurence Raymond Marchand, Marta Massanella, Annie Gosselin, Vikram Mehraj, Franck P. Dupuy, Stephane Isnard, Jean-Philippe Goulet, Sylvie Lesage, Eric A. Cohen, Mager Peter Ghali, Jonathan B. Angel, Nicolas Chomont, Jean-Pierre Routy, Petronela Ancuta
Summary: Metformin showed minor effects on immunological/virological markers and mTOR activation/phosphorylation in the blood, but significantly decreased CD4(+) T-cell infiltration and mTOR activation/phosphorylation in the colon, especially in CCR6(+)CD4(+) T-cells.
Article
Genetics & Heredity
Roxanne Collin, Veronique Dugas, Adam-Nicolas Pelletier, Genevieve Chabot-Roy, Sylvie Lesage
Summary: Susceptibility to autoimmune diabetes is a complex genetic trait, and linkage analyses using NOD mice have identified genetic interactions in defining the proportion of DN T cells. Furthermore, evidence of genetic epistasis within a locus on chromosome 12 influencing autoimmune susceptibility has been revealed.
Article
Gastroenterology & Hepatology
Gabrielle Boucher, Alexandre Paradis, Genevieve Chabot-Roy, Lise Coderre, Erin E. Hillhouse, Alain Bitton, Christine Des Rosiers, Megan K. Levings, L. Philip Schumm, Mark Lazarev, Steve R. Brant, Richard Duerr, Dermot McGovern, Mark S. Silverberg, Judy Cho, Sylvie Lesage, John D. Rioux
Summary: This study identified elevated levels of multiple serum analytes in Crohn's disease (CD) patients, implicating multiple cell types from the immune, epithelial, and endothelial systems. These circulating analytes reflect the ongoing inflammatory processes within the gut. Furthermore, distinct profiles according to disease location support the biological difference between ileal and colonic CD, consistent with previous genetic and clinical observations.
INFLAMMATORY BOWEL DISEASES
(2022)
Editorial Material
Clinical Neurology
Sylvie Lesage, Adrian Liston
Editorial Material
Clinical Neurology
Adrian Liston, Sylvie Lesage
Review
Endocrinology & Metabolism
Lise Coderre, Lyna Debieche, Joelle Plourde, Remi Rabasa-Lhoret, Sylvie Lesage
Summary: Cystic fibrosis-related diabetes (CFRD) is a common comorbidity in cystic fibrosis patients, with a prevalence of over 50% in adults. The etiology of CFRD is not fully understood, but research suggests it may result from beta-cell extrinsic factors. Inflammation and ductal cells near beta-cells could play a role in CFRD development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Fiona C. Simpson, Christopher D. McTiernan, Mohammad Mirazul Islam, Oleksiy Buznyk, Philip N. Lewis, Keith M. Meek, Michel Haagdorens, Cindy Audiger, Sylvie Lesage, Francois-Xavier Gueriot, Isabelle Brunette, Marie-Claude Robert, David Olsen, Laura Koivusalo, Aneta Liszka, Per Fagerholm, Miguel Gonzalez-Andrades, May Griffith
Summary: By developing fully synthetic corneal implants, Simpson, McTiernan et al. demonstrate that CLP-PEG-MPC implants show reduced inflammation-induced corneal rejection, promote faster nerve regeneration and recovery of corneal sensation compared to CLP-PEG only implants. The study suggests the superiority of CLP-PEG-MPC implants in promoting corneal regeneration.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Felix Lombard-Vadnais, Roxanne Collin, Jean-Francois Daudelin, Genevieve Chabot-Roy, Nathalie Labrecque, Sylvie Lesage
Summary: The study reveals that resistance alleles at the Idd2 locus impair the formation of spontaneous and induced germinal centers and influence the expression of specific MHC molecules, both of which contribute to the reduced incidence of type 1 diabetes.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Felix Lombard-Vadnais, Julie Lacombe, Genevieve Chabot-Roy, Mathieu Ferron, Sylvie Lesage
Summary: Pou2af1 is a key coactivator in B-cell maturation, but its role in T cells is unclear. In this study, genetic disruption of Pou2af1 in T cells did not impair their cytokine production, suggesting that it does not act as a direct transcriptional coactivator in T cells. However, deletion of Pou2af1 in B cells indirectly affected Tfh differentiation, clarifying the role of OCA-B in the immune system.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Review
Immunology
Anne-Marie Aubin, Felix Lombard-Vadnais, Roxanne Collin, Holly A. Aliesky, Sandra M. McLachlan, Sylvie Lesage
Summary: NOD mice are an important model for studying autoimmune diseases, with characteristics of multiple autoimmune diseases in addition to diabetes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco Jose Naranjo-Galindo, Felix Lombard-Vadnais, Steffie Junius, David Bending, Masahiro Ono, Tino Hochepied, Timotheus Y. F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Summary: The study reveals the contextual influence of IL-2 function and its effects on different cell circuits. Targeted IL-2 production has the potential to fine-tune therapeutic responses, based on the desired clinical outcomes.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sarai Mola, Claudine Beauchamp, Gabrielle Boucher, Sylvie Lesage, Mohamad Karaky, Philippe Goyette, Sylvain Foisy, John D. Rioux
Summary: This study identified multiple transcript variants of immune-related genes, which are differentially expressed and likely to affect cell functions in different immune cells. The research utilized RNA sequencing and a heuristic approach to successfully identify these multi-transcript genes. The findings are important for understanding the transcriptional regulation of immune cells.
MOLECULAR IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Felix Lombard-Vadnais, Genevieve Chabot-Roy, Astrid Zahn, Sahily Rodriguez Torres, Javier M. Di Noia, Heather J. Melichar, Sylvie Lesage
Summary: The elimination of self-reactive T cells in the thymus is crucial for establishing T-cell tolerance. Thymic B cells have been found to play a role in this process. This study focused on investigating the phenotype of thymic B cells in different mouse strains, particularly the non-obese diabetic (NOD) mice which serve as a model for autoimmune diabetes. The study found that reduced isotype switching of NOD thymic B cells contributed to a decrease in thymocyte selection and an increase in self-reactive CD4(+) T cells, suggesting the importance of AID expression in thymic B cells for T-cell tolerance.
Review
Food Science & Technology
Caroline R. Hill, Alex Haoci Liu, Lyn Mccahon, Liezhou Zhong, Armaghan Shafaei, Lois Balmer, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst
Summary: Higher intakes of cruciferous and allium vegetables are associated with a lower risk of cardiometabolic-related outcomes. This scoping review explores the potential roles of S-methyl cysteine sulfoxide (SMCSO) found in these vegetables and its mechanisms of action. Animal studies suggest that SMCSO has anti-hyperglycemic, anti-hypercholesterolemic, antioxidant, anticancer, and antibacterial properties. More research, especially human studies, is needed to further understand the health benefits of SMCSO, particularly for cardiometabolic and inflammatory-based pathologies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cell Biology
Capucine Bourel, Victor Mullins-Dansereau, Maher Al Khaldi, Genevieve Chabot-Roy, Felix Lombard-Vadnais, Sylvie Lesage
Summary: NK cells are innate immune cells that target infected and tumor cells. mNK cells from NOD mice exhibit a defect in functional maturation and have impaired cytotoxic functions, which is independent of their functional maturation defect. The study shows that the expression of granzyme B is severely impaired in mNK cells from NOD mice, explaining their inability to control tumor growth in vivo. Therefore, phenotypic functional maturation of mNK cells can be uncoupled from the acquisition of cytotoxic functions.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
