Article
Immunology
Bruno Jennings-Almeida, Juliana P. Castelpoggi, Erivan S. Ramos-Junior, Eliane de Oliveira Ferreira, Regina M. C. P. Domingues, Juliana Echevarria-Lima, Robson Coutinho-Silva, Aline C. A. Moreira-Souza, Eliana Marino, Charles R. Mackay, Dario S. Zamboni, Maria Bellio, Julio Scharfstein, Leandro A. Lobo, Ana Carolina Oliveira
Summary: The intestinal barrier is crucial for gut homeostasis, and a breach can lead to severe inflammatory responses, where IL-1 beta plays a significant role in peritonitis and sepsis.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiaqi Lin, Jinxuan Ren, Bin Zhu, Yi Dai, Dave Schwinn Gao, Suyun Xia, Zhenzhen Cheng, Yangyuxin Huang, Lina Yu
Summary: This study reveals the analgesic effects of Dimethyl Itaconate (DI), a derivative of itaconate, on inflammatory pain. DI can reduce mechanical allodynia and thermal hyperalgesia, inhibit neuroinflammation in peripheral and central sites, and regulate the expression of inflammatory mediators and NLRP3 inflammasome complex.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yufei Luo, Bojun Xiong, Haiping Liu, Zehong Chen, Huihui Huang, Changxi Yu, Jian Yang
Summary: Koumine inhibits NLRP3 inflammasome activation and reduces neutrophil infiltration and IL-1β production, both in vitro and in vivo. The inhibitory effect involves blocking the ROS/NF-kappa B/NLRP3 signal axis, suggesting potential clinical applications for NLRP3 inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Prapakorn Wisitpongpun, Pachuen Potup, Kanchana Usuwanthim
Summary: This study investigated the effects of oleamide on macrophage polarization and NLRP3 inflammasome activation. The results showed that oleamide promoted M1 macrophage polarization and increased IL-1 beta production. Additionally, oleamide appeared to activate the NLRP3 inflammasome as a second signal. These findings reveal a new function for oleamide and potential targets for treating NLRP3-related inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Taiki Mori, Hideo Kataoka, Gen Tanabe, Takeshi Into
Summary: The bioactivity of the synthetic peptide candidalysin is affected by its solubility depending on the solvent employed. Candidalysin dissolved in water has lower activity compared to candidalysin dissolved in dimethyl sulfoxide. In addition, the NLRP3-dependent activity is caused by insoluble microparticles.
Article
Immunology
Chaoqing Zhong, Ruiqing Wang, Mingqiang Hua, Chen Zhang, Fengjiao Han, Miao Xu, Xinyu Yang, Guosheng Li, Xiang Hu, Tao Sun, Chunyan Ji, Daoxin Ma
Summary: NLRP3 inflammasome is over-expressed and highly activated in AML bone marrow leukemia cells, promoting leukemia cell proliferation, inhibiting apoptosis and increasing resistance to chemotherapy. IL-1 beta plays a crucial role in this process. Targeting NLRP3 inflammasome may offer a novel therapeutic option for AML.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kai Chen, Qiuping Hu, Zhongcong Xie, Guang Yang
Summary: This study reveals that surgery leads to neuronal hypoactivity and impairs learning-dependent dendritic spine formation, resulting in deficits in multiple learning tasks. These neuronal and synaptic alterations are mediated by peripheral monocytes through NLRP3 inflammasome-dependent IL-1β production. Decreasing peripheral monocytes or inactivating NLRP3 inflammasomes can reduce IL-1β levels and improve neuronal and behavioral deficits.
Article
Immunology
Zi-Teng Zhang, Xiao-Lei Gu, Xin Zhao, Xian He, Hao-Wei Shi, Kun Zhang, Yi-Ming Zhang, Yi-Nan Su, Jiang-Bo Zhu, Zhi-Wei Li, Guo-Bao Li
Summary: Prior infection simulated by LPS/LTA injection resulted in latent inflammation with high cytokine levels, but did not affect animal survival or body temperature. Heat treatment induced heat stroke and death in animals without prior infection, showing no significant systemic or neuroinflammation. NLRP3 inflammasome-induced neuroinflammation was detected in animals with prior infection, and Nlrp3 knockout mice showed enhanced heat tolerance and reduced hypothalamus IL-1 beta production. IL-1 beta neutralizing antibody injection extended endotoxemic mice survival under heat stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Veterinary Sciences
Pei Gao, Shiyuan Zhang, Xinxin Zhang, Chenggang Xu, Libin Chen, Lei Fan, Jinlian Ren, Qiuyan Lin, Bin Xiang, Tao Ren
Summary: This study investigates the expression and tissue distribution of S1PR1 after NDV infection and demonstrates that S1PR1 regulates IL-1 beta expression mainly through the NLRP3/caspase-1 inflammasome. The findings reveal the molecular mechanism underlying the inflammatory response induced by NDV infection.
VETERINARY RESEARCH
(2022)
Article
Immunology
Hana Starobova, Mercedes Monteleone, Christelle Adolphe, Lena Batoon, Cheyenne J. Sandrock, Bryan Tay, Jennifer R. Deuis, Alexandra V. Smith, Alexander Mueller, Evelyn Israel Nadar, Grace Pamo Lawrence, Amanda Mayor, Elissa Tolson, Jean-Pierre Levesque, Allison R. Pettit, Brandon J. Wainwright, Kate Schroder, Irina Vetter
Summary: The study found that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and release of interleukin-1 beta. Treatment with NLRP3 inhibitor or IL-1 receptor antagonist could effectively reduce mechanical allodynia and gait disturbances. Repurposing anakinra may be an effective co-treatment strategy to prevent vincristine-induced peripheral neuropathy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Fengqing Hou, Lianci Peng, Jiali Jiang, Tingting Chen, Dongyi Xu, Qingyuan Huang, Chao Ye, Yuanyi Peng, Dong-Liang Hu, Rendong Fang
Summary: Staphylococcus aureus is an important zoonotic food-borne pathogen that can cause severe infections. A study found that the enterotoxin O of S. aureus can induce interleukin-1 beta secretion in mouse neutrophils, which is dependent on the activation of TLR4/JNK/NLRP3 inflammasome signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Cara Lang, Sohini Roy, Yu Wang, Diana Graves, Yaomin Xu, C. Henrique Serezani, Michael Korrer, Young J. Kim
Summary: The expression of inflammasome-associated genes, NLRP3 and IL-1β, is enriched in specific monocyte and macrophage subtypes in tumor-infiltrating myeloid cells in Head and Neck Squamous Cell Carcinoma (HNSCC). Deletion of NLRP3 gene promotes tumor progression, while caspase-1 signaling in myeloid cells increases myeloid survival and drives tumor growth through phagocyte-mediated inflammasome signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Quan-Bo Zhang, Dan Zhu, Fei Dai, Yu-Qin Huang, Jian-Xiong Zheng, Yi-Ping Tang, Zeng-Rong Dong, Xia Liao, Yu-Feng Qing
Summary: MiR-223 serves as a negative regulator in the development of gouty inflammation by suppressing the production of IL-1 beta and TNF-alpha, rather than by regulating IL-37 and TGF-beta 1. Additionally, miR-223 regulates cytokine production by targeting the NLRP3 inflammasome.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Judith Bockstiegel, Silas L. Wurnig, Jonas Engelhardt, Jana Enns, Finn K. Hansen, Guenther Weindl
Summary: The deficiency of HDAC6 does not affect the release of IL-1β mediated by NLRP3 in human immune cells, indicating that the inhibition of HDAC6 is not necessary for the function of the NLRP3 pathway. In addition, HDAC6 inhibitors have the potential to suppress inflammatory responses and inhibit the release of IL-1β by regulating Toll-like receptor (TLR) signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Neurosciences
Jingrui Pan, Jialing Peng, Xiangpen Li, Hongxuan Wang, Xiaoming Rong, Ying Peng
Summary: This study reveals that microglia activate NLRP3 inflammasomes in neurons and endothelial cells via IL-1 beta/IL-1R1/TRAF6 signaling pathway, promoting cerebral ischemia and reperfusion injury. Inhibition of IL-1R1 can block inflammatory damage and prevent excessive infiltration of leukocytes into the brain, leading to better neurological outcome.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mick Frissen, Lijun Liao, Kai Markus Schneider, Sonja Djudjaj, Johannes Haybaeck, Alexander Wree, Ulrike Rolle-Kampczyk, Martin von Bergen, Eicke Latz, Peter Boor, Christian Trautwein
Summary: NLRP3 plays a different role in acute and chronic cholestatic liver injury compared to kidney injury. Disease progression during chronic cholestasis can be targeted through small molecules, suggesting potential clinical benefits for humans in attenuating liver and kidney injury.
Article
Cell Biology
Mario A. Lauterbach, Victor Saavedra, Matthew S. J. Mangan, Anke Penno, Christoph Thiele, Eicke Latz, Lars Kuerschner
Summary: The study reveals that deoxysphingolipids have an impact on autophagy, potentially leading to inflammation and abnormalities in the innate immune system.
Article
Biochemistry & Molecular Biology
Frederic Brosseron, Kilian Kleemann, Carl-Christian Kolbe, Francesco Santarelli, Sergio Castro-Gomez, Pawel Tacik, Eicke Latz, Frank Jessen, Michael T. Heneka
Summary: Studies have shown a close correlation between a set of inflammatory markers and levels of tau or neurofilament, suggesting an inflammatory response to neuronal damage. These markers could be important in diagnosing AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tarcio Teodoro Braga, Laureane Nunes Masi, Catia Lira do Amaral, Vinicius Nunes Cordeiro Leal, Dhemerson Souza de Lima, Thiago Andrade Patente, Jose Alexandre Barbuto, Maria L. Correa-Giannella, Mario Lauterbach, Carl Christian Kolbe, Eicke Latz, Niels Olsen Saraiva Camara, Alessandra Pontillo, Rui Curi
Summary: The study found that macrophages in Type 1 diabetes patients are in an inflammatory state, and docosahexaenoic acid (DHA) can alleviate this inflammation.
Review
Biochemistry & Molecular Biology
Nathaniel L. Hepowit, Carl-Christian Kolbe, Sarah R. Zelle, Eicke Latz, Jason A. MacGurn
Summary: The regulatory influence of ubiquitin in cellular processes is vast, with phosphorylation playing a key role in enhancing the complexity of the ubiquitin code. Phosphorylation can affect the function of ubiquitin at different sites and its crosstalk with other modifiers.
Article
Immunology
Benjamin Kraemer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-Garcia, Jonas Schulte-Schrepping, Kim Melanie Kaiser, Gereon J. Rieke, Jenny Bischoff, Malte B. Monin, Christoph Hoffmeister, Stefan Schlabe, Elena De Domenico, Nico Reusch, Kristian Haendler, Gary Reynolds, Nils Bluethgen, Gudrun Hack, Claudia Finnemann, Hans D. Nischalke, Christian P. Strassburg, Emily Stephenson, Yapeng Su, Louis Gardner, Dan Yuan, Daniel Chen, Jason Goldman, Philipp Rosenstiel, Susanne Schmidt, Eicke Latz, Kevin Hrusovsky, Andrew J. Ball, Joe M. Johnson, Paul-Albert Koenig, Florian Schmidt, Muzlifah Haniffa, James R. Heath, Beate M. Kuemmerer, Verena Keitel, Bjoern Jensen, Paula Stubbemann, Florian Kurth, Leif E. Sander, Birgit Sawitzki, Anna C. Aschenbrenner, Joachim L. Schultze, Jacob Nattermann
Summary: The study revealed differences in IFN-α and TNF responses between severe and moderate COVID-19 cases, with NK cells playing a role in anti-SARS-CoV-2 activity but being functionally impaired in severe patients, and NK cell dysfunction potentially impacting disease outcome in severe COVID-19 patients.
Article
Immunology
Zsofia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellan, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Duewell, Marta Lovotti, Karlotta Bosch, Sabine Dickhoefer, Ana Marcu, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Loeffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kuemmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N. R. Weber
Summary: The study reveals that Bruton's tyrosine kinase (BTK) affects multiple levels of NLRP3 regulation by interacting with NLRP3 and phosphorylating conserved tyrosine residues upon inflammasome activation, promoting NLRP3 relocalization, oligomerization, ASC polymerization, and inflammasome assembly. This suggests BTK as a multifunctional positive regulator of NLRP3 regulation and its phosphorylation of NLRP3 as a potential therapeutic target for controlling inflammation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Hannah Scheiblich, Luc Bousset, Stephanie Schwartz, Angelika Griep, Eicke Latz, Ronald Melki, Michael T. Heneka
Summary: Research has shown that microglia react differently to various forms of α-syn, with NLRP3 inflammasome playing a crucial role in this process, and NLRP3 inhibition can improve the clearance efficiency of α-syn oligomers.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Neurosciences
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Pablo Garcia Gonzalez, Roisin M. McManus, Christina Ising, Francesco Santarelli, Carl-Christian Kolbe, Lisa M. Haesler, Steffen Wolfsgruber, Marta Marquie, Merce Boada, Adelina Orellana, Itziar de Rojas, Sandra Roeske, Oliver Peters, Nicoleta-Carmen Cosma, Arda Cetindag, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjorn H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. Munk, Emrah Duzel, Renat Yakupov, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Charlotte E. Teunissen, Natalie L. Marchant, Annika Spottke, Mathias Jucker, Eicke Latz, Michael Wagner, David Mengel, Matthis Synofzik, Frank Jessen, Alfredo Ramirez, Agustin Ruiz, Michael T. Heneka
Summary: Understanding neuroinflammation in Alzheimer's disease is crucial, as evident from the analysis of inflammatory biomarkers in pre-dementia individuals showing close interactions between inflammation and accumulating neurodegeneration. Additionally, higher levels of specific biomarkers are associated with larger brain structure and stable cognitive outcomes at follow-up.
Article
Multidisciplinary Sciences
Marco Orecchioni, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Zbigniew Mikulski, William B. Kiosses, Zhichao Fan, Lai Wen, Yunmin Jung, Payel Roy, Amal J. Ali, Yukiko Miyamoto, Matthew Mangan, Jeffrey Makings, Zhihao Wang, Angela Denn, Jenifer Vallejo, Michaela Owens, Christopher P. Durant, Simon Braumann, Navid Mader, Lin Li, Hiroaki Matsunami, Lars Eckmann, Eicke Latz, Zeneng Wang, Stanley L. Hazen, Klaus Ley
Summary: This study found that mouse vascular macrophages express the olfactory receptor Olfr2, which can detect and activate the inflammasome, leading to interleukin-1b secretion. It was also discovered that human and mouse blood plasma contains octanal, which can activate Olfr2 and its human ortholog OR6A2. Increasing octanal levels exacerbates atherosclerosis, while targeting Olfr2 gene significantly reduces atherosclerotic plaques. These findings suggest that inhibiting OR6A2 may be a promising strategy for preventing and treating atherosclerosis.
Article
Cell Biology
Rebecca Elena Mainz, Stefanie Albers, Madhuri Haque, Roland Sonntag, Nicole Simone Treichel, Thomas Clavel, Eicke Latz, Kai Markus Schneider, Christian Trautwein, Tobias Otto
Summary: This study evaluates a novel mouse model for alcoholic liver disease (ALD) and investigates the role of NLRP6 inflammasome in intestinal homeostasis and ALD progression. The study shows that alcohol consumption triggers liver injury and changes in intestinal microbial communities. Inhibiting NLRP6 signaling has a minor effect on intestinal homeostasis but reduces hepatic immune cell infiltration. These findings suggest a disease-aggravating role of NLRP6 in ALD.
Article
Medicine, Research & Experimental
Damien Bertheloot, Carlos W. S. Wanderley, Ayda H. Schneider, Lisa D. J. Schiffelers, Jennifer D. Wuerth, Jan M. P. Toedtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S. Ribeiro, Lea-Marie Jenster, Nathalia Rosero, Yonas M. Tesfamariam, Fernando Q. Cunha, Florian Schmidt, Bernardo S. Franklin
Summary: Inflammasomes are activated by intracellular clues and play important roles in cell death and inflammation. This study demonstrates that a specific antibody can neutralize activated inflammasomes and alleviate inflammatory diseases.
EMBO MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Laura Migliari Branco, Marcelo Pires Amaral, Henning Boekhoff, Ana Beatriz Figueiredo de Lima, Ingrid Sancho Farias, Silvia Lucena Lage, Gustavo Jose Silva Pereira, Bernardo Simoes Franklin, Karina Ramalho Bortoluci
Summary: Recent studies have shown that the NAIP/NLRC4 inflammasome can be activated not only in bacterial infections but also in non-bacterial infections and sterile inflammation. The involvement of cathepsins, known for their role in NLRP3 activation, in the regulation of NAIP/NLRC4-mediated responses to cytosolic flagellin has also been discovered. This study provides new insights into the role of cathepsins in the NAIP/NLRC4 inflammasome activation.
CELL DEATH & DISEASE
(2022)
Article
Respiratory System
Konrad Peukert, Folkert Steinhagen, Mario Fox, Caroline Feuerborn, Susanne Schulz, Benjamin Seeliger, Patrick Schuss, Matthias Schneider, Stilla Frede, Andrea Sauer, Christian Putensen, Eicke Latz, Christoph Wilhelm, Christian Bode
Summary: The study found that tetracycline can reduce silica-induced lung injury and fibrosis associated with chronic silicosis by inhibiting caspase-1 activation and the production of IL-1 beta. Tetracycline may be an effective treatment for patients with silicosis and other diseases involving silicotic inflammation.
RESPIRATORY RESEARCH
(2022)
Review
Medicine, General & Internal
Marcus J. Moeller, Rafael Kramann, Twan Lammers, Bernd Hoppe, Eicke Latz, Isis Ludwig-Portugall, Peter Boor, Juergen Floege, Christian Kurts, Ralf Weiskirchen, Tammo Ostendorf
Summary: Organ fibrogenesis, characterized by a common pathophysiological final pathway, independent of the progressive disease, offers potential therapeutic targets. The SFB/TRR57 consortium successfully identified new mechanisms and established novel therapeutic approaches to interfere with hepatic and renal fibrosis. This review focuses on the consortium's key findings related to renal fibrosis, addressing new relevant mechanisms, immunological contributors, and modulation strategies.
FRONTIERS IN MEDICINE
(2022)